Matt Maiocco shares the 49ers’ injury update before sitting down with Greg Papa to recap San Francisco’s thrilling 26-23 overtime win over the Los Angeles Rams on Thursday night at SoFi Stadium and discuss how the victory can set the tone for the rest of the season.

An injured 49ers squad defied the odds and dug deep for a 26-23 overtime win over the Los Angeles Rams on Thursday at SoFi Stadium. Backup quarterback Mac Jones delivered his third win in three starts despite laboring through pain all game. Kyle Shanahan managed a very limited and at times inexperienced San Francisco squad, and rookies produced when their numbers were called. Matt Maiocco and Jennifer Lee Chan discuss how the 49ers have set themselves up well in the division with an undefeated start, and if a character-defining win like tonight can catapult them to their larger goals despite the early adversity they've experienced thus far.

John Lynch joins Matt Maiocco to break down the 49ers' first four games of the 2025 NFL season, from how San Francisco's rash of injuries affect his front-office priorities to some of the more positive on-field developments during their resilient start. Jennifer Lee Chan also joins Matt to preview the 49ers' Week 5 matchup vs. the NFC West rival Los Angeles Rams this Thursday at SoFi Stadium, and points out an area of vulnerability San Francisco could expose on a short week against a very potent opponent.

An afternoon of errors resulted in the 49ers' first loss of the 2025 NFL season Sunday against the Jacksonville Jaguars. Despite a second-half comeback attempt, San Francisco couldn't overcome its four turnovers. Brock Purdy's looked shaky in his return from injury after missing the last two weeks with turf toe. Matt Maiocco and Jennifer Lee Chan discuss how a subpar performance from all three phases contributed to the 49ers' first defeat. Matt and Jennifer also address the curious postgame exchange between 49ers defensive coordinator Robert Saleh and Jaguars coach Liam Coen as the topic of sign-stealing could be a season-long storyline.

Matt Maiocco speaks with 49ers coach Kyle Shanahan about San Francisco's Week 4 matchup vs. the Jacksonville Jaguars and also discusses Nick Bosa’s season-ending ACL injury. Greg Papa joins Matt to discuss defensive coordinator Robert Saleh’s comments about the Jaguars’ signal stealing and Brock Purdy returning from injury.

Despite their undefeated status, the Nick Bosa-less 49ers must persevere as the Jacksonville Jaguars visit Levi's Stadium this Sunday. Matt Maiocco and Jennifer Lee Chan discuss who will step up in Bosa's place and how San Francisco can adapt in other injury-bitten position groups. Plus, Matt and Jennifer detail how Demarcus Robinson will integrate back into the fold and how it affects the receiving corps. Finally, the nominees for the Pro Football Hall of Fame's Class of 2026 have been announced, and Matt and Jennifer choose the most outstanding former 49er candidates.

The 49ers have endured a rash of injuries to star players to start their season, and that list grew emphatically by one more player Monday morning following the news that defensive end Nick Bosa reportedly will have to undergo season-ending surgery to repair a torn ACL. On this emergency episode of '49ers Talk,' Matt Maiocco is joined by Carlos Ramirez to discuss the fallout from this massive injury. How will the 49ers proceed, who will step-up in place of the former NFL Defensive Player of the Year, can San Francisco bring in reinforcements externally and will that change their current strategy of roster-construction? Matt and Carlos tackle these tough questions as the undefeated 49ers must find answers just three weeks into the NFL regular season.

The 49ers' home opener against the Arizona Cardinals brought plenty of twists and turns as San Francisco emerged victorious to maintain its undefeated start with a thrilling 16-15 win. Kicker Eddy Piñeiro's game-winning field goal and Mac Jones' clinical two-minute drive got the 49ers over the hump in a gutsy win, improving San Francisco to 3-0 in the 2025 season. The win didn't come without its costs as star defensive end Nick Bosa exited the game with an apparent knee injury. Matt Maiocco and Jennifer Lee Chan break down the 49ers' courageous victory, Bosa's injury and how San Francisco's alleged weakness in depth has turned into their strength as they now sit atop the NFC West standings.

Matt Maiocco speaks with 49ers coach Kyle Shanahan about their Week 3 matchup vs. the Arizona Cardinals and discuss how Luke Farrell and Jake Tonges have stepped up after injuries to George Kittle and Kyle Juszczyk. Also Greg Papa joins Matt to breaks down how 49ers’ improved speed on defense can contain Kyler Murray.

Dee Winters' journey to starting 49ers linebacker opposite star Fred Warner didn't come without its bumps in the road. From past injuries to supplanting himself next to a dynamic duo of Warner and Dre Greenlaw, it was always going to be uphill. Winters, however, has weathered the storm and emerged as the promising player San Francisco hoped he would be when it drafted him in the sixth round of the 2023 NFL Draft. On this episode of "49ers Talk," Matt Maiocco sits down with the third-year pro to discuss his journey from humble beginnings to the primetime of 49ers football. Also, co-host Jennifer Lee Chan joins Matt to discuss injury updates to QB Brock Purdy and the other San Francisco stars, as well as preview the Week 3 lineup vs. the Arizona Cardinals.

Mac Jones might have rebooted his career in the 49ers' 26-21 win over the New Orleans Saints on Sunday at Caesars Superdome. Under the tutelage of San Francisco coach Kyle Shanahan, Jones looked the part of an NFL starting quarterback with a 279-yard, three-touchdown performance as an injured Brock Purdy watched from the sideline. Matt Maiocco and Jennifer Lee Chan break down how the 49ers' offense utilized Jones' arm early and often, and also identify which rookies stepped up amid injuries on both offense and defense ahead of next weekend's home opener against the Arizona Cardinals.

Matt Maiocco speaks with 49ers coach Kyle Shanahan about their Week 2 matchup vs. the New Orleans Saints and Mac Jones' San Francisco debut on Sunday in place of injured starting quarterback Brock Purdy. Also Greg Papa joins Matt to break down key matchups in this weekend's game.

The 49ers brought an end to the Jake Moody saga Tuesday by waiving the beleaguered kicker, opting to bring in veteran Eddy Piñeiro as his replacement. Matt Maiocco and Jennifer Lee Chan break down how San Francisco and Moody arrived to this point and how the 49ers will fare at this position moving forward. The duo also discusses Brock Purdy's pair of injuries and George Kittle's placement on injured reserve, as well as Kendrick Bourne's return. Then, Matt sits down with Jake Tonges' former high school coach to discuss the backup tight end's emergence from Los Gatos, Calif., to the pros.

The 49ers rallied late for a 17-13 comeback victory over the Seattle Seahawks on Sunday at Lumen Field. While San Francisco's defense produced several key performances, a surprising face on offense made the play of the game when third-string tight end Jake Tonges stepped up in George Kittle's injury absence. Matt Maiocco and Jennifer Lee Chan break down the roller-coaster ride that was the 49ers' Week 1 win, from outstanding defense and gritty offense to their erratic special-teams play.

Matt Maiocco speaks with San Francisco 49ers coach Kyle Shanahan about their Week 1 matchup vs. the Seattle Seahawks and why he's optimistic about Christian McCaffrey's health despite the star running back being listed as questionable for Sunday's game. Greg Papa also joins to provide an encouraging update on his cancer battle.

As 49ers quarterback Brock Purdy leads San Francisco into its 2025 NFL season opener, gone are the days of Mr. Irrelevant. Equipped with a lucrative new contract and a young family in tow, Purdy sits down "49ers Talk" host Matt Maiocco to discuss how he adjusts to all of these changes, including a complete roster overhaul this offseason. Brock and Matt touch upon what motivates the 25-year-old and he can take his game and the 49ers organization to the next level, one snap at a time.

With Sunday’s season opener against the Seattle Seahawks looming, Matt Maiocco and Jennifer Lee Chan discuss the latest updates on Jauan Jennings’ calf injury and contract extension negotiations, and debate if Jennings will suit up for the 49ers in Week 1. Also, Matt and Jennifer break down San Francisco's wide-receiver depth and detail what Brian Robinson Jr. brings to the team's run game.

With Tuesday's roster cutdown deadline officially passed, there were a few surprises for the 49ers at key positions. Matt Maiocco and Jennifer Lee Chan discuss their biggest takeaways from San Francisco's initial 53-man roster, from the ailing wide-receiver corps and heavily invested defensive line, to a special-teams group facing mounting pressure. Also, we'll hear from newly acquired running back Brian Robinson Jr., who is poised to make the 49ers' backfield the most potent in the league.

After the 49ers' 30-23 win over the Los Angeles Chargers in Saturday's preseason finale, their attention now turns to the 53-man roster deadline on Tuesday. Matt Maiocco and Jennifer Lee Chan discuss each position group's depth and how Kyle Shanahan, John Lynch and Co. will whittle the roster down. New additions Skyy Moore and Brian Robinson Jr. join the team as roster locks, but which players will be cut? Also, Matt sits down with NBC Sports Washington's JP Finlay to discuss what the Robinson trade brings to the 49ers' locker room.

With former 49ers coach Jim Harbaugh and the Los Angeles Chargers visiting Levi's Stadium for Saturday's preseason finale, San Francisco's final roster decisions are becoming more clear. Matt Maiocco and Jennifer Lee Chan discuss what will play into the 49ers' roster choices, including injury updates, player suspensions and position-group competitions. Also, Matt and Jennifer review how the entire 2025 NFL Draft class has fared throughout training camp, and discuss Kyle Shanahan's update on veteran wide receiver Demarcus Robinson's suspension following his violation of the NFL's personal conduct policy last season.