Future Pulse Cardiology

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Future Pulse Cardiology

Thomas Nero MD FACC

22 episodes

8 months ago

We would love to hear your thoughts on the episodes! Dr Thomas Nero discusses inflammation and the role of rheumatologic disorders on coronary artery disease with Dr Nehal Mehta, exploring how chronic inflammation serves as a cornerstone for various health issues, particularly in patients with conditions like psoriasis and serves as a model for investigating cardiovascular therapies. The discussion highlights the role of immune responses, the impact of lifestyle factors, and the importance of...

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Entrepreneurship,

Health & Fitness,

All content for Future Pulse Cardiology is the property of Thomas Nero MD FACC and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.

We would love to hear your thoughts on the episodes! Dr Thomas Nero discusses inflammation and the role of rheumatologic disorders on coronary artery disease with Dr Nehal Mehta, exploring how chronic inflammation serves as a cornerstone for various health issues, particularly in patients with conditions like psoriasis and serves as a model for investigating cardiovascular therapies. The discussion highlights the role of immune responses, the impact of lifestyle factors, and the importance of...

Show more...

Entrepreneurship,

Health & Fitness,

Episodes (20/22)

Future Pulse Cardiology

Inflammation and Cardio-Rheumatology with Dr Nehal Mehta

We would love to hear your thoughts on the episodes! Dr Thomas Nero discusses inflammation and the role of rheumatologic disorders on coronary artery disease with Dr Nehal Mehta, exploring how chronic inflammation serves as a cornerstone for various health issues, particularly in patients with conditions like psoriasis and serves as a model for investigating cardiovascular therapies. The discussion highlights the role of immune responses, the impact of lifestyle factors, and the importance of...

10 months ago

52 minutes

Future Pulse Cardiology

Coronary Inflammation Imaging with FAI Score on CT angiography with Prof. Stefan Neubauer

We would love to hear your thoughts on the episodes! Prof. Stefan Neubauer and Dr. Thomas Nero discuss two recent papers on the utility of coronary inflammation imaging on CT coronary angiography with Fat Attenuation Index (FAI)FAI score. The ORFAN study demonstrated a 20 fold increased risk in CV event rates with low vs high FAI score and a 10 fold increased event rate in patients with elevated FAI score who have no coronary plaque. FAI score re-categorized 40% of patients in their fol...

1 year ago

45 minutes

Future Pulse Cardiology

Trial Statistics, Trial Design and AI with Dr. C Michael Gibson

We would love to hear your thoughts on the episodes! Dr Gibson and Dr Nero discuss the oft maligned issue of medical statistics. Their discussion covers the pros and cons of traditional Cox proportional hazards regression models and Kaplan-Meier curves and newer techniques including win ratios. They then dip their toes into AI. A great overview by one of our leading clinical trialists.

1 year ago

34 minutes

Future Pulse Cardiology

Deep Dive into Lp(a) with Dr Steven Nissen Part 2 of 2

We would love to hear your thoughts on the episodes! This episode is a deep dive into Lipoprotein a with Dr Steven Nissen from the Cleveland Clinic. He and Dr Nero discuss the genetics of Lp(a), its pathophysiology, current treatment strategies and research into lowering Lp(a) levels. This is a fascinating conversation that also discusses the role of coronary inflammation in the work of Dr. Paul Ridker as well as the role of CT angiography in future clinical trials.

1 year ago

48 minutes

Future Pulse Cardiology

Lp(a): a basic clinical approach with Dr. Steven Nissen Part 1 of 2

We would love to hear your thoughts on the episodes! Dr Steven Nissen from the Cleveland Clinic discuses with Dr. Thomas Nero the basic clinical approach to Lp(a) with need for routine testing and a few simple case studies. In the second (longer podcast) they take a deep deep dive into Lp(a) genetic, pathophysiology and the current research trials.

1 year ago

11 minutes

Future Pulse Cardiology

Coronary Artery Disease in the Endurance Athlete with Dr Aaron Baggish

We would love to hear your thoughts on the episodes! Dr Thomas Nero speaks with Dr Aaron Baggish about coronary artery disease in the endurance athlete (and non-athlete as well!) They discuss cardiovascular testing in Masters athletes including ETT, coronary calcium scoring and CT angiography as well as risk factor identification, inflammation, physical & emotional stress and ongoing research. Dr Baggish is a Professor of Sports Cardiology at Université de Lausanne and founder...

1 year ago

41 minutes

Future Pulse Cardiology

Atrial Fibrillation and Clinical Trials with Dr John Mandrola

We would love to hear your thoughts on the episodes! Dr Mandrola discusses recent trail data with Dr. Thomas Nero including the results from Artesia, NOAH Afnet 6, Frail AF, Azalea and Oceanic-AF. They also discuss Left Atrial Appendage Occlusion and utility of wearable devices. Finally, a shout out to Dr. Andre Foy and his work on multi-morbidity and its role in clinical trial interpretation.

1 year ago

48 minutes

Future Pulse Cardiology

Coronary Calcium Score and CT Coronary Angiography with Dr. Mathew Budoff

We would love to hear your thoughts on the episodes! Dr. Thomas Nero speaks with Dr. Mathew Budoff about Coronary Calcium Scoring, CT Coronary Angiography and cardiovascular outcomes. The discussion goes beyond basic risk factor enhancement, highlighting its role to help evaluate disease progression, power future clinical trials and determine efficacy of therapy. Along the way, they discuss coronary inflammation, perivascular adipose tissue imaging and fat attenuation index (FAI) ...

1 year ago

24 minutes

Future Pulse Cardiology

Dr Elizabeth Ofili and The African American Heart Study

We would love to hear your thoughts on the episodes! Dr. Elizabeth Ofili discusses the African American Heart Study with Dr. Thomas Nero. They also discuss her work at the NIH and the African American Heart Failure Trial and the role of community based pragmatic clinical trials.

1 year ago

34 minutes

Future Pulse Cardiology

Anticoagulation, Thombin Generation and Factor XI inhibition in ACS and Atrial Fibrillation with Dr C. Michael Gibson

We would love to hear your thoughts on the episodes! Dr. Thomas Nero discusses current therapy with Factor X inhibitors, the new research with Factor XI inhibition and specifically the enrolling Milvexian clinical trials with Dr. C Micahel Gibson. In addition they discuss, the addition of these medications along wiht anti-platelet therapy, Lp(a) and other interesting current and future research in cardiovascular disease.

2 years ago

30 minutes

Future Pulse Cardiology

Diabetes and Cardiovascular Disease, SGLT2 inhibitors and GLP1 receptor agonists with Dr. Peter Toth

We would love to hear your thoughts on the episodes! Dr. Thomas Nero speaks with Dr Peter Toth about the dramatic change occuring in diabtetes management and its effect on cardiovascular disease. Starting with the biochemestry of diabetes and its effects at the cellular level, the discussion goes on to speak about the role SGLT2 inhibitors and GLP1 receptor agonists play in DM management as well as the future of diabetes care. (If you want to skip the excelllent, but quite deep di...

2 years ago

45 minutes

Future Pulse Cardiology

Lipids, Lipid Sub-fractionations and Inflammation, Putting It All Together with Dr Peter Toth

We would love to hear your thoughts on the episodes! Dr. Thomas Nero speaks with Dr. Peter Toth about the complex biology of lipids and atherosclerosis. In this episode Dr Toth dives into LDL goals, therapies for attenuating non-LDL risk, vascular biology and the where are research studies lead us in choosing therapies.

2 years ago

34 minutes

Future Pulse Cardiology

Inflammation and Coronary Artery Disease with Dr Paul Ridker

We would love to hear your thoughts on the episodes! Dr Paul Ridker discusses his paper on residual inflammatory risk that was recently published in the Lancet with Dr. Thomas Nero. He discusses the pathology of inflammation as part of atherosclerosis, utilization of hs-CRP in clinical trials and in daily practice as well as current therapeutic options and ongoing investigations.

2 years ago

40 minutes

Future Pulse Cardiology

Pragmatic Clinical Trials and EVOLVE-MI with Dr Christopher Cannon

We would love to hear your thoughts on the episodes! Dr Christopher Cannon discusses the potential of Pragmatic Clinical Trials in our research armamentarium with Dr. Thomas Nero. They review the EVOLVE-MI trial for Early use of Evolocumab after Myocardial Infarction in detail and highlight the potential for future research.

2 years ago

21 minutes

Future Pulse Cardiology

Spontaneous Coronary Artery Dissection (SCAD) with Dr. Sharonne Hayes Part 2

We would love to hear your thoughts on the episodes! Dr Sharoanne Hayes and Dr. Thomas Nero continue their discussion of SCAD focusing on genetics, trial design and the role of online registries as well as the holistic treatment of the SCAD patient. This is part two of two.

3 years ago

23 minutes

Future Pulse Cardiology

Spontaneous Coronary Artery Dissection (SCAD) with Dr. Sharonne Hayes Part 1

We would love to hear your thoughts on the episodes! Dr Sharonne Hayes of the May Clinic discusses SCAD with Dr. Thomas Nero. Initially focusing on the new treatment paradigms, their wide ranging discussion covers etiology, pathophysiology and potential future therapeutic options. Tis is the first of a two part podcast.

3 years ago

26 minutes

Future Pulse Cardiology

Evaluation of Coronary Inflammation with CT angiography and Fat Attenuation Indexing

We would love to hear your thoughts on the episodes! Dr. Nero discusses evaluation of coronary artery disease and coronary inflammaiton with Dr. Cheerag Shirodaria from the University of Oxford. Dr. Shirodaria along with Prof. Charalambos Antonidies at Caristo Diagnostics have developed a ground breaking technology that allows us to evaluate not just the severity of a coronary artery lesion, but also how inflamed it is and how likely it is to cause fatal and non-fatal myocardial i...

3 years ago

28 minutes

Future Pulse Cardiology

Legal Aspects of FDA approval and implications for clinical research

We would love to hear your thoughts on the episodes! Prof. Christine Coughlin of Wake Forest School of Law speaks with Dr. Thomas Nero on the FDA approval process, emergency use authorization, Right to Try Legislation and the implications for clinical research, diversity and health care equity. Prof. Coughlin holds positions in the College of Medicine as well as the Law school and in the Center for Bioethics. She has published extensively on the FDA approval process.

3 years ago

23 minutes

Future Pulse Cardiology

Coronary Artery Disease in the Athlete with Dr Paul Thompson

We would love to hear your thoughts on the episodes! Although exercise usually provides a cardiovascular benefit, there is some data that points to an increase in event rates in extreme endurance athletes. In this episode, Dr. Thomas Nero and Dr. Paul Thompson discuss the surprising findings regarding coronary calcium, cardiac troponins and atrial fibrillation in the endurance athlete and some thoughts about ideas to pursue in future research.

3 years ago

23 minutes

Future Pulse Cardiology

Statin Associated Muscle Symptoms with Dr Thomas Nero and Dr Paul Thompson

We would love to hear your thoughts on the episodes! Dr Nero and Dr Thomposn discuss Statin Associated Muscle Symptoms (SAMS) and the results of the STOMP and SAMSON trials. In addition, they discuss statins and athletic training, options for the statin intolerant patient and research regarding further investigation of the ranitadine receptor among other topics

3 years ago

22 minutes