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In the Know with Amol Sarva
Amol Sarva
86 episodes
5 days ago
Amol Sarva's series with changemakers and innovators in longevity, tech, and ideas
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Business
Technology,
Science
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Amol Sarva's series with changemakers and innovators in longevity, tech, and ideas
Show more...
Business
Technology,
Science
Episodes (20/86)
In the Know with Amol Sarva
Owen Davis, Contour and NYC Seed
Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Owen Davis tells us how advertising powered early NYC tech and the big transition post-dot-com-crash to both consumer and enterprise tech superstars from New York.
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3 weeks ago
1 hour 10 minutes 31 seconds

In the Know with Amol Sarva
John Borthwick, Betaworks
Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. John Borthwick tells us the roots story of media and art and agencies at the heart of the early NY tech ecosystem and some of the players, and takes it through predictions for what to expect today.
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3 weeks ago
1 hour 10 minutes 29 seconds

In the Know with Amol Sarva
Pablos Holman from Deep Future VC on “invention” vs. just innovation
Pablos built one of the first decentralized money networks, the first experimental Blue Origin rockets, one of the first handheld computers, invented 1000s of new patents with Nathan Myhrvold, and most recently launched a deeptech venture firm called Deep Future. And now, on July 12, expect his book: "Deep Future". -- Pablos Holman and Amol on Deep Future Amol Sarva: [00:00:00] On today's episode, I'm excited to have my pal, Pablo Coleman from the future. Are we rolling? We are rolling. Right on. Bob, are we rolling? Bob? And we're gonna talk about, I don't know I think we should talk about a little bit of origin story before we get to the fund and the new book that's coming out. And I'm excited to be the first interviewer Yeah. That you've chosen to speak to  Pablos Holman: about your freshly. Finalized manuscript. We're gonna turn the tables. I'm gonna have you on my podcast sometime too. Yeah, that'd be great. Apparently you have, we should  Amol Sarva: have done right now, apparently you have hundreds  Pablos Holman: of listeners, I dunno, hundreds or thousands here. Here. Not hundreds of thousands  Amol Sarva: Here on this podcast we have the two of us who will listen to it be recorded. Hey, I'm  Pablos Holman: cool with that. I once had a radio show in Alaska and we had a full studio and we broadcast. But we had no antenna. The station had no antenna, but we had 24 hour a day broadcasting. So imagine like how esoteric and weird the DJs for a radio station are that have no listeners. Yeah. Like we had the best [00:01:00] parties.  Amol Sarva: Yeah. Wow. Then I guess let us begin then with the origin stories. Cool. You were born in Alaska? Apparently. I was born in  Pablos Holman: Alaska. Yeah. It's hard to find an Alaskan who's escaped from Alaska, but I'm one of 'em, I've literally never met anyone who's from Alaska. I know. Yeah. They make it about as far as Seattle and then they really feel like they've traveled and then they usually go back to Alaska. Very few Alaskans make it this far. So you made it to the great capital of Seattle across the I left Alaska, I went to Silicon Valley and then ended up, yeah, after the.com collapse, I retreated to Seattle. And but that was good. And Seattle was really good for a long time. Now I'm over it.  Amol Sarva: I, part of part of what's really cool about that experience, or at least that I quite admire, is you got to work with some of the real. Intellectual rock stars of the tech world. Certainly yeah, in the, I guess it would've been the two thousands, roughly. Yeah.  Pablos Holman: Yeah. After Silicon Valley I went to work I went to Seattle and I started Blue Origin or helped start Blue Origin with Jeff Bezos. Yeah. [00:02:00] And so that was great for me and an inflection point where I took all of the experience of bringing computer technology to life and trying to use the computers to bring other technologies to life. And so that's what. What I think of as deep tech.  Amol Sarva: Yeah. But how'd you even so what was the Silicon Valley tour of duty then that I  Pablos Holman: started out computer hacking when I was a kid. So when I was in Silicon Valley, it was really about trying to, use the, that skillset to bring new technologies. And, in the late, in the, like late eighties and early nineties, it was really just take computers into every industry for the first time. But then, once we started putting Muggles on the internet in 94, then I realized, oh shit, this is not gonna go very well. We need to secure things. So I started working on cryptographic protocols, trying to secure the internet. I worked on cryptocurrency in the nineties. Oh. And a precursor, flus or whatever. No, not that good. Flus is not a cryptocurrency. Flus was a. I guess you could say like digital currency, but No, I was [00:03:00] trying, small group of fringe wackos, cipher p
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4 months ago

In the Know with Amol Sarva
AI x Bio x NY: highlights from our conference
So you missed the all-day all-science+technology collection of superstars gathered by LifeX and Bits in Bio at Fenwick in New York? Wondering what the frontiers of foundation models in bio, longevity, startups and more are pushing? Now you can use the cheat code and just listen to this synopsis of the big highlights and discussion points.
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6 months ago
14 minutes 20 seconds

In the Know with Amol Sarva
What’s super-investor Jim Mellon thinking about?
Jim, founder of Juvenescence, old China and Russia hand, and investor in our fund LifeX sends me an email every morning with lots of attachments that he read that morning. Here's what he's been thinking about the last month.
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6 months ago
16 minutes 45 seconds

In the Know with Amol Sarva
De-growth, de-acceleration from the Slow Down manifesto by Shohei Saito, by Amolbot
Read the post here: https://amol.sarva.co/%f0%9f%90%8c-kohei-saitos-slow-down-de-acc-manifesto/
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6 months ago

In the Know with Amol Sarva
Cyborgs! Our AI and Bio Future, by Amolbot
I gave a talk in Stockholm last year, that I asked these robots to discuss. Hope you enjoy it. This doesn't look LIKE me but it does sort of resemble what I could possibly look like. It was the first draft. Some better prompting got us to the final image.
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7 months ago
24 minutes 4 seconds

In the Know with Amol Sarva
What’s Om Malik interested in these days?
The legendary tech beat reporter is back with a team effort newsletter covering some of the most interesting people in tech. Listen in to hear what he's been thinking about over the last 10 issues.
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9 months ago
24 minutes 23 seconds

In the Know with Amol Sarva
10 x Trends for AI x Health + Bio in 2025 from LifeX dealflow analysis, courtesy of Amolbot
We analyzed the 1,000s of companies we're watching and investing in at LifeX. We looked at every update email from every CEO and every conversation notes from every team member. And we made hits outlook for the year ahead, automagically. (Excuse robo-typos.) Enjoy!
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10 months ago
31 minutes 45 seconds

In the Know with Amol Sarva
20 Trends for 2025 in Health and Biopharma from Wall Street, synthesized by Amolbot
We synthesized the dozens of outlook reports from Wall Street analysts on health, biopharma, and related trends. Listen in to Amolbot (an automated Amol) and co-hosts.
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10 months ago
36 minutes 54 seconds

In the Know with Amol Sarva
Techbio 2025 predictions from Amol’s inbox full of reports, via Amolbot
10 months ago
48 minutes 4 seconds

In the Know with Amol Sarva
Soluble and insoluble fiber, food and gut health and their role in overall health with Dr. Will Bulsiewicz from Zoe
1 year ago
37 minutes 55 seconds

In the Know with Amol Sarva
How food becomes energy and the view from sports nutrition on metabolism with Professor Derek Huffman of Einstein
1 year ago
37 minutes 13 seconds

In the Know with Amol Sarva
Food as medicine with physician and founder Jeff Alfonsi
1 year ago
44 minutes 56 seconds

In the Know with Amol Sarva
Pro biotics, pre biotics, and what your digestive system knows with Maya Kaelberer, Ph.D.
1 year ago
30 minutes 9 seconds

In the Know with Amol Sarva
Metformin, Rapamycin, the cellular mechanisms at the cutting edge of weight loss and longevity with Matt Kaeberlein, Ph.D.
1 year ago
51 minutes 28 seconds

In the Know with Amol Sarva
Bariatric surgery, the gut biome, and the interactions that create weight loss with surgery and nutrition professor Randy Seeley, Ph.D. at Michigan
1 year ago
46 minutes 53 seconds

In the Know with Amol Sarva
Understanding blood sugar and insulin with world leader on diabetes Dr. John Buse of UNC
1 year ago
42 minutes 57 seconds

In the Know with Amol Sarva
How weight loss works with Yale’s Dr. Waj Mehal
1 year ago
36 minutes 52 seconds

In the Know with Amol Sarva
How Ozempic works and what else could revolutionize metabolic health with James Peyer, Ph.D. of Cambrian Bio
1 year ago
44 minutes 53 seconds

In the Know with Amol Sarva
Amol Sarva's series with changemakers and innovators in longevity, tech, and ideas