A woman walks into a clinic, she’s eight months pregnant: tired, pale, anemic. Her last pregnancy ended early—an emergency C-section at 32 weeks. This time, her obstetrician happens to flip through an old chart and finds a diagnosis so rare, most doctors will never encounter it. In this episode, follow a multidisciplinary team’s race to design a complex care plan that, despite many challenges, keeps mother and baby safe.

A young man walks into a hemophilia treatment center. He’s limping, certain his ankle is bleeding again—same as always. But this time, the team discovers the pain may be coming from something else, something that isn’t in the patient’s chart. In this story, we explore the many ways and forms pain can present, and the importance of treating the whole person.

Transitioning hemophilia care from pediatric to adult care sounds simple enough. At home, though, it can be complicated—habits run deep, and for parents of children with hemophilia, the line between protection and independence isn’t always clear. In this episode, we’ll explore how hemophilia treatment centers put transition care into practice to help teens and young adults with bleeding disorders navigate taking ownership of their treatment and their first steps toward independence.

A young boy goes to urgent care, he’s fallen and his knee is swollen – likely a soft tissue trauma or at worst a minor joint bleed. He’s given a brace, told to rest. At follow up, everything is as expected – until a nurse reviews his chart and sees the child has hemophilia. We’re no longer talking about a minor joint bleed, we’re talking about a joint bleed, that, if left untreated, could lead to permanent damage. 

A young man calls his doctor – he has hemophilia and joint pain – he knows what this is, he’s had it before: it’s a knee bleed. He’s given himself three doses of blood clotting factor, but it’s not working. When he arrives at the hemophilia treatment center, his care team takes a closer look – and what they find will change everything. 

If you work in healthcare, you’ve felt it—that moment when communication breaks down. In this season of DDx, we’re going inside hemophilia treatment centers to hear real stories of how collaboration works, what it looks like in real time, and how filling gaps in communication helps ensure patients get the care they deserve.

A patient with flu-like symptoms turns out to have lung cancer—prompting a deeper look at missed screenings, disparities, and evolving treatment strategies.

While we’re hard at work on the next season, we wanted to bring you something timely—and thought-provoking. It’s a case that might just change the way you think about lung cancer treatment and diagnosis. Listen to the trailer, then stay tuned for the full bonus episode—coming soon to your feed.

Last time, we spoke with the co-creator of DAX Copilot, Dr. Jared Pelo, about what DAX can actually do and the questions it raises about AI and the future of medicine. But today, we’re not just continuing that conversation—we have news. Dr. Pelo is back to share a major development, and talk about what this news means for physicians, patients and the future of clinical practice. Not only does Dr. Pelo break this exciting news with us, but he answers some important questions and offers thoughtful examples to help us understand just how the latest breakthroughs will impact the way clinicians everywhere go about providing their care.

In this episode, we sit down with Dr. Jared Pelo, the co-creator of DAX Copilot, to delve into the origins and future of the AI-powered clinical documentation solution. Discover how DAX Copilot aims to revolutionize medical workflows, the challenges it faces, and the potential it holds for transforming patient care. Tune in to hear insights from the creator himself on the evolving role of AI in healthcare and what lies ahead.

As the owner of a small clinic and a member of his local hospital’s executive committee, Dr. Robert McDermott has a unique perspective into the challenges and rewards of integrating new technology on a variety of scales. Join us as he shares his experiences implementing and using DAX Copilot as a documentation assistant. Dr. McDermott first saw what the AI-powered solution did for his own practice, and later advocated for its use on a larger scale. Join us as he discusses his approach.

Dr. Alfred Atanda joins us to discuss the stress and anxieties of managing a busy clinic and the inefficiencies in healthcare workflows. He highlights how DAX Copilot, an AI-powered solution, helps by recording patient visits and drafting medical notes, improving efficiency throughout his clinic as well as patient care.

Dr. Theresa Nguyen highlights the impact of burnout on both doctors and patients, emphasizing that nearly half of physicians report feeling its effects. She explains how DAX Copilot, an AI documentation and clinical workflow assistant, has significantly reduced her stress by automatically creating structured notes from doctor-patient conversations. This technology allows her to spend more quality time with patients and reduces the time spent on documentation after work.

We sit down with Dr. Patrick McGill, who shares his experiences and challenges as Chief Transformation Officer at Community Health Network and as a family doctor at South Indy Family Practice in Indianapolis, Indiana. Dr. McGill discusses the growing disconnect between doctors and patients due to administrative tasks and required documentation, which often take away valuable time and focus from patient care. Dr. McGill discusses his initial skepticism about integrating AI-powered solutions and his eventual relief, both personally and professionally, upon using the cutting-edge technology to help restore human connections in his practice. 

Imagine a world where doctors spend more time with patients—and less on paperwork. This season on DDx, we explore DAX Copilot, an AI assistant that listens to doctor-patient conversations and drafts notes for medical records. We’re asking doctors what it’s really like to use this technology. Does it help? Does it get in the way? And what does it mean for the doctor-patient relationship when AI is in the room too? Real stories from the frontlines of healthcare. Season 11 of DDx is coming soon.

After a lifetime of treating her rare bone disease, X-linked hypophosphatemia, a patient is at the end of her rope. She’s in pain, frustrated, and nothing seems to help. So when a clinical trial presents itself, her doctor isn’t sure she’ll want to participate. While the decision to participate is surprising, the results of the clinical trial are astonishing.

A 45-year-old is out for a drive. As she accelerates her stick-shift car, she starts to experience familiar, and scary, symptoms: facial tingling, numbness around her mouth, and her hands cramp and lock onto the steering wheel … Her story takes many wrong turns, but eventually she is diagnosed with hypoparathyroidism, a rare bone disease, and finds an experimental treatment that changes her life.

A 9-year-old cannonballs into the shallow end of the pool. There’s a stab of pain through her hip. What seems like just a bump takes a complicated turn. After discovering a bone growth, the child is diagnosed with fibrodysplasia ossificans progressiva. This extremely rare bone disorder has a devastating impact, but thanks to unexpected areas of research, patients have new reasons to hope.

During a 20-week ultrasound appointment, there’s devastating news: the baby’s bones are broken and bowed. Despite this, the baby is born and does well. After testing, all signs point to hypophosphatasia. And thanks to the life-changing treatment of enzyme replacement therapy, today, this child and many others with this rare bone disease are living happy, healthy lives.

What’s thought to be a case of newborn hiccups unravels to a grim diagnosis: generalized arterial calcification of infancy, or GACI, a rare genetic condition with a challenging prognosis. Nearly half of infants don't survive beyond six months. But a revolutionary clinical trial could potentially transform this child's life and the lives of others with this disease.