About this podcast:
This podcast dives deep into the fundamentals of antibody-drug conjugate design, specifically focusing on the selection of targeting antibodies, cytotoxic drugs, and linkers. Presenter Dr Deepa Pakianathan highlights key strategies for constructing ADCs and the critical differentiating features that enhance therapeutic efficacy and safety. 

For more information, go to IO360summit.com.

About this podcast:
This podcast comes from the 2025 Patients as Partners in Clinical Research conference. 

This panel discussion demonstrates how patient advocates are bridging the divide at the site level to improve patient representation in clinical trials. More specifically, this podcast focuses on: 

• Strategies for overcoming limited resources and lack of infrastructure, which can hinder inclusive clinical trial participation
• Successful models for empowering local leaders and leveraging community-based networks to increase participation
• Evaluating the impact of outreach and engagement efforts on enrollment representation and overall care equity
• And more

For more information, go to PatientsAsPartnersConference.com.

About this podcast: 
Liz Thompson, Global Development Leader, Senior Clinical Development Scientist at Roche, presented how the organization had delivered a single, cohesive protocol amendment categorization process to reduce the number of amendments and create a continuous improvement strategy, all to speed up timelines and reduce costs. This presentation comes from the September 2025 DPHARM: Disruptive Innovations to Modernize Clinical Research program. 

More specifically, Ms Thompson discusses how Roche is: 

• Leveraging historical amendment data to enable study teams to understand why protocols are being amended
• Utilizing a visual data science platform to generate insights from data to make better data-driven decisions
• Applying retrospective learning into current protocols to curb the need for amendments
• Building in business value 

For more information, go to DPHARMconference.com.

About this podcast:
This session was recorded at the September 2025 CRAACO: Clinical Research as a Care Option conference.

Rural sites represent untapped potential for reaching a broader array of patients and providing them access to life-changing clinical trials, but existing clinical trial infrastructure does not set rural sites up for success. 

Funded through the Genentech Innovation Fund, Montana State University and Billings Clinic created a rural clinical research readiness toolkit for unaffiliated rural and frontier healthcare systems to empower them to meet clinical research demands without compromising local care delivery.

More specifically, this presentation covers the tools created to toolkit empowers sites to do clinical research, including:

• Interpretable workflow templates
• A workload calculator for staff capacity planning
• Patient safety indicators to support enrollment and retention
• EHR-based visualization methods to assist clinical decision-making when trial participants are also patients
• And more

For more information, go to theconferenceforum.org.

This podcast features a panel discussion from the 2025 Chief Medical Officer Summit 360° with biotech CMOs about how CMOs can support value creation in biotechs and how that is influenced buy the current biotech financial climate. Specifically:

• The importance of storytelling and leading thoughtfully
• Effective prioritization and execution towards the company narrative
• Balancing the team to be lean while avoiding the potential pitfalls of running lean
• Balancing the data collected to be interesting to investigators and important for the program to proceed
• Clinical data generation is better than preclinical dreams
• Strategically choosing a first indication and building sufficient scientific bridging to support subsequent indications

To learn more about the Chief Medical Officer Summit 360°, please visit CMO360.org.

In this podcast from the DPHARM 2024 archives, Biogen discussed how they used an AI-enabled software to detect cognitive impairment and Alzheimer’s disease neuropathology, based on voice, to provide access to patients  with a clinically validated cognitive assessment who might not otherwise have the foundation to start a conversation with their physician about their cognition. 

For more information, go to DPHARMconference.com

At the March 2025 Patients as Partners conference, Merck presents how they advancing patient and community engagement through targeted initiatives designed to improve trial participation, relevance, and long-term impact. Key topics include:

• Identifying and addressing patient and community needs
• Strategies for earning trust and fostering sustained engagement
• Key collaborations and partnerships driving meaningful change
• Approaches to developing patient-centered endpoints and outcomes
• Methods for effectively communicating and disseminating trial results

For more information, go to PatientsAsPartnersConference.com

Summary: 

This session was recorded at the March 2025 Patients as Partners conference. In this session, Pfizer addressed how they were working to ensure continuity in the patient insights they were collecting, throughout the product life cycle. This included: 

• Approaches for aligning internal processes to facilitate the seamless flow of patient insights from early-phase to late-phase teams

• Suggested tools, including an AI Insights tool designed to centralize and leverage previous patient feedback, supporting a more integrated approach to patient engagement

• Strategies to build on existing insights, enhance collaboration across teams, and drive more effective patient-centered outcomes in R&D processes

For more information, go to PatientsAsPartnersConference.com.

Summary: 

From the DPHARM Archives, this podcast was recorded at the September 2024 DPHARM conference. In this podcast, BMS present how they specifically targeted the challenge of recruiting patients for clinical trials, aiming to make the process faster and easier. By bringing trials directly to patients, their ultimate objective was to significantly expedite patient enrollment. In this case example, they brought the audience through their new product model approach, for the organization's overarching goal of reducing the drug timeline from discovery to launch by three years.

About this podcast:
Recorded at the 2025 Immuno-Oncology 360º Summit, Stanford University's Dr Crystal Mackall shares work from her lab developing GD2-targeting CAR T cell therapy for the treatment of deadly pediatric brain tumor, as well as broader lessons on the evolution of cell therapy, and her forward-looking perspective on shaping the next generation of cancer treatments.

For more information, go to IO360summit.com. 

Summary:
Rescuing a clinical trial and choosing to switch vendor's mid-trial are some of the most expensive decisions biotech CMOs can make. These rescues require a significant amount of time, money and energy and may not even address the root issue behind a trial's poor performance. In this podcast, Raul Lima, SVP, Strategic Clinical Operations, inSeption Group, discusses a scaffolding approach that prioritizes areas that require immediate support without sacrificing the entirety of the trial. Specifically:

• How biotechs can better identify root causes of issues and correct them
• Mistakes CMOs make when implementing rescues
• When and how a scaffolding approach can be more resource, time and financially efficient

For more information about inSeption Group, visit inSeptionGroup.com. 

For more information about the annual Chief Medical Officer Summit 360° and its affiliated editorials, podcasts and webcasts, please visit CMO360.org.

Summary:
When developing patient-centric products for biologics, different doses, expressed by different combinations of volume/concentration may require different delivery devices. As a result, it takes a great deal of time and effort in planning and coordinating the formulation and device activities. In this podcast, Pharma and Drug Delivery executives from Nanoform, Pfizer, GSK, Takeda and Kymanox discuss how they facilitate partnerships between drug product development, device engineering and clinical study teams to determine how to balance concentration and volume and develop optimal devices for delivery and commercialization. Specifically:

• Impact on increasing concentration of drugs on deliverability
• Technical feasibility of manufacturing larger volume devices
• Patient tolerability and human factors that impact patient adherence

This panel discussion was recorded at the October 2024 PODD: Partnership Opportunities in Drug Delivery conference. For more information, go to Drug-Delivery.org.

In this podcast series, DPHARM Director Tracey Kimball with Valerie Bowling, Executive Director of the Conference Forum, break down what to expect at DPHARM 2025. Part III of this podcast series covers sessions addressing AI in Clinical Trials.

Summary:
Accessibility to CAR-T is limited by traditional manufacturing, with its associated challenges and high cost. Moffitt Cancer Center's Chief BioEngineering Officer, Dr Greg Sawyer, highlights Moffitt's significant progress in enhancing T cell potency and boosting efficacy through engineering strategies. Dr Sawyer discusses assays enabling precise asessment of T cell potency, developments in manufacturing, and more, and the resulting impact on scalability and efficiency. 

This presentation comes from the March 2025 Immuno-Oncology 360º Summit. For more information, go to IO360summit.com. 

Summary:
In this podcast, Pharma and Drug Delivery executives from Novartis, AstraZeneca, Merck and Quotient Sciences discuss traditional and novel approaches to improve the oral delivery of peptides including:

• The biopharmaceutics of oral peptide and the use of permeation enhancers
• Alternate sites for the delivery of oral peptides throughout the GI tract
• Improving oral exposure through ingestible devices 
• Delivering ASOs and other large synthetics
• Next-generation approaches for delivery

This presentation was recorded at the October 2024 PODD: Partnership Opportunities in Drug Delivery conference. For more information, go to Drug-Delivery.org.

Summary: 
In this podcast, Dr Anthony Yanni, SVP, Head of Patient Centricity at Astellas, presented the business rationale for patient-centric medicine development, how it's disrupting the pharmaceutical industry and why companies have to act swiftly to remain competitive. 

Dr Yanni discusses how to align medicine development with healthcare delivery and the necessary cultural transformation that is critical to sustaining it, practical steps to incorporate patient input early into the R&D process, operationalizing patient-centric processes, methods to measure impact, and more.

This presentation was recorded at the March 2025 Patients as Partners in Clinical Research conference. For more information, go to PatientsAsPartnersConference.com.

This podcast features a panel discussion from the 2025 Chief Medical Officer Summit 360° with biotech CMOs across indications about how CMOs can better develop drugs patients want and derisk development by partnering with patient organizations. Specifically, the panelists address:

• Patient voice driving drug development forward
• Supporting health equity and patient access after approval
• Building genuine relationships and engaging early to get to the right patients at the right time and for better advocacy about your research
• Building a community of awareness and working with patients for support throughout the regulatory process
• Integrating the patient perspective in early
• Real world examples and their impacts

To learn more about the Chief Medical Officer Summit 360°, please visit CMO360.org.

Summary:
In this session, pharma sponsors and sites gather to present innovative solutions to solve site challenges in workforce and capability gaps, increasing technology burden, patient enrollment and managing clinical trial protocol complexity. They discuss efforts to address those challenges, early impacts and outcomes. 

In this panel: 

• Dennis Salotti, MS, MBA, Executive Director & Head of Clinical Outsourcing & Innovation, Jazz Pharmaceuticals
• Kristin Herman, Executive Director, Clinical Trials Office, Sidney Kimmel Cancer Center, Jefferson Health
• Eileen Hughes, RN, BS, Senior Manager, Site Partnerships, CSL Behring
• Lisa Kiehne, SVP, Operations, The START Center for Cancer Research 
• Christopher McNair, PhD, Associate Director, Data Science and Cancer Informatics, Sidney Kimmel Cancer Center, Jefferson Health
• Tracey Robertson, Head of Patient and Site Engagement Capability Management, Boehringer Ingelheim 

This panel was recorded at the 2024 DPHARM: Disruptive Innovations to Advance Clinical Research. For more information about the 2025 DPHARM, visit DPHARMconference.com. 

Conference Forum Director Valerie Bowling and CRAACO Producer Danny McCarthy break down what to expect at the 2025 CRAACO program. This podcast covers the keynotes, panels and key themes for this year's event, including: 

• How to develop a clinical research program within a community cancer center, with Dr Brian Slomovitz, Mount Sinai Medical Center Miami Beach
• Turning clinical environments into learning health systems, with Dr Laura Esserman, UCSF Carol Franc Buck Breast Cancer Center
• How to better partner with multiple location health system structures for clinical trials 
• Addressing medical staff shortages and challenges to support clinical research
• The impact of clinical trial participation on cost and performance in cancer centers
• EHR and AI advancements for clinical research 
• And more 

Want to know more about CRAACO? Visit CRAACOevent.com.

PODD: Partnership Opportunities in Drug Delivery Directors Valerie Bowling and Andrew Goldstein break down what to expect at PODD 2025. This podcast covers keynotes and key themes for this year's event, including:

• Regeneron Co-Founder and CSO, Dr George Yancopoulos
• Novo Nordisk Chief Scientific Advisor, Dr Lotte Bjerre Knudsen
• MIT's Robert Langer
• Patient Keynote, Jimi Olaghere
• Northeastern University's Dr Mansoor Amiji
• Drug Delivery Technology Presentation Tracks
• Networking Opportunities
• and more

Want to know more about PODD? Check it out at PODDConference.com.