Welcome to Cardiology Today – Recorded November 05, 2025. This episode summarizes 5 key cardiology studies on topics like computed tomography emphysema and population structure. Key takeaway: Aortic Stenosis: Leaflet-Specific Pathology Revealed. Article Links: Article 1: Impact of standardized team-based care on cardiogenic shock outcomes over time. (ESC heart failure) Article 2: SPIROMICS HF: Rationale, Design, and Reproducibility of Measures. (Circulation. Heart failure) Article 3: Clinical and Cardiovascular Magnetic Resonance Characteristics of Veteran Male Endurance Athletes With Atrial Fibrillation: VENTOUX-AF. (Journal of the American Heart Association) Article 4: Dual Contrast-Enhanced Microcomputed Tomography Uncovers Leaflet-Dependent Patterns of Macrocalcification, Fibrous Extracellular Matrix Remodeling, and Adipocyte Degeneration in Calcific Aortic Stenosis. (Journal of the American Heart Association) Article 5: Admixture Mapping of Lipid Traits in Hispanic Americans. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/aortic-stenosis-leaflet-specific-pathology-revealed-11-05-25/ Featured Articles Article 1: Impact of standardized team-based care on cardiogenic shock outcomes over time. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41189091 Summary: This study investigated the impact of implementing standardized team-based protocols on cardiogenic shock outcomes over time. Researchers analyzed 1453 consecutive patients from a single-center cardiogenic shock registry, comparing outcomes between two periods: 2017-2019 and 2020-2022. This methodology aimed to determine the influence of multidisciplinary management strategies on patient outcomes. The research establishes a crucial framework for evaluating the effectiveness of structured care approaches in this critical condition. Article 2: SPIROMICS HF: Rationale, Design, and Reproducibility of Measures. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41190426 Summary: HeF.pEF: Rationale, Design, and Reproducibility of Measures. The S.P.I.R.O.M.I.C.S. HeF.pEF study outlines its rationale and design for investigating the complex interplay between chronic obstructive pulmonary disease and Heart Failure with Preserved Ejection Fraction. This research specifically tests hypotheses linking new computed tomography emphysema subtypes with distinct cardiovascular phenotypes, including cor pulmonale and cor pulmonale parvus. The study also focuses on common airway branch variations and the reproducibility of its measures, establishing a robust framework for future discoveries. This work is crucial for identifying shared underlying mechanisms and improving management strategies for patients with these often coexisting conditions. Article 3: Clinical and Cardiovascular Magnetic Resonance Characteristics of Veteran Male Endurance Athletes With Atrial Fibrillation: VENTOUX-AF. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41182011 Summary: The V.E.N.T.O.U.X.-A.F. cross-sectional study investigated factors associated with atrial fibrillation in 39 veteran male endurance athletes, a population known for increased A.fib risk. Researchers aimed to determine if left atrial remodeling, assessed by cardiovascular magnetic resonance, exercise blood pressure, and bradyarrhythmia detected by implantable loop recorders, were linked to atrial fibrillation. This research provides a crucial methodological approach to unravel the unclear pathogenesis of atrial fibrillation in this unique athletic cohort. The findings will help inform targeted screening and preventive strategies for these individuals. Article 4: Dual Contrast-Enhanced Microcomputed Tomography Uncovers Leaflet-Dependent Patterns of Macrocalcification, Fibrous Extracellular Matrix Remodeling, and Adipocyte Degeneration in Calcific Aortic Stenosis. Journal: Journal of the

Welcome to Cardiology Today – Recorded November 05, 2025. This episode summarizes 5 key cardiology studies on topics like gender-affirming hormone therapy and United States. Key takeaway: Aortic Dilation Growth Patterns Reshape Surveillance. Article Links: Article 1: Transgender persons receiving gender-affirming hormone therapy: risk of acute cardiovascular events in a Dutch cohort study. (European heart journal) Article 2: Finerenone in patients with severe heart failure: The FINEARTS-HF trial. (European journal of heart failure) Article 3: Short- and mid-term effects of empagliflozin on sodium balance and fluid regulation in chronic heart failure. (European journal of heart failure) Article 4: Sex Disparities in Ischemic Heart Disease Mortality Across United States: The Southern Burden of Excess Body Weight and Diet. (Journal of the American Heart Association) Article 5: Growth Trajectories in Ascending Thoracic Aortic Dilation: Classification and Implications for the Effectiveness of Real-World Imaging Surveillance. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/aortic-dilation-growth-patterns-reshape-surveillance-11-05-25/ Featured Articles Article 1: Transgender persons receiving gender-affirming hormone therapy: risk of acute cardiovascular events in a Dutch cohort study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41187090 Summary: This study investigated the association between gender-affirming hormone therapy and cardiovascular event risk in transgender individuals compared to the general population. A key methodological advancement was the adjustment for socioeconomic status and lifestyle factors, which were not accounted for in previous research. This Dutch cohort study aims to provide a more accurate assessment of cardiovascular risk in this specific population. The research is critical for refining cardiovascular care guidelines and enhancing risk stratification for transgender persons receiving gender-affirming hormone therapy. Article 2: Finerenone in patients with severe heart failure: The FINEARTS-HF trial. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41186217 Summary: This study aimed to assess the prevalence of severe heart failure, its associated cardiovascular outcome risk, and the treatment response to finerenone, a non-steroidal mineralocorticoid receptor antagonist. The F.I.N.E.A.R.T.S.-H.F. trial specifically focused on patients with severe heart failure across the full spectrum of left ventricular ejection fraction. The research seeks to clarify the role and efficacy of finerenone in a broad heart failure population. This investigation could broaden therapeutic options for severe heart failure, irrespective of left ventricular ejection fraction. Article 3: Short- and mid-term effects of empagliflozin on sodium balance and fluid regulation in chronic heart failure. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41186108 Summary: This randomized, placebo-controlled trial investigated the effects of empagliflozin on fluid and sodium balance over a three-month period in patients with chronic heart failure. Seventy-four patients with New York Heart Association class I.I. to I.I.I. chronic heart failure and an ejection fraction of 49 percent or less were enrolled. The study aimed to determine the persistence of empagliflozin’s beneficial effects beyond the acute phase, where urinary glucose and sodium excretion are well-established. This research is crucial for optimizing long-term management strategies for chronic heart failure. Article 4: Sex Disparities in Ischemic Heart Disease Mortality Across United States: The Southern Burden of Excess Body Weight and Diet. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41182171 Summary: This study analyzed sex disparities in ischemic hear

Welcome to Cardiology Today – Recorded November 04, 2025. This episode summarizes 5 key cardiology studies on topics like s.P.A.P. and evolocumab. Key takeaway: Prognostic Markers for Recovered E.F. Heart Failure. Article Links: Article 1: Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial. (Circulation) Article 2: Prognostic Value of Exercise Right Ventricular-Pulmonary Arterial Coupling in Primary Mitral Regurgitation. (Circulation) Article 3: Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke. (Circulation) Article 4: Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients with Chronic Kidney Disease. (Circulation) Article 5: Prognostic Value of Natriuretic Peptide Levels in Heart Failure With Recovered Ejection Fraction. (Circulation. Heart failure) Full episode page: https://podcast.explainheart.com/podcast/prognostic-markers-for-recovered-e-f-heart-failure-11-04-25/ Featured Articles Article 1: Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41183181 Summary: The S.T.O.R.M.-P.E. trial conducted the first reported randomized controlled trial to evaluate the efficacy and safety of mechanical thrombectomy, specifically computer assisted vacuum thrombectomy, combined with anticoagulation versus anticoagulation alone for acute intermediate-high risk pulmonary embolism. This trial focused on patients with an elevated right ventricular to left ventricular diameter ratio, who are at increased risk of early clinical decompensation and mortality. By rigorously comparing these treatment strategies, the study established foundational data on whether mechanical thrombectomy can effectively relieve acute right ventricular pressure overload and normalize hemodynamics to improve patient outcomes. Article 2: Prognostic Value of Exercise Right Ventricular-Pulmonary Arterial Coupling in Primary Mitral Regurgitation. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178584 Summary: This international multicenter cohort study aimed to evaluate the prognostic value of right ventricular-pulmonary arterial coupling in patients with primary mitral regurgitation. The study specifically assessed this coupling by measuring the ratio of tricuspid annular plane systolic excursion to systolic pulmonary artery pressure, both at rest and during exercise. By undertaking this comprehensive evaluation, the research established whether these non-invasive metrics provide a critical tool for risk stratification and improved management of patients with clinically significant primary mitral regurgitation. Article 3: Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178569 Summary: This study investigated the efficacy and safety of achieving very low levels of low-density lipoproteins-cholesterol in patients with a history of ischemic stroke. Analyzing data from the F.O.U.R.I.E.R. trial, which studied evolocumab in stable atherosclerotic cardiovascular disease, researchers determined the impact of intensive L.D.L.-C reduction on recurrent stroke and other major adverse cardiovascular events. The findings provide crucial clarity on optimizing lipid management strategies for this high-risk patient population, aiming to improve secondary prevention outcomes following ischemic stroke. Article 4: Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients with Chronic Kidney Disease. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178538 Summary: This cross-sec

Welcome to Cardiology Today – Recorded November 03, 2025. This episode summarizes 5 key cardiology studies on topics like fetal tachycardia and digoxin. Key takeaway: Self-Powered Pacemakers: Heart’s Own Energy. Article Links: Article 1: Narrowed sinus rhythm electrograms in the zone of uniform slow conduction are helpful to identify VT isthmus location, shape, and orientation. (Heart rhythm) Article 2: Bioelectric energy harvesting from myocardial tissue in vivo: A new method for biological energy collection. (Heart rhythm) Article 3: Prolonged hospitalization after catheter ablation of ventricular tachycardia: Predictors and outcomes. (Heart rhythm) Article 4: Effect of leadless left ventricular endocardial and left bundle branch area pacing on biventricular repolarization metrics. (Heart rhythm) Article 5: The maternal exposure of digoxin and flecainide in relation to the safety and effectiveness in the treatment of non-hydropic fetal tachycardia. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/self-powered-pacemakers-hearts-own-energy-11-03-25/ Featured Articles Article 1: Narrowed sinus rhythm electrograms in the zone of uniform slow conduction are helpful to identify VT isthmus location, shape, and orientation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40578654 Summary: isthmus location, shape, and orientation. This study aimed to improve the identification of ventricular tachycardia (V.T.) isthmus characteristics using substrate mapping. Researchers conducted 31 canine postinfarction experiments, creating an infarct and border zone in the anterior left ventricle. The findings suggest that narrowed sinus rhythm electrograms in the zone of uniform slow conduction are valuable markers for precisely identifying the location, shape, and orientation of the V.T. isthmus. This advancement provides a more accurate method for delineating V.T. reentry circuits, which is critical for successful catheter ablation. Article 2: Bioelectric energy harvesting from myocardial tissue in vivo: A new method for biological energy collection. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40499804 Summary: This study explored the innovative concept of bioelectric energy harvesting directly from myocardial tissue in vivo. Researchers developed an electrophysiological measurement system utilizing microneedle electrodes to collect energy from the heart. The investigation compared the available harvested energy with the energy consumption required for cardiac pacing. This research demonstrates the potential feasibility of an internal, self-powered energy source for cardiac devices, representing a significant step towards eliminating the need for traditional batteries in pacemakers. Article 3: Prolonged hospitalization after catheter ablation of ventricular tachycardia: Predictors and outcomes. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40472946 Summary: This retrospective cohort study investigated predictors of prolonged hospitalization following catheter ablation of ventricular tachycardia (V.T.) in patients with structural heart disease. Researchers analyzed 318 patient cases between January 2022 and October 2024, defining prolonged hospitalization as a post-ablation length of stay greater than seven days. The study successfully identified key factors predicting extended hospitalization after V.T. ablation, along with their subsequent impact on patient outcomes. These findings are critical for improving patient selection, optimizing post-procedural care strategies, and potentially reducing adverse events. Article 4: Effect of leadless left ventricular endocardial and left bundle branch area pacing on biventricular repolarization metrics. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40436356 Summary: This study aimed to evaluate the impact of leadless left ventricular (L.V.) endocardial pacing and leadless left bundle bran

Welcome to Cardiology Today – Recorded November 03, 2025. This episode summarizes 5 key cardiology studies on topics like electrophysiology and non-obstructive hypertrophic cardiomyopathy. Key takeaway: Young Adult Lipoproteins Predict Future A.S.C.V.D.. Article Links: Article 1: Dietary carbohydrate quality, fibre-rich food intake, and left ventricular structure and function: the CARDIA study. (European heart journal) Article 2: Cumulative exposure to atherogenic lipoprotein particles in young adults and subsequent incident atherosclerotic cardiovascular disease. (European heart journal) Article 3: Rationale, Design, and Baseline Characteristics of the Polypill for Heart Failure with Reduced Ejection Fraction (POLY-HF) Trial. (Journal of cardiac failure) Article 4: Accelerated Bachmann bundle area pacing for atrial resynchronization in patients with non-obstructive hypertrophic cardiomyopathy and heart failure with preserved ejection fraction: A randomized crossover trial. (Heart rhythm) Article 5: Small patients, significant findings: Electrophysiological properties of Bachmann’s bundle in pediatric patients. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/young-adult-lipoproteins-predict-future-a-s-c-v-d-11-03-25/ Featured Articles Article 1: Dietary carbohydrate quality, fibre-rich food intake, and left ventricular structure and function: the CARDIA study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40626880 Summary: This study from the Coronary Artery Risk Development in Young Adults (C.A.R.D.I.A.) cohort investigated the association between dietary carbohydrate quality and fibre-rich food intake with left ventricular structure and function. The research aimed to clarify how specific macronutrient and food group intakes relate to cardiac phenotypes, a critical step in understanding progression to heart failure. Identifying these lifestyle risk factors is essential for developing strategies to prevent or slow cardiac dysfunction. Article 2: Cumulative exposure to atherogenic lipoprotein particles in young adults and subsequent incident atherosclerotic cardiovascular disease. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40613415 Summary: This research quantified the relationship between cumulative and usual yearly exposure to atherogenic lipoprotein particles in young adults and subsequent incident atherosclerotic cardiovascular disease. Utilizing follow-up data of young adults aged 18 to less than 40 years from the Coronary Artery Risk Development in Young Adults (C.A.R.D.I.A.) study, this investigation focused on apolipoprotein B, low-density lipoprotein particles, and triglyceride-rich lipoprotein particles. The study established that such exposure during early adulthood significantly increases future atherosclerotic cardiovascular disease risk, providing critical data for understanding early life risk factors and informing preventative strategies. Article 3: Rationale, Design, and Baseline Characteristics of the Polypill for Heart Failure with Reduced Ejection Fraction (POLY-HF) Trial. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41177219 Summary: The P.O.L.Y.-H.F. trial was designed to evaluate a polypill strategy for patients with heart failure with reduced ejection fraction, addressing suboptimal real-world utilization of guideline-directed medical therapy. This open-label randomized controlled trial, conducted across two centers, enrolled adults with a left ventricular ejection fraction of 40 percent or less who were not receiving targeted guideline-directed medical therapy. The study’s rationale, design, and baseline characteristics provide a foundational framework for investigating whether a simplified polypill regimen can improve therapeutic adherence and patient outcomes in this population. Article 4: Accelerated Bachmann bundle area pacing for atrial resynchronization in

Welcome to Cardiology Today – Recorded November 02, 2025. This episode summarizes 5 key cardiology studies on topics like acute coronary syndrome and A.T.T.R.-C.M.. Key takeaway: Survival Odds Slash Heart Failure Trial Bias. Article Links: Article 1: Cannabis use among young adults with acute coronary syndrome: impact on initial presentation and long-term prognosis. (Heart (British Cardiac Society)) Article 2: Left ventricular transthyretin amyloid load and apical sparing in patients with newly confirmed transthyretin amyloid cardiomyopathy. (European journal of heart failure) Article 3: Survival Odds to Minimize Risk Heterogeneity Bias in Heart Failure Trials: Application to Dapagliflozin. (Circulation. Heart failure) Article 4: Impact of the Swedish Care Coordination Act on Heart Failure Readmissions and Length of Stay. (Circulation. Heart failure) Article 5: Timing and Mode of Death Following Treatment of Neonatal Symptomatic Tetralogy of Fallot. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/survival-odds-slash-heart-failure-trial-bias-11-02-25/ Featured Articles Article 1: Cannabis use among young adults with acute coronary syndrome: impact on initial presentation and long-term prognosis. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41176318 Summary: This retrospective cohort study assessed the association between cannabis use at admission for acute coronary syndrome, or A.C.S., and long-term prognosis in young adults under 45 years old. Patients admitted between 2010 and 2025 who reported current tobacco use were classified based on urinary testing for cannabis upon admission. The research aimed to clarify the cardiovascular impact of cannabis use, which is increasing among young adults, by examining its link to long-term outcomes following an A.C.S. event. This study established a methodology to investigate the clinical implications of cannabis exposure on cardiovascular health in a high-risk population. Article 2: Left ventricular transthyretin amyloid load and apical sparing in patients with newly confirmed transthyretin amyloid cardiomyopathy. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41168134 Summary: This study investigated the relationship between echocardiographic apical sparing, a hallmark imaging feature quantified by the R.E.L.A.P.S. pattern, and myocardial transthyretin amyloid load in patients with newly confirmed transthyretin amyloid cardiomyopathy, or A.T.T.R.-C.M. The research aimed to clarify the histopathological and clinical implications of apical sparing in A.T.T.R.-C.M., a condition characterized by transthyretin amyloid deposition, left ventricular hypertrophy, and diastolic dysfunction. By establishing these associations, the study contributes to a more precise understanding of this complex disease and its prognostic indicators. Article 3: Survival Odds to Minimize Risk Heterogeneity Bias in Heart Failure Trials: Application to Dapagliflozin. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41170566 Summary: This research established a novel methodological approach utilizing “survival odds” to minimize risk heterogeneity bias in heart failure clinical trials. The study addressed the issue where conventional Cox proportional hazards models can underestimate treatment effects due to a disproportionate reduction of event-free patients in control groups over time. By demonstrating the application of this survival odds methodology to dapagliflozin, the research offers a more robust framework for evaluating drug efficacy. This advance ultimately improves the accuracy of clinical trial outcomes for heart failure treatments. Article 4: Impact of the Swedish Care Coordination Act on Heart Failure Readmissions and Length of Stay. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41170562 Su

Welcome to Cardiology Today – Recorded November 02, 2025. This episode summarizes 5 key cardiology studies on topics like donation after circulatory death and temperature dynamics. Key takeaway: N.R.P. for D.C.D. Hearts: 200 Cases Validate Method. Article Links: Article 1: Plasma-supplemented red cell concentrates as alternatives to whole blood in porcine ex vivo heart perfusion. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Two hundred cases of cardiac donation after circulatory death utilizing normothermic regional perfusion: The 4-year Vanderbilt experience. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Impact of right ventricular reserve function during exercise on aortic valve opening in patients with left ventricular assist device. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Temperature dynamics of donor lungs from procurement to reperfusion: Static ice versus controlled hypothermic storage. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Risk assessment models and survival in pulmonary arterial hypertension: A SPAHR analysis. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/n-r-p-for-d-c-d-hearts-200-cases-validate-method-11-02-25/ Featured Articles Article 1: Plasma-supplemented red cell concentrates as alternatives to whole blood in porcine ex vivo heart perfusion. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40490145 Summary: This study investigated alternatives to autologous whole blood for ex vivo heart perfusion, a technique aiming to expand the organ donor pool but facing logistical hurdles. Researchers compared red cell concentrate and rejuvenated red cell concentrate based perfusates against whole blood during a four-hour porcine ex vivo heart perfusion model. The study successfully assessed the impact of various perfusates on blood quality and myocardial function, establishing that plasma-supplemented red cell concentrates offer viable alternatives to whole blood. This advancement enhances the functional and logistical feasibility of ex vivo organ perfusion, which could increase donor heart availability. Article 2: Two hundred cases of cardiac donation after circulatory death utilizing normothermic regional perfusion: The 4-year Vanderbilt experience. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40456427 Summary: This study presents a four-year, single high-volume center’s experience with 200 cases of cardiac donation after circulatory death heart recovery using normothermic regional perfusion. Researchers retrospectively reviewed adult patients receiving cardiac allografts recovered via thoracoabdominal normothermic regional perfusion at Vanderbilt from October 2020 to November 2024. The study successfully documented the program’s evolution, establishing the feasibility and scalability of normothermic regional perfusion in a large cohort. This comprehensive experience offers crucial insights for standardizing practice and increasing the donor heart pool by validating this method for cardiac transplantation. Article 3: Impact of right ventricular reserve function during exercise on aortic valve opening in patients with left ventricular assist device. Journal: The Journal of heart and lung transplantation : the offici

Welcome to Cardiology Today – Recorded November 01, 2025. This episode summarizes 5 key cardiology studies on topics like donation after brain death and exercise intolerance. Key takeaway: Machine Perfusion Boosts Heart Transplant Outcomes. Article Links: Article 1: Proteomic and metabolomic profiling nominates druggable targets and biomarkers for pulmonary arterial hypertension-associated myopathy and exercise intolerance in male monocrotaline rats. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: National utilization and outcomes of heart transplantation using ex situ machine perfusion. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Heart transplantation in Ukraine during wartime: A retrospective cohort study of standard vs marginal donor heart transplantation outcomes. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Trajectories of FEV1 after lung transplantation and patient outcomes. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Impact of donor specific antibodies on longitudinal lung function and baseline lung allograft dysfunction. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/machine-perfusion-boosts-heart-transplant-outcomes-11-01-25/ Featured Articles Article 1: Proteomic and metabolomic profiling nominates druggable targets and biomarkers for pulmonary arterial hypertension-associated myopathy and exercise intolerance in male monocrotaline rats. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40651676 Summary: This study aimed to uncover mechanisms underlying skeletal muscle dysfunction and exercise intolerance in pulmonary arterial hypertension by using proteomic and metabolomic profiling. Researchers evaluated exercise capacity, muscle histopathology, mitochondrial density, proteomics, and metabolomics/lipidomics in quadriceps muscles of monocrotaline rats, a model for pulmonary arterial hypertension. The findings identified specific changes in muscle biology across different fiber types and nominated potential druggable targets and biomarkers. This research establishes foundational knowledge for developing targeted therapies to improve exercise capacity in patients with pulmonary arterial hypertension. Article 2: National utilization and outcomes of heart transplantation using ex situ machine perfusion. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40645313 Summary: This national study evaluated the utilization and outcomes of ex situ machine perfusion for heart transplantation in the United States, including adult recipients between October 2018 and September 2023 from the United Network for Organ Sharing database. The researchers compared outcomes between machine perfusion and non-machine perfusion transplants from both donation after brain death (D.B.D.) and donation after circulatory death (D.C.D.) donors. The findings revealed increasing adoption of machine perfusion and provided pragmatic national data on its effectiveness and patient outcomes. This research demonstrates the growing impact and success of machine perfusion in expanding the donor pool and optimizing heart transplantation. Article 3: Heart transplantation in Ukraine during wartime: A retrospective cohort study of standard vs marginal donor heart transplantation outcomes

Welcome to Cardiology Today – Recorded November 01, 2025. This episode summarizes 5 key cardiology studies on topics like heart failure with reduced ejection fraction and pressure-volume hemodynamics. Key takeaway: Video Kinematics Predict Donor Heart Function. Article Links: Article 1: Transthyretin Cardiac Amyloidosis Evaluation and Management: 2025 ACC Concise Clinical Guidance. (Journal of the American College of Cardiology) Article 2: A Novel Computational Pipeline for Acquiring Pressure-Volume Hemodynamics of the Right Ventricle in Pulmonary Hypertension. (JACC. Heart failure) Article 3: Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of CRD-740, a PDE9 Inhibitor, in Chronic Heart Failure. (JACC. Heart failure) Article 4: Serum Magnesium and the Effect of Empagliflozin in Heart Failure With Reduced Ejection Fraction: Findings From EMPEROR-Reduced. (JACC. Heart failure) Article 5: Video kinematics of an unloaded, ex-vivo beating heart can predict future loaded heart function. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/video-kinematics-predict-donor-heart-function-11-01-25/ Featured Articles Article 1: Transthyretin Cardiac Amyloidosis Evaluation and Management: 2025 ACC Concise Clinical Guidance. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41171219 Summary: The 2025 American College of Cardiology Concise Clinical Guidance addresses the evaluation and management of transthyretin cardiac amyloidosis, a growing cause of heart failure, especially in older individuals. It highlights the increased recognition of this condition, particularly in patients presenting with musculoskeletal issues like bilateral carpal tunnel syndrome or spinal stenosis. The guidance emphasizes substantial advances in noninvasive diagnostic capabilities that allow for accurate identification of transthyretin cardiac amyloidosis. These developments are crucial for improving timely diagnosis and guiding effective management strategies for heart failure patients. Article 2: A Novel Computational Pipeline for Acquiring Pressure-Volume Hemodynamics of the Right Ventricle in Pulmonary Hypertension. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41171248 Summary: This study developed a novel artificial intelligence-based computational pipeline designed to estimate load-independent right ventricular functional indices in patients with pulmonary hypertension. The method utilizes a pressure-time waveform and stroke volume data obtained from clinical right-sided heart catheterization. The objective was to simplify the acquisition of these crucial prognostic indicators for right ventricular dysfunction. This advancement has the potential to integrate these valuable metrics into everyday practice, improving prognostication and management for patients with pulmonary hypertension. Article 3: Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of CRD-740, a PDE9 Inhibitor, in Chronic Heart Failure. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41171251 Summary: This Phase 2, randomized, double-blind, placebo-controlled study investigates C.R.D.-740, an oral phosphodiesterase nine inhibitor, in patients with chronic heart failure with reduced ejection fraction. The study’s primary objective is to assess C.R.D.-740’s effects on plasma and urinary cyclic guanosine monophosphate levels. By inhibiting phosphodiesterase nine, the drug aims to increase intracellular cyclic guanosine monophosphate signaling, thereby enhancing beneficial natriuretic peptide receptor activation. This research explores a novel pharmacological strategy that could potentially improve treatment outcomes for individuals with heart failure with reduced ejection fraction. Article 4: Serum Magnesium and the Effect

Welcome to Cardiology Today – Recorded October 31, 2025. This episode summarizes 5 key cardiology studies on topics like natriuresis-guided therapy and echocardiography. Key takeaway: Vutrisiran Reduces Mortality in A.T.T.R. C.M.. Article Links: Article 1: The utility of urine biomarkers in diuretic resistance prediction in heart failure hospitalization. (ESC heart failure) Article 2: Outpatient loop diuretic use and the effect of natriuresis-guided diuretic therapy: A prespecified sub-analysis of the PUSH-AHF study. (European journal of heart failure) Article 3: Efficacy and safety of vutrisiran in transthyretin amyloid cardiomyopathy across the age spectrum: The HELIOS-B trial. (European journal of heart failure) Article 4: Fully Automatic AI-Based Quantification of LV Mass in Echocardiography: A Multimodality Validation. (JACC. Cardiovascular imaging) Article 5: Vericiguat in Chinese patients with heart failure and reduced ejection fraction: a real-world prospective study. (Cardiology) Full episode page: https://podcast.explainheart.com/podcast/vutrisiran-reduces-mortality-in-a-t-t-r-c-m-10-31-25/ Featured Articles Article 1: The utility of urine biomarkers in diuretic resistance prediction in heart failure hospitalization. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41163405 Summary: This study aimed to assess the predictive ability of urine biomarkers for loop diuretic resistance in patients hospitalized with heart failure. Researchers included consecutive patients with congestive heart failure hospitalization, defining congestion as oedema, ascites, or pleural effusion. Loop diuretic resistance was specifically defined as persistent congestion on the fourth day of hospitalization despite high intravenous loop diuretic doses. The research established a methodology to evaluate whether specific urine biomarkers could predict this resistance, which is known to be associated with worse clinical outcomes. Article 2: Outpatient loop diuretic use and the effect of natriuresis-guided diuretic therapy: A prespecified sub-analysis of the PUSH-AHF study. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41159496 Summary: study. This prespecified sub-analysis of the PUSH-A.H.F. study investigated the impact of outpatient loop diuretic use on natriuresis and clinical outcomes in patients hospitalized with acute decompensated heart failure. The study also aimed to determine if natriuresis-guided therapy could modify these effects, addressing a critical question regarding the efficacy of this approach in patients on chronic loop diuretics. Diuretic resistance is common in this population, and natriuresis-guided therapy has shown potential to overcome it. This research provides a crucial evaluation of how chronic loop diuretic use influences the effectiveness of natriuresis-guided strategies. Article 3: Efficacy and safety of vutrisiran in transthyretin amyloid cardiomyopathy across the age spectrum: The HELIOS-B trial. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41159479 Summary: This prespecified analysis of the H.E.L.I.O.S.-B trial evaluated the efficacy and safety of vutrisiran in transthyretin amyloid cardiomyopathy across various age categories. The main H.E.L.I.O.S.-B trial previously demonstrated that vutrisiran significantly reduced all-cause mortality and recurrent cardiovascular events compared to placebo in patients with this progressive condition. The sub-analysis specifically assessed outcomes in patients categorized by age: under 75, 75 to under 80, and 80 years or older, as well as across age as a continuous measure. This research is crucial for understanding how vutrisiran’s established benefits extend to the older adult population, who are predominantly affected by transthyretin amyloid cardiomyopathy and at higher risk of morbidity and mortality. Article 4: Fully Automatic AI-Based Quantification of LV

Welcome to Cardiology Today – Recorded October 31, 2025. This episode summarizes 5 key cardiology studies on topics like dietary recommendations and diet. Key takeaway: Elevated Blood Pressure Tied to Dementia Risk.. Article Links: Article 1: Combined Adaptive Immune Mechanisms Mediate Cardiac Injury After COVID-19 Vaccination. (Circulation) Article 2: Genetic evaluation of early-onset atrial fibrillation: impact on patient management. (European heart journal) Article 3: Dementia risk across blood pressure categories: a South Korean nationwide study. (European heart journal) Article 4: Diet and Clinical Outcomes in a Heart Failure Population. (JACC. Heart failure) Article 5: Cardioimmunologic response patterns after an acute heart failure event: Design and first results of AHF-ImmunoCS. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/elevated-blood-pressure-tied-to-dementia-risk-10-31-25/ Featured Articles Article 1: Combined Adaptive Immune Mechanisms Mediate Cardiac Injury After COVID-19 Vaccination. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41164857 Summary: This study investigated the previously elusive pathogenesis of acute myopericarditis (A.M.P.) developing after m.R.N.A. (messenger R.N.A.) COVID-19 vaccination. Researchers conducted in-depth phenotyping of peripheral blood T cells in patients who experienced acute myopericarditis post-vaccination. The findings definitively establish that combined adaptive immune mechanisms are responsible for mediating cardiac injury in these cases. This research provides critical understanding of this rare complication, strengthening the safety profile of m.R.N.A. vaccines by elucidating the biological mechanisms involved. Article 2: Genetic evaluation of early-onset atrial fibrillation: impact on patient management. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41166358 Summary: This study aimed to define the specific results and therapeutic impact of genetic evaluation for patients with early-onset atrial fibrillation (A.fib) referred to a dedicated precision medicine clinic. Patients diagnosed with atrial fibrillation before age 60 underwent a comprehensive assessment, including a three-generation pedigree, cardiac imaging, and ambulatory monitoring, in addition to standard evaluations. The research revealed that thorough genetic evaluation significantly impacts the management of early-onset atrial fibrillation, providing actionable information for personalized therapeutic strategies. This work underscores the value of precision medicine approaches for improving outcomes in specific atrial fibrillation populations. Article 3: Dementia risk across blood pressure categories: a South Korean nationwide study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41165161 Summary: This nationwide Korean cohort study analyzed 2800000 adults aged 40 years or older to clarify dementia risk associated with the newly introduced ‘elevated blood pressure’ category from the 2024 European Society of Cardiology (E.S.C.) guidelines. Participants with prior dementia or related conditions were excluded to ensure robust analysis. The study successfully defined specific dementia risks across various blood pressure categories, including systolic blood pressure 120-139 m.m. H.g. or diastolic blood pressure 70-89 m.m. H.g. These findings provide crucial evidence for the clinical implications of the new E.S.C. classification, highlighting the importance of managing blood pressure for cognitive health even before it reaches hypertensive levels. Article 4: Diet and Clinical Outcomes in a Heart Failure Population. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41165628 Summary: This multinational substudy from the G-C.H.F. (Global Congestive Heart Failure) registry involved 3798 participants across 25 countries to investigate the associations between specific

Welcome to Cardiology Today – Recorded October 30, 2025. This episode summarizes 5 key cardiology studies on topics like lifestyle and statistical shape atlases. Key takeaway: Randomized Evidence for Atrial Fibrillation Success. Article Links: Article 1: Aggressive Risk Factor Reduction Study for Atrial Fibrillation Implications for Ablation Outcomes: The ARREST-AF Randomized Clinical Trial. (JAMA cardiology) Article 2: Cardiovascular disease-specific and all-cause mortality across socioeconomic status and lifestyles among patients with established cardiovascular disease in communities of China: data from a national population-based cohort. (Heart (British Cardiac Society)) Article 3: Prevalence, spectrum and aetiology of valvular heart disease based on community echocardiographic screening transition from different altitudes in Yunnan, China. (Heart (British Cardiac Society)) Article 4: Longitudinal cardiac imaging for assessment of myocardial injury in non-hospitalised community-dwelling individuals after COVID-19 infection: the Rotterdam Study. (Heart (British Cardiac Society)) Article 5: Relationship between left ventricular shape and cardiovascular risk factors: comparison between the Multi-Ethnic Study of Atherosclerosis and UK Biobank. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/randomized-evidence-for-atrial-fibrillation-success-10-30-25/ Featured Articles Article 1: Aggressive Risk Factor Reduction Study for Atrial Fibrillation Implications for Ablation Outcomes: The ARREST-AF Randomized Clinical Trial. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41160038 Summary: The ARREST-AF Randomized Clinical Trial is an open-label, multicenter, randomized clinical trial with 12-month follow-up designed to determine the impact of risk factor and weight management on atrial fibrillation ablation rhythm outcomes. This study specifically addresses the need for randomized clinical trial evidence to support observational reports of reduced arrhythmia recurrence after atrial fibrillation ablation with aggressive lifestyle modification. By investigating this relationship, the ARREST-AF trial aims to establish whether lifestyle interventions can significantly improve the long-term success of atrial fibrillation ablation. This will provide crucial data for enhancing treatment strategies for patients with atrial fibrillation. Article 2: Cardiovascular disease-specific and all-cause mortality across socioeconomic status and lifestyles among patients with established cardiovascular disease in communities of China: data from a national population-based cohort. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40081938 Summary: This national population-based cohort study, conducted across 31 provinces in mainland China, investigated cardiovascular disease-specific and all-cause mortality among patients with established cardiovascular disease. Researchers included participants aged 35 to 75 years with self-reported diagnoses, collecting detailed information on socioeconomic status and lifestyle. The study aims to provide crucial evidence regarding socioeconomic status-related health inequality in cardiovascular disease patients who require both lifestyle changes and medical care, particularly in developing countries. This research will establish a clearer understanding of health disparities to inform targeted public health interventions. Article 3: Prevalence, spectrum and aetiology of valvular heart disease based on community echocardiographic screening transition from different altitudes in Yunnan, China. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40032496 Summary: This study investigated the prevalence, spectrum, and etiology of valvular heart disease across different altitudes in Yunnan Province, China, utilizing two sequential community-based echocardiography screening programs. The re

Welcome to Cardiology Today – Recorded October 30, 2025. This episode summarizes 5 key cardiology studies on topics like nitric oxide and Familial hypercholesterolemia. Key takeaway: Early F.H. Diagnosis Via Newborn Blood Spots. Article Links: Article 1: Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction. (The New England journal of medicine) Article 2: PCI of Native Coronary Artery vs Saphenous Vein Graft After Prior Bypass Surgery: A Multicenter, Randomized Trial. (Journal of the American College of Cardiology) Article 3: Nuclear eNOS Interacts With and S-Nitrosates ADAR1 to Modulate Type I Interferon Signaling and Endothelial Function. (Circulation) Article 4: Geometric Features of Ventricular Tachycardia Corridors in Patients With Ischemic Cardiomyopathy. (Circulation) Article 5: Genetic Diagnosis of Familial Hypercholesterolemia in Residual Newborn Dried Blood Spots. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/early-f-h-diagnosis-via-newborn-blood-spots-10-30-25/ Featured Articles Article 1: Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41159879 Summary: This international, investigator-initiated, open-label, randomized controlled trial was designed to compare immediate percutaneous coronary intervention guided by instantaneous wave-free ratio with deferred percutaneous coronary intervention guided by cardiac stress magnetic resonance imaging. The study enrolled patients with S.T.-segment elevation myocardial infarction and multivessel disease. This research establishes a robust methodology to determine the optimal timing for treating nonculprit lesions in these high-risk patients. The findings from this trial will provide critical evidence to guide clinical practice for nonculprit-lesion management in S.T.-segment elevation myocardial infarction. Article 2: PCI of Native Coronary Artery vs Saphenous Vein Graft After Prior Bypass Surgery: A Multicenter, Randomized Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41159978 Summary: The PROCTOR multicenter randomized trial was designed to compare clinical outcomes between percutaneous coronary intervention of the native coronary artery versus percutaneous coronary intervention of the saphenous vein graft. This study enrolled patients with prior coronary artery bypass grafting who presented with saphenous vein graft failure. This randomized comparison directly addresses a gap in current guidelines, which rely solely on observational data for recommendations regarding percutaneous coronary intervention strategy after bypass surgery. The findings will establish evidence-based guidance for optimal revascularization in this complex patient population. Article 3: Nuclear eNOS Interacts With and S-Nitrosates ADAR1 to Modulate Type I Interferon Signaling and Endothelial Function. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41159282 Summary: This research assessed the role of nuclear endothelial nitric oxide synthase and nitric oxide signaling for endothelial cell function. Using loss-of-function approaches, confocal microscopy, and biochemical analyses, the study found that endothelial nitric oxide synthase localized in the endothelial cell nucleus generates nitric oxide. This nuclear endothelial nitric oxide synthase interacts with and S-nitrosates Adenosine Deaminase, R.N.A.-Specific, 1, consequently modulating type I interferon signaling. These findings reveal a novel molecular mechanism through which nuclear endothelial nitric oxide synthase regulates vascular inflammation and endothelial homeostasis, offering new therapeutic avenues for endothelial dysfunction. Article 4: Geometric Features of Ventricular Tachycardia Corridors in Patients With Ischemic Cardiomyopathy. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/4

Welcome to Cardiology Today – Recorded October 29, 2025. This episode summarizes 5 key cardiology studies on topics like large hemispheric infarction and lower-extremity peripheral vascular interventions. Key takeaway: COVID-19 Vaccine Effects on High-Risk Hearts. Article Links: Article 1: Procedural Volume and Outcomes in Lower-Extremity Peripheral Vascular Interventions: Insights From the NCDR Peripheral Vascular Intervention Registry. (Journal of the American Heart Association) Article 2: Safety and Feasibility of YC-6 in Patients With Large Hemispheric Infarction: A Randomized Clinical Trial. (Journal of the American Heart Association) Article 3: Association of Pancreas Volume With Adverse Clinical Outcomes. (Journal of the American Heart Association) Article 4: Treatment Response and Survival in Methamphetamine-Associated Pulmonary Arterial Hypertension. (Journal of the American Heart Association) Article 5: COVID-19 Vaccination and Cardiovascular Outcomes in Older Adults With Coronary Artery Disease and Heart Failure: Insights From a Large Propensity-Matched Cohort Study. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/covid-19-vaccine-effects-on-high-risk-hearts-10-29-25/ Featured Articles Article 1: Procedural Volume and Outcomes in Lower-Extremity Peripheral Vascular Interventions: Insights From the NCDR Peripheral Vascular Intervention Registry. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147410 Summary: This study utilized the National Cardiovascular Data Registry Peripheral Vascular Intervention registry to investigate the relationship between hospital and operator procedural volume and in-hospital major adverse limb events and major adverse cardiovascular events following lower-extremity peripheral vascular interventions. It assessed data collected from April 1 2014 to December 31 2019 to better understand how provider experience influences patient safety and outcomes. This research establishes a clearer understanding of volume-outcome associations, which is crucial for standardizing care and potentially improving patient prognosis in peripheral artery disease management. Article 2: Safety and Feasibility of YC-6 in Patients With Large Hemispheric Infarction: A Randomized Clinical Trial. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147407 Summary: This randomized, double-blind, placebo-controlled, proof-of-concept clinical trial investigated the safety and preliminary feasibility of YC-6, specifically 5alpha-androst-3beta56beta-triol for injection, in patients experiencing large hemispheric infarction. The study enrolled individuals with middle cerebral artery infarction within 12 hours of symptom onset, addressing the urgent need for novel neuroprotective agents to combat malignant cerebral edema. By assessing these initial parameters, the research lays foundational groundwork for future therapeutic development, aiming to improve outcomes for a critical cause of poor prognosis in severe stroke. Article 3: Association of Pancreas Volume With Adverse Clinical Outcomes. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147404 Summary: This study investigated the association of pancreas volume with adverse clinical outcomes, recognizing that chronic diseases can reduce pancreas size and impact endocrine and exocrine function. Researchers estimated baseline age-adjusted predicted pancreas volume using abdominal magnetic resonance imaging data from 36592 U.K. Biobank participants. The analysis establishes a critical understanding of whether reduced pancreas volume serves as an indicator for heightened risk of various adverse clinical conditions. This research contributes a significant marker for potentially identifying individuals at higher risk, enabling earlier monitoring or preventive strategies. Article 4:

Welcome to Cardiology Today – Recorded October 29, 2025. This episode summarizes 5 key cardiology studies on topics like M.I.N.O.C.A. and multiomics. Key takeaway: A.E.D. Training Boosts Cardiac Arrest Survival.. Article Links: Article 1: Stratified treatment of myocardial infarction with non-obstructive coronary arteries: the PROMISE trial. (European heart journal) Article 2: Adaptation of right ventricular function following tricuspid transcatheter edge-to-edge repair. (ESC heart failure) Article 3: Improved Survival With Automated External Defibrillator-Only Training in a Public-Access Defibrillation Program: A 23-Year Database Analysis of Progetto Vita. (Journal of the American Heart Association) Article 4: A Multiomics Approach to Defining Target-Organ Injury in Youths With Primary Hypertension: The SHIP AHOY Cohort. (Journal of the American Heart Association) Article 5: GATA2 Mediates Macrophage Proliferation During Atherosclerosis. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/a-e-d-training-boosts-cardiac-arrest-survival-10-29-25/ Featured Articles Article 1: Stratified treatment of myocardial infarction with non-obstructive coronary arteries: the PROMISE trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41150941 Summary: The P.R.O.M.I.S.E. trial is a multicenter randomized study designed to evaluate the optimal management strategy for myocardial infarction with non-obstructive coronary arteries, or M.I.N.O.C.A. This condition is associated with significant mortality, rehospitalization, and angina burden, yet no prior randomized clinical trials had assessed its treatment. The trial’s objective is to determine if a stratified treatment approach improves clinical outcomes for M.I.N.O.C.A. patients compared to standard care. This research establishes a crucial framework to guide future clinical practice for this high-risk patient population. Article 2: Adaptation of right ventricular function following tricuspid transcatheter edge-to-edge repair. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147662 Summary: This study characterized changes in right ventricular ejection fraction, or R.V.E.F., following tricuspid transcatheter edge-to-edge repair, or T-T.E.E.R. Patients with significant tricuspid regurgitation underwent T-T.E.E.R. and cardiac magnetic resonance, or C.M.R., imaging, with follow-up C.M.R. performed within one to three months. The research aimed to clarify the impact of T-T.E.E.R. on right ventricular remodeling and its prognostic implications. By classifying patients based on postprocedural R.V. data, this work provides a clearer understanding of right ventricular adaptation after T-T.E.E.R., which is vital for assessing patient outcomes. Article 3: Improved Survival With Automated External Defibrillator-Only Training in a Public-Access Defibrillation Program: A 23-Year Database Analysis of Progetto Vita. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147502 Summary: This 23-year database analysis of the Progetto Vita, or P.V., program in Piacenza demonstrates improved survival for out-of-hospital cardiac arrest, or O.H.C.A., using automated external defibrillator, or A.E.D.,-only training. The P.V. project pioneered the first community-based A.E.D. program in Europe, and this extensive analysis provides critical survival data. The study highlights that early defibrillation is crucial for managing fatal arrhythmias, and A.E.D. use effectively minimizes time to defibrillation. This finding underscores the significant public health benefit of simplified A.E.D.-only training in public-access defibrillation programs for enhancing O.H.C.A. survival. Article 4: A Multiomics Approach to Defining Target-Organ Injury in Youths With Primary Hypertension: The SHIP AHOY Cohort. Journal: Journal of the American Heart Association PubMed Link: http

Welcome to Cardiology Today – Recorded October 28, 2025. This episode summarizes 5 key cardiology studies on topics like cardiac fibrosis and neurodevelopmental outcomes. Key takeaway: Nup35 Controls Heart Remodeling. Article Links: Article 1: Neurodevelopmental Outcomes in Early Adolescence: The Pediatric Heart Network’s Single Ventricle Reconstruction Trial. (Circulation) Article 2: Effect of Remote Ischemic Preconditioning on Myocardial Injury in Noncardiac Surgery: The PRINCE Randomized Clinical Trial. (Circulation) Article 3: The Role of the Collateral Circulation in Stable Angina: An Invasive Placebo-Controlled Study. (Circulation) Article 4: Cardiomyocyte Nucleoporin 35 regulates pathological cardiac remodeling through Wif1. (Cardiovascular research) Article 5: New insights into foam cells in atherosclerosis. (Cardiovascular research) Full episode page: https://podcast.explainheart.com/podcast/nup35-controls-heart-remodeling-10-28-25/ Featured Articles Article 1: Neurodevelopmental Outcomes in Early Adolescence: The Pediatric Heart Network’s Single Ventricle Reconstruction Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40671650 Summary: This study from the Pediatric Heart Network’s S.V.R. I.I.I. trial evaluated neurodevelopmental and functional outcomes in early adolescence for survivors of hypoplastic left heart syndrome. It enrolled adolescents who were randomized to different surgical shunt types during the Norwood procedure as neonates, conducting multifaceted in-person assessments. The research provides critical long-term follow-up data on the impact of initial surgical approaches on these significant morbidities. This comprehensive evaluation is crucial for informing care strategies and improving long-term quality of life for this vulnerable patient population. Article 2: Effect of Remote Ischemic Preconditioning on Myocardial Injury in Noncardiac Surgery: The PRINCE Randomized Clinical Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40511609 Summary: The multinational P.R.I.N.C.E. randomized clinical trial investigated the effect of remote ischemic preconditioning on myocardial injury during noncardiac surgery. Adult high-risk patients were randomly assigned to receive either remote ischemic preconditioning, involving three five-minute cycles of upper limb ischemia, or sham treatment after anesthesia induction. This robust, double-blind study aimed to definitively determine if remote ischemic preconditioning decreases postoperative myocardial injury and other complications. The trial establishes crucial evidence regarding the utility of remote ischemic preconditioning in improving outcomes for patients undergoing major noncardiac surgical procedures. Article 3: The Role of the Collateral Circulation in Stable Angina: An Invasive Placebo-Controlled Study. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41144984 Summary: This n-of-one invasive placebo-controlled study explored the relationship between myocardial ischemia, collateral circulation, and angina symptoms in stable coronary artery disease. Fifty-one participants with severe single-vessel coronary artery disease and angina were recruited for this investigation. The research aimed to clarify why the burden of ischemia often shows little correlation with angina severity and to explore the association between progressive collateral recruitment and ischemic preconditioning. This study provides a detailed understanding of the collateral circulation’s role in modulating symptoms and offering ischemic protection in stable angina patients. Article 4: Cardiomyocyte Nucleoporin 35 regulates pathological cardiac remodeling through Wif1. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41145234 Summary: This research identified Cardiomyocyte Nucleoporin 35 as a key regulator of pathological cardiac remodeling. The study demonstrated that cardiac

Welcome to Cardiology Today – Recorded October 28, 2025. This episode summarizes 5 key cardiology studies on topics like PARTNER 3 trial and ESPRIT trial. Key takeaway: PREVENT Equations Refine Blood Pressure Control.. Article Links: Article 1: Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years. (The New England journal of medicine) Article 2: Using PREVENT Equations to Compare Intensive vs Standard Systolic Blood Pressure Control for Primary Prevention in SPRINT. (Journal of the American College of Cardiology) Article 3: Effect of Intensive Blood Pressure Control on Stroke: A Prespecified Secondary Analysis of the ESPRIT Trial. (Journal of the American College of Cardiology) Article 4: Clinical Practice of Surgical Treatment for Left-Sided Infective Endocarditis: Nationwide Data from the NIDUS Registry. (Circulation) Article 5: Long-Term Outcomes of Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation: A Propensity Analysis. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/prevent-equations-refine-blood-pressure-control-10-28-25/ Featured Articles Article 1: Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41144631 Summary: This study from the PARTNER 3 trial aimed to provide longer-term clinical outcomes and valve durability assessments up to 7 years for low-risk patients with severe, symptomatic aortic stenosis. Patients were randomly assigned in a 1:1 ratio to undergo either transfemoral transcatheter aortic-valve replacement (T.A.V.R.) or surgical aortic-valve replacement. Prior 5-year data from this trial demonstrated similar outcomes between the two procedures. The research underscores the importance of continued long-term evaluation for valve durability and clinical effectiveness in these patients. Article 2: Using PREVENT Equations to Compare Intensive vs Standard Systolic Blood Pressure Control for Primary Prevention in SPRINT. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41125318 Summary: This secondary analysis of the SPRINT trial aimed to quantify the relative and absolute benefits and harms of intensive versus standard systolic blood pressure (S.B.P.) treatment using the new Predicting Risk of Cardiovascular Disease Events (PREVENT) equations. The PREVENT equations provide enhanced risk stratification by integrating estimated glomerular filtration rate, omitting race, and encompassing total cardiovascular disease events including heart failure. This research established a method for more precisely comparing intensive versus standard S.B.P. control by varying cardiovascular risk levels. The study demonstrates the utility of the PREVENT equations in refining primary prevention strategies for cardiovascular disease. Article 3: Effect of Intensive Blood Pressure Control on Stroke: A Prespecified Secondary Analysis of the ESPRIT Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40864014 Summary: This prespecified secondary analysis of the ESPRIT trial evaluated the effects of intensive blood pressure control on stroke outcomes. Hypertensive patients with elevated cardiovascular risk were randomized to either intensive treatment, targeting systolic blood pressure (S.B.P.) below 120 millimeters of mercury, or standard treatment, aiming for S.B.P. below 140 millimeters of mercury. The study investigated the comparative impact of these two blood pressure management strategies on preventing stroke. This research highlights the critical role of S.B.P. reduction in stroke prevention, providing a focused comparison of intensive versus standard therapeutic approaches. Article 4: Clinical Practice of Surgical Treatment for Left-Sided Infective Endocarditis: Nationwide Data from the NIDUS Registry. Jour

Welcome to Cardiology Today – Recorded October 27, 2025. This episode summarizes 5 key cardiology studies on topics like cardiovascular outcomes and N.R.4.A.2. Key takeaway: Targeting P2Y14R Prevents Venous Thrombosis. Article Links: Article 1: Short-Term Anticoagulation versus Dual Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure: The ANDES Randomized Clinical Trial. (Circulation) Article 2: Targeting P2Y14R alleviates platelet-induced NET formation and venous thrombosis through PKA/AKAP13/RhoA axis. (European heart journal) Article 3: Role of Stress-Responsive NR4A2 in Aldosterone-Producing Cell Cluster Formation. (Hypertension (Dallas, Tex. : 1979)) Article 4: Treating Malignant Hypertension With the Low-Sodium, Low-Protein, and Low-Fat Rice Diet. (Hypertension (Dallas, Tex. : 1979)) Article 5: Estrogen Influences Human Microvascular Endothelial Function Via Sex-Specific Regulation of Sphingolipids. (JACC. Basic to translational science) Full episode page: https://podcast.explainheart.com/podcast/targeting-p2y14r-prevents-venous-thrombosis-10-27-25/ Featured Articles Article 1: Short-Term Anticoagulation versus Dual Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure: The ANDES Randomized Clinical Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41139402 Summary: The A.N.D.E.S. Randomized Clinical Trial prospectively compared antithrombotic strategies after transcatheter left atrial appendage closure for patients with non-valvular atrial fibrillation. This multicenter international study randomized patients to either anticoagulation or dual antiplatelet therapy to determine the optimal approach for preventing device-related thrombosis. The trial’s objective was to establish which treatment strategy more effectively mitigates device-related thrombosis post-procedure. This research provides crucial evidence to guide clinical practice, potentially improving patient safety and outcomes following left atrial appendage closure. Article 2: Targeting P2Y14R alleviates platelet-induced NET formation and venous thrombosis through PKA/AKAP13/RhoA axis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41143464 Summary: This study investigated the role of the P2Y14 receptor, highly expressed on neutrophils, in venous thromboembolism. Researchers discovered that the P2Y14 receptor mediates neutrophil extracellular trap formation, which exacerbates thrombo-inflammatory responses and venous thromboembolism. Critically, targeting the P2Y14 receptor successfully alleviated platelet-induced neutrophil extracellular trap formation and venous thrombosis by modulating the P.K.A. / A.K.A.P.13 / R.h.o.A. axis. These findings establish the P2Y14 receptor as a promising therapeutic target for developing new strategies to combat venous thromboembolism. Article 3: Role of Stress-Responsive NR4A2 in Aldosterone-Producing Cell Cluster Formation. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41140167 Summary: This study investigated the mechanisms driving aldosterone-producing cell cluster formation, which are frequently observed in primary aldosteronism. Researchers utilized an integrated analysis of spatial transcriptomics and single-cell ribonucleic acid sequencing on aldosterone-producing cell clusters, aldosterone-producing adenomas, and zona glomerulosa cells. The study aimed to elucidate the role of the stress-responsive N.R.4.A.2 gene in this process. Establishing a clearer understanding of these mechanisms provides a foundational basis for developing new diagnostic and therapeutic strategies for primary aldosteronism and related hypertension. Article 4: Treating Malignant Hypertension With the Low-Sodium, Low-Protein, and Low-Fat Rice Diet. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41140152 Summary: This retrospe

Welcome to Cardiology Today – Recorded October 27, 2025. This episode summarizes 5 key cardiology studies on topics like melanocortin receptor accessory protein 2 and transcatheter heart valve. Key takeaway: Tirzepatide Stops Chemo Heart Damage. Article Links: Article 1: Loss of melanocortin receptor accessory protein 2 in melanocortin-4 receptor neurons protect from obesity-associated autonomic and cardiovascular dysfunctions. (Cardiovascular research) Article 2: Tirzepatide alleviates doxorubicin-induced cardiotoxicity via inhibiting HRD1-mediated Nrf2 ubiquitination. (Cardiovascular research) Article 3: Insights Into Early Adoption and Physician Learning Curve of Pulsed Field Ablation in the United States. (Circulation. Arrhythmia and electrophysiology) Article 4: Impact of Pullback Pressure Gradient on Clinical Outcomes after Percutaneous Coronary Interventions. (Circulation. Cardiovascular interventions) Article 5: Five-Year Clinical Outcomes and Durability of a Self-Expanding Transcatheter Heart Valve With Intra-Annular Leaflets. (Circulation. Cardiovascular interventions) Full episode page: https://podcast.explainheart.com/podcast/tirzepatide-stops-chemo-heart-damage-10-27-25/ Featured Articles Article 1: Loss of melanocortin receptor accessory protein 2 in melanocortin-4 receptor neurons protect from obesity-associated autonomic and cardiovascular dysfunctions. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40244925 Summary: This study investigated the role of melanocortin receptor accessory protein 2, or M.R.A.P.2, in melanocortin-4 receptor, or M.C.4.R., neurons regarding metabolic, autonomic, and cardiovascular functions. Researchers selectively deleted M.R.A.P.2 in M.C.4.R. neurons, finding that while this caused obesity and impaired glucose homeostasis, it also surprisingly protected against obesity-associated autonomic and cardiovascular dysfunctions. This research identifies M.R.A.P.2 in M.C.4.R. neurons as a significant regulator, offering a potential therapeutic target to decouple obesity from its cardiovascular complications. Article 2: Tirzepatide alleviates doxorubicin-induced cardiotoxicity via inhibiting HRD1-mediated Nrf2 ubiquitination. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40036855 Summary: This study investigated how tirzepatide, a gastric inhibitory polypeptide / glucagon-like peptide-1 receptor agonist, mitigates doxorubicin-induced cardiotoxicity, a major limitation in cancer therapy. Researchers discovered that tirzepatide effectively alleviates cardiotoxicity by inhibiting H.R.D.1-mediated nuclear factor erythroid 2-related factor 2, or N.R.F.2, ubiquitination, providing a crucial mechanistic understanding. This finding establishes tirzepatide as a promising pharmacological candidate to prevent or treat life-threatening cardiac damage from doxorubicin. Article 3: Insights Into Early Adoption and Physician Learning Curve of Pulsed Field Ablation in the United States. Journal: Circulation. Arrhythmia and electrophysiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41133296 Summary: This study, the D.I.S.R.U.P.T.-A.F. registry, described the early adoption and physician learning curve of pulsed field ablation, or P.F.A., for atrial fibrillation in the United States. It prospectively evaluated acute procedural efficiency, safety outcomes, and clinical workflow patterns for both paroxysmal and nonparoxysmal atrial fibrillation cases. This research provides essential real-world data on the initial U.S. experience with P.F.A., establishing baselines for its application and informing future training and optimization strategies. Article 4: Impact of Pullback Pressure Gradient on Clinical Outcomes after Percutaneous Coronary Interventions. Journal: Circulation. Cardiovascular interventions PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41137850 Summary: This post-hoc analysis of the P.P.G. Global study aimed to evaluate the prognostic

Welcome to Cardiology Today – Recorded October 27, 2025. This episode summarizes 5 key cardiology studies on topics like hypertensive disorders of pregnancy and pathogenic variant. Key takeaway: Trimetazidine for Early Hypertrophic Cardiomyopathy. Article Links: Article 1: Recaticimab in adult heterozygous familial hypercholesterolaemia (REMAIN-3): a multicentre, randomized, double-blind, placebo-controlled Phase 3 study. (Cardiovascular research) Article 2: Effects of iron deficiency anaemia on maternal haemodynamics and cardiac function in pregnant spontaneously hypertensive rats. (Cardiovascular research) Article 3: The pioneer factor, ETV2, regulates networks to specify the embryonic endothelial lineage. (Cardiovascular research) Article 4: YY1 regulates vascular resistance and blood pressure dynamics through epigenetic control of m6A RNA modifications in vascular smooth muscle cells. (Cardiovascular research) Article 5: Effect of trimetazidine dihydrochloride therapy on myocardial external efficiency in pre-clinical individuals with a hypertrophic cardiomyopathy pathogenic variant: results of the ENERGY trial. (Cardiovascular research) Full episode page: https://podcast.explainheart.com/podcast/trimetazidine-for-early-hypertrophic-cardiomyopathy-10-27-25/ Featured Articles Article 1: Recaticimab in adult heterozygous familial hypercholesterolaemia (REMAIN-3): a multicentre, randomized, double-blind, placebo-controlled Phase 3 study. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40911402 Summary: The REMA.I.N.-3 study was a multicenter, randomized, double-blind, placebo-controlled Phase 3 trial. It assessed the efficacy and safety of recaticimab, a new humanized anti-Proprotein Convertase Subtilisin/Kexin type 9 antibody. This drug targets reduction of low-density lipoprotein cholesterol levels in adults with poorly controlled heterozygous familial hypercholesterolaemia. This research provides crucial data regarding a potential new therapeutic agent for this genetic disorder. Article 2: Effects of iron deficiency anaemia on maternal haemodynamics and cardiac function in pregnant spontaneously hypertensive rats. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40878014 Summary: This study investigated the effects of iron deficiency anemia on maternal hemodynamics and cardiac function during pregnancy. Researchers utilized pregnant spontaneously hypertensive rats and normotensive controls to understand how iron deficiency interacts with hypertensive disorders of pregnancy. This research is critical for determining whether iron deficiency ameliorates or exacerbates maternal cardiovascular dysfunction in these high-risk pregnancies. Establishing this relationship could inform better management strategies for pregnant patients. Article 3: The pioneer factor, ETV2, regulates networks to specify the embryonic endothelial lineage. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40832854 Summary: This study elucidated the role of E.T.V.2, a pioneer transcription factor, in specifying the embryonic endothelial lineage. Researchers uncovered the specific transcriptional and epigenetic changes orchestrated by E.T.V.2 to promote hematoendothelial lineage development. Concurrently, E.T.V.2 was shown to suppress other mesodermal cell fates, precisely directing differentiation. This fundamental research significantly advances our understanding of cardiovascular development and lineage specification, offering potential avenues for regenerative strategies. Article 4: YY1 regulates vascular resistance and blood pressure dynamics through epigenetic control of m6A RNA modifications in vascular smooth muscle cells. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40795179 Summary: modifications in vascular smooth muscle cells. This study established that the transcription factor Y.Y.1 directly regulates vascular resistance a