Alexander Disease Research Update

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Alexander Disease Research Update

Albee Messing

28 episodes

2 days ago

Albee Messing, Tracy Hagemann, and Abby Olsen discuss the following recent publication: [01:45] Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease Annals of Clinical and Translational Neurology (in press) [full text] Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: ...

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Health & Fitness

All content for Alexander Disease Research Update is the property of Albee Messing and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.

Albee Messing, Tracy Hagemann, and Abby Olsen discuss the following recent publication: [01:45] Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease Annals of Clinical and Translational Neurology (in press) [full text] Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: ...

Show more...

Health & Fitness

Episodes (20/28)

Alexander Disease Research Update

Alexander Disease Research Update - Episode #28: GDF15, nausea, vomiting, and "failure to thrive"

Albee Messing, Tracy Hagemann, and Abby Olsen discuss the following recent publication: [01:45] Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease Annals of Clinical and Translational Neurology (in press) [full text] Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: ...

2 days ago

26 minutes

Alexander Disease Research Update

Alexander Disease Research Update – Episode #27: Genotype-phenotype association for 14 GFAP variants

Albee Messing, Mel Feany, and Natasha Snider discuss the following recent publication: Genotype-phenotype association for 14 GFAP variants in Alexander disease. Neurology: Genetics. 11, e200270 (2025) [full text] Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: https://alexander-disease.waisman.wisc.edu/donate/ ...

4 months ago

32 minutes

Alexander Disease Research Update

Alexander Disease Research Update – Episode #26: Changes in gene expression and cognitive function in the rat model

Albee Messing, Tracy Hagemann, and Rob Berman discuss the following recent publication: [02:01] GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease eNeuro (in press) [full text] Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: &nb...

7 months ago

28 minutes

Alexander Disease Research Update

Alexander Disease Research Update – Episode #25: GFAP Variants in the UK Biobank - estimated prevalence of adult-onset AxD

Albee Messing, Charlie Wade, and Mel Feany discuss the following recent publication: [01:50] Analysis of GFAP variants in UK Biobank suggests underdiagnosis or incomplete penetrance of adult-onset Alexander disease Journal of Neurology, Neurosurgery, and Psychiatry (in press) Please send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: &...

9 months ago

27 minutes

Alexander Disease Research Update

Alexander Disease Research Update – Episode #24: 1) iPS cell model with aberrant development and 2) unusual variant in GFAP affecting the eye

Albee Messing and Natasha Snider discuss the following recent publications: [01:04] Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease Glia (2024) (in press) [16:46] A novel GFAP frameshift variant identified in a family with optico-retinal dysplasia and vision impairment Human Molecular Genetics (2024) (in press) Send your questions and feedbac...

11 months ago

28 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #23: Albee Messing's presentation at the recent conference in Philadelphia

Albee Messing’s presentation at the recent Alexander disease conference in Philadelphia, August 3, 2024. Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: https://alexander-disease.waisman.wisc.edu/donate/

1 year ago

22 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #22: 1) anesthesia and AxD, and 2) GFAP cross-linking to itself

Albee Messing, Amy Waldman, and Natasha Snider discuss the following recent publications: [02:07] A retrospective observational cohort study of the anesthetic management and outcomes of pediatric patients with Alexander disease undergoing lumbar puncture or magnetic resonance imaging Paediatric Anesthessia (in press) [10:17] Glial fibrillary acidic protein is patholog...

1 year ago

20 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #21: 1) Blood levels of GFAP, neurofilaments, and tau, and 2) planning for in-person conference in Philadelphia this summer.

Albee Messing, Jenny Pearson, Natasha Snider, and Amy Waldman discuss the following recent publication and the conference planned for this summer in Philadelphia: [02:02] Plasma concentrations of glial fibrillary acidic protein, neurofilament light, and tau in Alexander disease Neurological Sciences (2024) [full text] [04:16] Discussion about Philadelphia Conference, August 2-4, 2024 ...

1 year ago

15 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #20: 3D bioprinting method for co-culture of neurons and astrocytes reveals new features of Alexander disease

Albee Messing and Linghai Kong discuss the following recent publication: [01:52] 3D bioprinting of human neural tissues with functional connectivity. Cell Stem Cell 31:260-274.e7 (2024) [full text] Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: https://alexander-disease.waisman.wisc.edu/donate/ ...

1 year ago

15 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #19: Giant Axonal Neuropathy and Alexander Disease

Albee Messing, Rachel Battaglia, and Natasha Snider discuss the following publication: [00:59] Intermediate filament dysregulation in astrocytes in the human disease model of KLHL16 mutation in giant axonal neuropathy (GAN) Molecular Biology of the Cell (in press) [full text - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846626/] Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of W...

1 year ago

18 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #18: 1) Quantitative MRI in rat model, and 2) Developmental milestones in cerebral form of AxD

Albee Messing, Nick Stowe, JP Yu, and Amy Waldman discuss the following recent publications: [4:30] Stowe NA, Singh AP, Barnett BR, Yi SY, Frautschi PC, Messing A, et al. Quantitative diffusion imaging and genotype-by-sex interactions in a rat model of Alexander disease. Magnetic Resonance in Medicine (2023) in press [15:11] Acquisition and Loss of Developmental Milestones and Time to Disease-Related Outcomes in Cerebral Ale...

1 year ago

28 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #17: 1) new iPS cell line, 2) acetylation and GFAP, and 3) STAT3 as a key regulator driving GFAP accumulation

Albee Messing, Rachel Battaglia, and Tracy Hagemann discuss the following recent publications: [01:45] A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells Stem Cell Reports 18, 1701-1720 (2023) [includes new iPS cell line from an individual with Alexander disease] [full text] [05:39] Isolation of Intermediate Filament Proteins ...

2 years ago

24 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #16: Webinar - Guangping Gao lab

Webinar on the strategy and preliminary results for “AAV-mediated Gene Silencing for the Treatment of Alexander Disease” presented by Drs. Guangping Gao, Jun Xie, and Dominic Gessler from the University of Massachusetts Medical School. This version is audio only - the full video version will be made available later at a site that is not yet determined.

2 years ago

1 hour 8 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #15: subclassifications of Type I; questions regarding 1) mesenchymal stem cells and 2) the intransasal route of delivery

Albee Messing and Davide Tonduti discuss the following recent publication: [00:41] Type I Alexander Disease: Update and Validation of the Clinical Evolution-Based Classification Molecular Genetics and Metabolism 138, 107540, 2023 [16:01] Questions from email regarding mesenchymal stem cells for transplantation and the intranasal route for delivering therapeutics to the central nervous system. Send your questions and feedbac...

2 years ago

20 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #14: whole exome/genome sequencing; more questions on the brainstem

Albee Messing and Josh Bonkowsky discuss the following recent publication: [02:13] Identification of a novel de novo pathogenic variant in GFAP in an Iranian family with Alexander disease by whole-exome sequencing.European Journal of Medical Research 27, 174 (2022) [full text] [14:20] Questions from email regarding the brainstem in Alexander disease. Send your questions and feedback to: axdrupodcast@waisman.wisc.edu Help su...

3 years ago

18 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #13: MRI diffusion tractography - what can it tell us?

Albee Messing, Emi Takahashi, Arastoo Vossough, and Amy Waldman discuss the following recent publication: [02:03] Identification of association fibers using ex vivo diffusion tractography in Alexander disease brains Journal of Neuroimaging (in press) Send your questions and feedback to: axdrupodcast@waisman.wisc.edu

3 years ago

16 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #12: GFAP variants and oxidative stress/mitochondrial dysfunction; commentary on dizziness, risks of brain biopsies

Albee Messing, Rachel Battaglia, and Abby Olsen discuss the following recent publication: [01:00] Alexander disease GFAP R239C mutant shows increased susceptibility to lipoxidation and elicits mitochondrial dysfunction and oxidative stress (Redox Biology, 55:102415, 2022) [14:23] Questions from email regarding 1) dizziness and 2) risks of brain biopsies. Send your questions and feedback to: axdrupodcast@waisman.wisc.edu He...

3 years ago

25 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #11: neurology 101 (location, location, location), discussion on the autonomic nervous system

Albee Messing and Abby Olsen discuss the following recent publication: [03:04] Adult-onset Alexander disease: new causal sequence variant in the GFAP gene. (Neurology: Genetics, in press) [14:15] Autonomic nervous system – part 1 [26:09] Questions from email regarding connecting spinal cord problems and symptoms. [31:17] Autonomic nervous system – part 2 Send your qu...

3 years ago

33 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #10: effects of variants in the rod domain on GFAP assembly and aggregation, new ideas about functions of intermediate filaments

Albee Messing and Natasha Snider discuss the following recent publication: [04:44] Effects of Alexander disease-associated mutations on the assembly and organization of GFAP intermediate filaments (Molecular Biology of the Cell, in press) [28:53] Questions from email regarding heritability, penetrance, and skipping generations. Send your questions and feedback to: axdrupodcast@waisman.wisc.edu Help support research on Alexa...

3 years ago

34 minutes

Alexander Disease Research Update

Alexander Disease Research Update - Episode #9: new mechanisms of astrocyte dysfunction, case report with novel variant, commentary on head trauma as an aggravating factor

Albee Messing, Mel Feany, Florian Eichler, and Ming der Perng discuss the following recent publications: [02:21] Wang L et al. (2022) Anastasis drives senescence and non-cell autonomous neurodegeneration in the astrogliopathy Alexander disease. Journal of Neuroscience (in press) [reports interesting new mechanisms of astrocyte dysfunction] [18:42] Kang YR et al. (2022). A novel in-frame GFAP p.E138_L148del mutation ...

3 years ago

41 minutes