Welcome to Cardiology Today – Recorded November 03, 2025. This episode summarizes 5 key cardiology studies on topics like electrophysiology and non-obstructive hypertrophic cardiomyopathy. Key takeaway: Young Adult Lipoproteins Predict Future A.S.C.V.D.. Article Links: Article 1: Dietary carbohydrate quality, fibre-rich food intake, and left ventricular structure and function: the CARDIA study. (European heart journal) Article 2: Cumulative exposure to atherogenic lipoprotein particles in young adults and subsequent incident atherosclerotic cardiovascular disease. (European heart journal) Article 3: Rationale, Design, and Baseline Characteristics of the Polypill for Heart Failure with Reduced Ejection Fraction (POLY-HF) Trial. (Journal of cardiac failure) Article 4: Accelerated Bachmann bundle area pacing for atrial resynchronization in patients with non-obstructive hypertrophic cardiomyopathy and heart failure with preserved ejection fraction: A randomized crossover trial. (Heart rhythm) Article 5: Small patients, significant findings: Electrophysiological properties of Bachmann’s bundle in pediatric patients. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/young-adult-lipoproteins-predict-future-a-s-c-v-d-11-03-25/ Featured Articles Article 1: Dietary carbohydrate quality, fibre-rich food intake, and left ventricular structure and function: the CARDIA study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40626880 Summary: This study from the Coronary Artery Risk Development in Young Adults (C.A.R.D.I.A.) cohort investigated the association between dietary carbohydrate quality and fibre-rich food intake with left ventricular structure and function. The research aimed to clarify how specific macronutrient and food group intakes relate to cardiac phenotypes, a critical step in understanding progression to heart failure. Identifying these lifestyle risk factors is essential for developing strategies to prevent or slow cardiac dysfunction. Article 2: Cumulative exposure to atherogenic lipoprotein particles in young adults and subsequent incident atherosclerotic cardiovascular disease. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40613415 Summary: This research quantified the relationship between cumulative and usual yearly exposure to atherogenic lipoprotein particles in young adults and subsequent incident atherosclerotic cardiovascular disease. Utilizing follow-up data of young adults aged 18 to less than 40 years from the Coronary Artery Risk Development in Young Adults (C.A.R.D.I.A.) study, this investigation focused on apolipoprotein B, low-density lipoprotein particles, and triglyceride-rich lipoprotein particles. The study established that such exposure during early adulthood significantly increases future atherosclerotic cardiovascular disease risk, providing critical data for understanding early life risk factors and informing preventative strategies. Article 3: Rationale, Design, and Baseline Characteristics of the Polypill for Heart Failure with Reduced Ejection Fraction (POLY-HF) Trial. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41177219 Summary: The P.O.L.Y.-H.F. trial was designed to evaluate a polypill strategy for patients with heart failure with reduced ejection fraction, addressing suboptimal real-world utilization of guideline-directed medical therapy. This open-label randomized controlled trial, conducted across two centers, enrolled adults with a left ventricular ejection fraction of 40 percent or less who were not receiving targeted guideline-directed medical therapy. The study’s rationale, design, and baseline characteristics provide a foundational framework for investigating whether a simplified polypill regimen can improve therapeutic adherence and patient outcomes in this population. Article 4: Accelerated Bachmann bundle area pacing for atrial resynchronization in