Could histamine and antihistamines do more than just affect our allergies? Actually yes. Today we discuss new and recent research in the world of histamine, and believe us, there's some really cool stuff.

Most of us know the feeling. But what are we actually experiencing when we experience allergies? How does being around plants and pollen make us all sniffly? Why does this beautiful season have such a dark side? Let's find out.

Melissa and Jam dive deep into the topic of FDA regulations, particularly focusing on food additives like red food dye. They discuss the complexities of the FDA's approval process, the Delaney Clause, and recent changes in the regulation of red dye number 3, which has been banned in response to cancer risks found in rats. They also delve into how other countries like the UK and Canada are ahead of the U.S. in reevaluating approved substances. The episode includes personal anecdotes and a discussion on the role of public awareness in influencing FDA policies. They wrap up with a lighthearted conversation about sprinkles and favorite dyed foods.

Melissa and Jam delve into a variety of interesting chemistry-related questions sourced from Reddit. They explore why farts stop smelling over time, the non-oily nature of Castile soap, why cookies and candies remain safe to eat at room temperature, and the mechanics behind rice cookers. They also discuss how opening a bottle can freeze its contents and offer reassurance to a chemistry Ph.D. student worried about forgetting basic chemistry knowledge. The episode is filled with insightful explanations, humor, and chemistry support, answering the everyday scientific queries of curious Reddit users.

Melissa and Jam explore why gasoline doesn't freeze in extremely low temperatures while water and other substances do. They delve into the concepts of intermolecular forces, polarity, and how impurities can affect the freezing and melting points of substances. The discussion includes a comparison of the behavior of different substances at varying temperatures, and a light-hearted conversation on favorite liquids that can exist in both liquid and solid states. They also hint at upcoming merchandise related to the topic.

Why is honey sticky but salt isn’t? What’s the difference between things that stick and things that just feel sticky? In this episode, Melissa and Jam dive into the chemistry behind adhesion, cohesion, and the forces that make substances cling to surfaces (and to our fingers). They explore intermolecular forces, viscosity, and why some things are nearly impossible to separate once they’re bonded. Plus, Jam shares a hilarious mix-up of words, and Melissa breaks down why this topic turned out to be trickier than expected!

Melissa and Jam address a listener's question about the FDA's reliability in approving products. They discuss the intersection of chemistry, government, and society, focusing on FDA's role in regulating food and drugs. The episode includes a deep dive into the historical thalidomide tragedy, the improvements in the FDA's approval process since then, and the nuances of trusting FDA-approved products. Through personal insights, they emphasize the complexities and challenges faced by the FDA in ensuring public safety.

Melissa and Jam delve into intriguing chemistry questions posed by their listeners. They explore whether all salts are salty, the chemistry of gunshot residue and fingerprinting, and the reactions between chemicals and sound waves. Special guest Maison, Melissa's husband, joins to discuss sourdough starter cultures and answer sourdough-related queries. The episode concludes with insightful comments from their Chemmunity members and reassurances about their well-being amid late-night recordings.

Jam and Melissa discuss the complexities and consequences of recent executive orders surrounding science funding. Melissa provides insight into how these changes impact university research, faculty positions, and broader society. The duo also highlights the historical context and importance of DEI in academia, emphasizing the broader implications of funding uncertainties on current and future science initiatives.

This week, Melissa and Jam explore the chemistry of rust. What even is it? Where does it come from? Is it bad? Is it reversible? Let's get into it.

Tums, alka seltzer, and other antacids: they're simple, they've been around for a long time, but they're a tried and true method for helping our stomachs. But how do they work? What's the chemistry behind these unsung heroes?

In this episode Melissa and Jam delve into the fascinating biochemistry behind sourdough bread. They explore the role of microorganisms, including different strains of yeast and bacteria, in the fermentation process. The discussion covers how these organisms contribute to the unique flavors and textures of sourdough, and addresses common questions from listeners about its health benefits, the impact of tap water, and the variability of sourdough starters. The episode combines scientific insights with personal anecdotes about sourdough baking, shedding light on why this bread is so special and why it has gained popularity.

Melissa and Jam delve into why some people hiccup when eating carrots, the fascinating uses of poinsettias in food packaging, the role of benzene as a carcinogen, and the controversies surrounding hydrogen-rich water bottles. Additionally, they explain how catalysts work and respond to various chemistry-related inquiries from their engaged audience.

In this episode, Jam recounts a humorous yet enlightening story of accidentally taking a dog-sized dose of Benadryl and the sleepy consequences that followed. Melissa, a chemist, dives deep into the chemistry of antihistamines, explaining the difference between first-generation (drowsy) and second-generation (non-drowsy) antihistamines. The episode covers the role of histamine in the body's allergic reactions and how different antihistamines interact with histamine receptors. Melissa elucidates the chemical structures of these medicines and how their polarity affects their ability to cross the blood-brain barrier, ultimately influencing whether they cause drowsiness.

In this episode Melissa and Jam embark on an 'Ask a Chemist' segment, delving into the ethics surrounding the field of chemistry and addressing listener questions. They discuss managing discussions on the dark side of chemistry, why certain chemicals emit characteristic colors in the flame test, and share personal experiences regarding the toughest classes in their educational journeys. The episode also features listener interactions about nostalgic glow-in-the-dark items and anecdotes about the complexities and joys of studying and practicing chemistry. Join them for an engaging exploration of the ethical dimensions of chemistry and the field's fascinating nuances.

Melissa and Jam dive into a fun and educational holiday-themed activity using poinsettia plants. They explore the chemistry behind these festive plants, specifically focusing on anthocyanins, which are pigments that give the leaves their red color and act as pH indicators. The episode includes a hands-on experiment that listeners can try at home to visualize how different household items can change the color of poinsettia leaves. Perfect for a holiday break activity that educates and entertains both kids and adults.

Happy holidays, we hope you have a wonderful season whatever you celebrate! We've got a holiday related episode for you: LEDs. Well I guess we use them all year round, but they get an extra spotlight this time of year. What are they? How do they work? How are they different from other lights? Let's find out!

Melissa and Jam dive into the chemistry behind air dusters. They explore the components inside these cans, and how the physical properties of these chemicals can lead to rapid evaporation, cold burns, and potential hazards. Listeners will learn about the processes of pressure and boiling, the potential dangers of misuse, and how these air dusters work to clean keyboards and other surfaces. The episode is inspired by listener questions and personal anecdotes, making the complex chemistry accessible and engaging.

Here's another bonus episode dedicated to teaching a specific chemistry experiment you can do at home. This month, we see what happens when we combine chocolate and gum. Yep, you read that right. And yes, it's a little gross.

In this episode Melissa and Jam delve into the fascinating world of chewing gum. They start by discussing awkward combinations of food and gum, leading to an exploration of what gum is made of. The conversation covers the basics of gum composition, including the roles of sugar, flavor, and especially the gum base, which itself is made of polymers.