Join us on the latest episode! Our Guest: Frank Bedu-Addo, President and CEO at PDS Biotechnology Corporation.

What you'll get out of this episode:

• PDS Biotechnology targets the key limitations of CAR T and cancer vaccine therapies using lipid nanoparticle-based immunotherapy.
• Their lead candidate, PDS0101, demonstrated over 2x improvement in survival for HPV-positive head and neck cancer.
• The platform technology shows consistent efficacy across multiple independent Phase 2 trials.
• Late-stage clinical programs focus on HPV16+ head and neck cancer, with additional trials for colorectal, prostate, and MUC1+ cancers.

To Learn More About Our Guest And Their Company:
Guest LinkedIn https://www.linkedin.com/in/frank-bedu-addo-4797947/
Company LinkedIn https://www.linkedin.com/company/pds-biotechnology-corporation/
Website https://www.pdsbiotech.com/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Michael Demurjian, Founder & CEO at Aspargo Laboratories.

What you'll get out of this episode:

• Aspargo tackles inefficiencies in pill-based drug delivery through innovative oral suspensions.
• The company’s patented technology improves absorption via buccal and GI routes.
• First commercial product, HisQ (oral spray sildenafil), delivers rapid ED treatment in just 10 minutes—even on a full stomach.
• Future products include sprays for weight loss and hair loss, launching via a telehealth platform.
• Upcoming smart dispenser connects with physicians and caregivers for enhanced adherence and monitoring.

To Learn More About Our Guest And Their Company:
Guest LinkedIn https://www.linkedin.com/in/michael-demurjian-02868113/
Company LinkedIn https://www.linkedin.com/company/aspargo-laboratories-inc/
Website https://aspargolabs.com/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Michael Oleksiw, CEO at Pleio.

What you'll get out of this episode:

• Human + AI Synergy: Pleio combines emotionally aware AI with peer-to-patient support to boost medication adherence.
• Overcoming Emotional Barriers: Emotions like fear, loneliness, and stigma are major challenges after diagnosis.
• Real-World Impact: Pleio's approach improved adherence rates by up to 28% in GLP-1 medication trials.
• Ethical AI in Healthcare: Patient data is de-identified and overseen by a medical board to ensure ethical use.
• Laser Focus on Loneliness: Pleio’s next frontier is tackling loneliness as a primary emotional barrier in healthcare.

To Learn More About Our Guest And Their Company:
Guest LinkedIn https://www.linkedin.com/in/michaeloleksiw/
Company LinkedIn https://www.linkedin.com/company/pleio-inc/
Website http://www.pleio.com

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Bill Peters, CEO at On Target Laboratories.

What you'll get out of this episode:

• Innovative Imaging for Surgery – On Target Laboratories enables surgeons to see cancer at the cellular level using near-infrared imaging.
• Cytalux for Lung & Ovarian Cancer – Their FDA-approved drug, Cytalux, helps identify tumors in real-time, improving surgical outcomes.
• Surgeon-Driven Development – Continuous feedback from surgeons drives research, refining the technology for broader applications.
• Future of Cancer Surgery – With ongoing clinical trials, On Target Laboratories aims to expand its imaging technology to new indications.
• Industry Engagement – The company actively participates in key medical conferences, connecting with experts to advance cancer care.

To Learn More About Our Guest And Their Company:
Guest LinkedIn https://www.linkedin.com/in/bill-peters-749a332a/
Company LinkedIn https://www.linkedin.com/company/on-target-laboratories-inc/
Website http://www.ontargetlabs.com

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Frank Watanabe, President & CEO at Arcutis Biotherapeutics.

What you'll get out of this episode:

• Company Focus: Arcutis Biotherapeutics, under Frank Watanabe, is dedicated to treating inflammatory skin conditions, with three FDA-approved products and a fourth pending.
• Significant Milestones: This year, Arcutis launched two new products and partnered with a primary care company to expand its reach.
• Patient-Centric Approach: Arcutis prioritizes patient needs by involving dermatology practitioners and patient insights directly in decision-making.
• Technological Perspective: While acknowledging AI's potential in drug discovery, Arcutis is focused on tangible, current advancements without prematurely implementing AI.
• Expanding Accessibility: Arcutis is actively working to extend its treatments to Medicare and Medicaid markets to support a broader patient demographic.

To Learn More About Our Guest And Their Company:
LinkedIn https://www.linkedin.com/in/frank-watanabe-419711/
Company LinkedIn https://www.linkedin.com/company/arcutis-inc/
Website https://www.arcutis.com/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guests: Aaron Mackey, SVP of AI/Data Science at Lokavant & Jonathan Crowther, Head of Predictive Analytics at Pfizer.

What you'll get out of this episode:

• Causal AI Explained: Aaron Mackey from Lokavant and Jonathan Crowther from Pfizer discuss the capabilities of causal AI in differentiating cause and effect in clinical trials.
• Comparison to Generative AI: The episode breaks down the distinctions between generative AI and causal AI, highlighting the advantages of causal approaches in clinical operations.
• Impact on Clinical Trial Feasibility: The experts explain how causal AI optimizes trial feasibility assessments, leading to more efficient and effective clinical processes.
• Forecasting Clinical Trials with AI: Insight into how causal AI improves data-driven decision-making and addresses the limitations of traditional trial forecasts.

To learn more about our guests and their companies:
Aaron's LinkedIn https://www.linkedin.com/in/aaronmackey/
Jonathan's LinkedIn https://www.linkedin.com/in/crowtherjonathan/

Lokavant LinkedIn https://www.linkedin.com/company/lokavant/
Pfizer LinkedIn https://www.linkedin.com/company/pfizer/

Lokavant Website https://www.lokavant.com/en-us/
Pfizer Website https://www.pfizer.com/

Our sponsor for this episode is:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Joerg Ahlgrimm, CEO at SK Pharmteco.

What you'll get out of this episode:

• Joerg Ahlgrimm discusses his journey in the pharmaceutical industry and his role at SK Pharmteco.
• The strategic integration of companies under SK Pharmteco to enhance global CDMO capabilities.
• The importance of a patient-centric approach in driving company success and innovation.
• Challenges and strategies for ensuring operational efficiency and overcoming funding difficulties in biotech.
• Ahlgrimm’s advice for emerging leaders on career growth and maintaining a patient-first focus.

To Learn More About Our Guest And Their Company:
LinkedIn https://www.linkedin.com/in/joerg-ahlgrimm-315a925/
Company LinkedIn https://www.linkedin.com/company/skpharmteco/
Website https://www.skpharmteco.com/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Elliott Green, Co-Founder & CEO at Dandelion Health.

What you'll get out of this episode:

• Elliot Green's transition from Oscar Health to founding Dandelion Health.
• Dandelion Health's innovative approach to real-world data and clinical AI.
• The importance of longitudinal data in advancing precision medicine.
• The potential of AI to accelerate drug development and improve healthcare outcomes.
• Upcoming events where Dandelion Health will share their advancements.

To Learn More About Our Guest And Their Company:
LinkedIn https://www.linkedin.com/in/elliott-green-98433b2/
Company LinkedIn https://www.linkedin.com/company/dandelion-health-ai/
Website https://dandelionhealth.ai/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Nicole K. Paulk, CEO & Founder at Siren Biotechnology.

What you'll get out of this episode:

• Nicole Paulk's early inspiration in gene therapy during her PhD at OHSU.
• The transition from academia to entrepreneurship amid COVID-19.
• Siren Biotechnology's innovative approach with AAV immunogene therapy.
• The challenges and successes in securing funding and navigating regulatory landscapes.
• The exciting transition of Siren Biotechnology from preclinical to clinical trials.

To Learn More About Our Guest And Their Company:
LinkedIn https://www.linkedin.com/in/nicolepaulk/
Company LinkedIn https://www.linkedin.com/company/siren-biotechnology-inc/
Website https://sirenbiotechnology.com/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Sam Cooper, Co-Founder & CTO at Phenomic.

What you'll get out of this episode:

• Sam Cooper shares his journey from Imperial College London to founding Phenomic.
• Phenomic's innovative approach combines AI with biological research.
• The company focuses on developing drugs targeting the tumor stroma.
• Phenomic's partnership with TileDB and Boehringer Ingelheim.
• Advice for budding biotech entrepreneurs from Sam Cooper.

To Learn More About Our Guests and their Companies:
LinkedIn https://www.linkedin.com/in/sam-cooper-537814134/
Company LinkedIn https://www.linkedin.com/company/phenomic/
Website https://phenomic.ai/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guests: Christine Senn, PhD, the SVP of Site-Sponsor Innovation at Advarra & Rohit Nambisan, Co-Founder and CEO at Lokavant.

What you'll get out of this episode:

• Rohit Nambisan discusses Lokavant's approach to leveraging AI in clinical trial feasibility.
• Christine Senn highlights the importance of thorough feasibility processes in rare disease trials.
• The need for diverse site participation and data inputs to improve trial accuracy and efficiency.
• The role of AI and technology in enhancing clinical trial processes.

To learn more about our guests and their companies:
Christine's LinkedIn https://www.linkedin.com/in/christinesenn/
Rohit's LinkedIn https://www.linkedin.com/in/rohitnambisan/

Advarra LinkedIn https://www.linkedin.com/company/advarra/
Lokavant LinkedIn https://www.linkedin.com/company/lokavant/

Advarra Website https://www.advarra.com/
Lokavant Website https://www.lokavant.com/en-us/

Our sponsor for this episode is:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Dr. Sam Clark, Founder and CEO at Terran Biosciences.

What you'll get out of this episode:

• Revolutionizing Treatments: Dr. Sam Clark discusses Terran Biosciences' mission to innovate treatments for neurological and psychiatric conditions.
• Innovative Drug Development: The company focuses on creating new mechanisms for treating depression, bipolar disorder, and schizophrenia.
• Smaller, Agile Teams: Terran Biosciences operates with a flat structure, utilizing highly trained experts to solve complex problems.
• Addressing Patent Monopolies: The company aims to break patent monopolies in pharma through innovative approaches and pro-drug strategies.
• Exciting Developments: Dr. Clark teases upcoming announcements, including long-acting and improved drug forms.

To learn more about our guests and their companies:
LinkedIn https://www.linkedin.com/in/sam-clark-md-phd-133139199/
Company LinkedIn https://www.linkedin.com/company/terran/
Website https://terranbiosciences.com/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Dr. Michael Kyle, SVP & Chief Medical Officer at Currax Pharmaceuticals.

What you'll get out of this episode:

• Dr. Michael Kyle's Background: Insights into his journey from medical practice to becoming SVP & Chief Medical Officer of Currax Pharmaceuticals.
• Understanding Obesity: A discussion on different types of obesity and the importance of tailored treatments.
• Global Perspectives: Comparing how the U.S. and European countries handle obesity and the lessons to be learned.
• Evolving Treatments: The parallel evolution of hypertension and obesity treatments.
• Behavioral Approaches: The importance of sustainable lifestyle changes and behavior modification in addressing obesity.

To learn more about our guests and their companies:
LinkedIn https://www.linkedin.com/in/michael-l-kyle/
Company LinkedIn https://www.linkedin.com/company/currax-pharmaceuticals-llc/
Website https://www.curraxpharma.com/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Colin Weller, VP & GM of Evidence Platform at Medable.

What you'll get out of this episode:

• Introduction of Colin Weller: Vice President and GM of Evidence Platform at Medable, Colin Weller discusses his role in advancing clinical research technology to streamline drug approvals.
• Challenges in Drug Development: Weller details the stagnant pace of drug development, highlighting the industry's need for innovation to improve efficiency and reduce costs.
• Medable's Ambitious Goals: Aiming to increase the number of drugs approved annually by tenfold through advanced SAS technology and AI, setting a new industry standard.
• Innovations in Clinical Trials: Medable has already cut study startup times by 50%, utilizing AI and automation to overhaul traditional processes.
• Future of Digital Clinical Trials: Weller predicts significant advancements in decentralized and digital trials, enhancing patient accessibility and data quality.

To learn more about our guests and their companies:
LinkedIn: https://www.linkedin.com/in/colin-weller-294ab58/
Company LinkedIn: https://www.linkedin.com/company/medable-inc-/
Website: https://www.medable.com/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Stella K. Vnook, CEO at Likarda.

What you'll get out of this episode:

• Stella Vnook, CEO of Likarda, discusses her transition from a science background to the business side of biotech and her journey to becoming CEO.
• Likarda specializes in core-shell spherification, creating beads with cells for targeted drug delivery, improving viability and efficacy.
• The company aims to enhance cell therapies, especially in liver cells and hormone therapy, and simplify cell transport logistics.
• Likarda's future goals include launching off-the-shelf products for osteoarthritis and advancing partnerships in cell therapy and regenerative medicine.
• Funding strategies and future plans involve a Series A funding round, non-dilutive funding, and efficient use of resources to scale up and innovate.

To learn more about our guests and their companies:
LinkedIn: https://www.linkedin.com/in/vnook/
Company LinkedIn: https://www.linkedin.com/company/likarda-llc/
Website: https://likarda.com/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Samantha Dale Strasser, CEO & Co-Founder at Pepper Bio.

What you'll get out of this episode:

• Samantha Dale Strasser, co-founder and Chief Science Officer of Pepper Bio, shares her transition from academia to entrepreneurship, driven by a personal mission to change healthcare outcomes.
• Pepper Bio, located in Boston, leverages transomics to integrate multiple data sets for precision medicine, aiming to treat diseases that are currently untreatable.
• Strasser’s focus is on developing treatments for challenging diseases, with an emphasis on oncology, inflammatory diseases, and neurodegenerative disorders.
• Pepper Bio’s approach in drug discovery combines its own pipeline development with strategic partnerships, speeding up the process of bringing new treatments to the clinic.
• The company has made significant strides in identifying novel targets and shelved assets, leading to a high success rate in in vivo model validations.

To learn more about our guests and their companies:
LinkedIn: https://www.linkedin.com/in/samantha-dale-strasser/
Company LinkedIn: https://www.linkedin.com/company/pepperbio/
Website: https://pepper.bio/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Cary Claiborne, CEO of Adial Pharmaceuticals.

What you'll get out of this episode:

• Meet Cary Claiborne: Discover the visionary CEO behind Adial Pharmaceuticals.
• Understanding AD04: Dive into the science of this promising new treatment for alcohol use disorder.
• The Impact of Alcohol Use Disorder: A closer look at the challenges and the need for better treatments.
• A Glimpse into the Future: Explore how AD04 could revolutionize addiction treatment beyond alcohol use disorder.
• Adial's Mission and Vision: Hear directly from Claiborne about the company's path forward and commitment to innovation.

To learn more about our guests and their companies:
LinkedIn: https://www.linkedin.com/in/cary-claiborne-sr-84a2217/
Company LinkedIn: https://www.linkedin.com/company/adialpharma/
Website: https://www.adial.com/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Marcio Souza, CEO of Praxis Precision Medicines.

What you'll get out of this episode:

• Discussion on innovative CNS drug development on BioBreakthroughs podcast.
• Learn about Praxis' genetics-inspired approach to tackling complex brain diseases.
• Souza highlights the challenges and opportunities in CNS treatment, including the impactful EMBOLD and EMBRAVE studies.
• Discover Praxis Precision Medicines' future prospects and their commitment to revolutionizing patient care in the CNS field.

To learn more about our guests and their companies:
LinkedIn: https://www.linkedin.com/in/marcio-souza-2b02837/
Company LinkedIn: https://www.linkedin.com/company/praxis-precision-medicines-inc/
Website: https://praxismedicines.com/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Steve Reed, Co-Founder & Chief Executive Officer Of HDT Bio

What you'll get out of this episode:

• Reed shares his 40-year journey in microbiology and immunology.
• Discussion on HDT Bio's approach to vaccine development for infectious diseases and cancer.
• Insight into the Amplify vaccine platform and its impact on global health.
• Reed's perspective on vaccine accessibility and affordability.
• Preview of HDT Bio's upcoming projects in oncology.

To learn more about our guests and their companies:
LinkedIn: https://www.linkedin.com/in/steven-reed-b23b159b/
Company LinkedIn: https://www.linkedin.com/company/hdt-bio/
Website: https://www.hdt.bio/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/

Join us on the latest episode! Our Guest: Gadi Saarony, CEO of Advarra

What you'll get out of this episode:

• Discussing the challenges in clinical research and strategies for overcoming them.
• Exploring the role of technology in modern clinical trials.
• Advarra's innovative approach to streamlining clinical research processes.
• Insights on the future of clinical trials and healthcare innovation.
• Key takeaways from the discussion and implications for the industry.

To learn more about our guests and their companies:
LinkedIn: https://www.linkedin.com/in/gadi-saarony/
Company LinkedIn: https://www.linkedin.com/company/advarra/
Website: https://www.advarra.com/

Our sponsor for this episode are:
Sage Growth Partners https://sage-growth.com/

BioBreakthroughs is part of the Slice of Healthcare podcast network:
LinkedIn: https://www.linkedin.com/company/sliceofhealthcare/