I have received many requests for a masterclass on the gut microbiome, so I am excited to share one with you today. In our masterclass today, I discuss the microgenderome, explaining how the gut microbiome changes throughout our lives, during puberty, pregnancy, and perimenopause. I cover the key shifts in the microbiome that occur, especially as estrogen and progesterone fluctuate. I unpack the symptoms women experience that indicate their microbiome may be non-optimized, offering practical solutions, including lifestyle strategies, hormones, peptides, and targeted supplements. My goal is to do a solo episode every month. Please let me know which aspect you enjoyed the most, and what you would like to hear more about in my future monthly solo episodes. IN THIS EPISODE, YOU WILL LEARN: Why protein is critical in midlife, and how much of it you need to consume An easy way to incorporate the many different plant varieties you need to consume every week into your meals  Why fermented foods and prebiotics are essential for your gut health The benefits of giving your digestive system a 12-hour break each day How chronic stress affects your weight, hormones, and gut function The connection between sleep quality, gut health, and hormonal changes in midlife How to balance exercise intensity in midlife to support muscle maintenance and recovery Specific supplements to support gut integrity and energy production How hormone replacement therapy impacts the metabolism and microbial diversity  The value of improving your gut health to reduce menopausal symptoms Connect with Cynthia Thurlow   Follow on ⁠X⁠ ⁠Instagram⁠ ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠ Submit your questions to ⁠support@cynthiathurlow.com⁠

Today, we have another episode in a series of conversations with experts and highly vetted companies. In this episode, we feature CocoaVia, a brand of cocoa flavanol supplements made from a proprietary cocoa extract that aims to support cognition and heart health. I am delighted to welcome Dr. Amy Shah, who trained at Cornell, Harvard, and Columbia. Dr. Shah is a well-known expert on metabolic health and intermittent fasting. With a background in internal medicine, allergies, and immunology, she has helped many patients transform their health with cutting-edge nutritional and medical science.  In our conversation, we explore cocoa flavanols, explaining what they are, their benefits, and how they work mechanistically. We discuss how perimenopause and menopause can lead to endothelial dysfunction due to low sex hormones, and the effects of lifestyle factors like circadian rhythm alignment. Dr. Shah shares foods she finds particularly helpful for middle-aged women and reviews the research on cocoa flavanols. We also cover the impact of cocoa flavanols on health span, longevity, and brain health, including improvements in memory, word recall, and spatial reasoning, and Dr. Shah offers guidance on supporting the maturation and health of teens and young adults. Today’s conversation with Dr. Shah is practical and evidence-based. I also share how cocoa flavanols have helped my younger son’s focus and attention, and how my husband and I use these products in our daily lives. IN THIS EPISODE, YOU WILL LEARN: How cocoa flavanols support heart health, brain health, and longevity Why nitric oxide production matters for vascular flexibility, especially in perimenopause How circadian rhythm optimization improves energy, mood, and metabolic health Why introducing fiber and probiotic foods slowly may be necessary for gut adaptation How cocoa flavanols and other bioactives can enhance health span and lifespan The importance of selecting the right supplement quality and dose to prevent ineffectiveness or excess How cocoa flavanols can improve cognition, memory, and brain function over 8–12 weeks Why natural drinks (coffee, cocoa flavanols) are far better than energy drinks or caffeine for teens How combining core lifestyle habits with targeted bioactive compounds supports long-term health and longevity Connect with Cynthia Thurlow   Follow on X Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Amy Shah On her website CocoaVia

I am thrilled to have Gary Taubes back on the show today. (He was with me before on episode 137. Gary is an investigative science and health journalist whose work has been pivotal in catalyzing the low-carb keto movement. He has written many books, including his most recent, Rethinking Diabetes, and his articles are in many of the best anthologies. He has also received many science awards. Today's discussion is particularly significant, given the recent report from the American Diabetes Association revealing that the annual cost of diabetes in the United States reached a staggering $412.9 billion in 2022, with individuals diagnosed with diabetes now representing one in every four dollars spent on healthcare.  In our discussion today, we dive into the history of diabetes, pertinent statistics, the prevailing standard of care, and the transformative influence of insulin on diabetes management and reactive hypoglycemia. Gary provides insights into his reactions to GLP ones, the integration of medical and nutrition science into the medical field, and the influence of organizations such as the American Diabetes Association, AHA, USDA, and NIH. Our discussion also extends to the effects of pharmaceuticals, the shortcomings in our approach to diabetes management and existing models, and the challenge the low-carb community faces. Stay tuned for today's eye-opening conversation, where we shed light on the complexities surrounding diabetes care, explaining how simple lifestyle changes can tremendously improve quality of life. IN THIS EPISODE YOU WILL LEARN: Rethinking Diabetes is a groundbreaking exploration of diabetes diagnosis, management, and treatment Gary discusses the evolution of evidence-based medicine Why the traditional medical approach to treating diabetes is inadequate How the guidelines of the American Diabetes Association were based on outdated assumptions  How medical treatments compare with lifestyle changes for managing diabetes Controversies surrounding how the pharmaceutical industry has influenced the way medical associations have shaped their diabetes management policies How medical guidelines and dietary advice have evolved What constitutes a healthy diet? How patients often have trouble following diet recommendations, despite their best intentions Is obesity a hormonal disorder or caused by overeating?  Connect with Cynthia Thurlow Follow on X, ⁠Instagram⁠ & ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠ Submit your questions to support@cynthiathurlow.com Connect with Gary Taubes On his ⁠website⁠ X ⁠Facebook⁠ Previous Episode Mentioned ⁠Ep. 137 – High Blood Sugar Levels And Its Long-Term Damage with Gary Taubes⁠ Book Mentioned: Rethinking Diabetes: What Science Reveals About Diet, Insulin, and Successful Treatments is available from most bookstores or on ⁠Amazon⁠.

As a nurse practitioner, I feel a deep responsibility to my listeners and community to ensure that every guest I bring on shares accurate, evidence-based information. A few months ago, I decided to remove two podcasts from earlier this year to make way for an expert who could speak specifically and authoritatively on breast cancer health. So, I am honored to welcome Dr. Robin Roth today, better known as The Boobie Docs, on her popular breast health social media platform, where she shares information about breast cancer in a fun and educational way.  Dr. Roth is an associate professor of radiology, specializing in breast and abdominal imaging. She is also the host of The Girlfriend's Guide to Breast Cancer podcast, created to support those navigating a breast cancer diagnosis or caring for a loved one. In our discussion today, we dive into misinformation about breast health and breast imaging. We explore the importance of acknowledging disinformation on social media, risk factors for early breast cancer screening, significant and modifiable risk factors, and the effects of dense breast tissue. We examine breast imaging, exploring ultrasound and mammography, the differences between 2D and 3D mammograms (the gold standard), and when to use MRIs. We clarify why thermography and QT imaging are not the gold standard, and why we need to request different types of imaging modalities. We discuss the importance of screenings, challenges, including diagnoses like DCIS, personalized approaches to breast cancer screening, breast cancer staging, and issues with imaging after mastectomies and with implant placement. Dr. Roth also explains how 80% of breast biopsies end up being benign, how to manage anxiety and callbacks for mammograms, how to understand lab reports in plain language terms, and the benefits of supportive resources like cancerbesties.com. With her expertise and approachable style, Dr. Roth reminds us that proper information can make all the difference when it comes to breast health. You will not want to miss this conversation, especially during Breast Cancer Awareness Month. IN THIS EPISODE, YOU WILL LEARN: How online platforms fuel confusion around breast health and imaging Disinformation may influence breast cancer screening decisions Modifiable factors that can reduce or increase your risk of breast cancer Why dense breast tissue matters for imaging accuracy Ultrasounds, 2D and 3D mammograms, and MRIs  Thermography and QT imaging are not gold standards Why every individual DCIS diagnosis needs a personalized approach Breast cancer staging and how it guides treatment 80% of biopsies are benign, but still essential How to manage anxiety around callbacks and make sense of lab reports Connect with Cynthia Thurlow   Follow on X Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Robyn Roth On her website Social Media: @the boobie docs Preorder a copy of Everyone Has Boobies

Today, I am thrilled to reconnect with a friend and colleague, Dr. Mariza Snyder, to discuss her new book, The Perimenopause Revolution.  In our conversation, we explore some of the most pressing challenges around aging, including shame in a youth-obsessed culture, the lack of research on women’s health, and the physical toll of the aging process. We explain why the menstrual cycle should be considered a fifth vital sign, and what happens when metabolic health begins to decline in midlife, highlighting the value of apps and technology in empowering women to track their cycles. Dr. Mariza clarifies why biometrics, VO₂ Max, DEXA scans, and grip strength matter. She also shares her core pillars of metabolic health and the non-negotiables she believes make the most difference for women navigating the perimenopause-to-menopause transition. I truly enjoyed Dr. Mariza’s book, and I know it will be a powerful resource for women who want to take charge of their metabolic health during perimenopause and beyond. IN THIS EPISODE, YOU WILL LEARN: How hormonal shifts in midlife can alter energy, mood, and metabolism in unexpected ways Changes that ripple through sleep, stress, and cognition during perimenopause Why, in perimenopause, old diet and exercise strategies often stop working the way they used to  How cultural messages around aging fuel shame and confusion for women How DEXA scans reveal much more about your body composition than weighing yourself does What lab work can reveal about hidden risks  Why you should consider doing bone and muscle scans early in life The benefits of daily strength training for maintaining vitality and independence How regular movement stabilizes energy and glucose levels Why food choices become a critical foundation during midlife transitions Bio:  Dr. Mariza Snyder is a powerhouse advocate for midlife women, leveraging 17+ years as a practitioner, author, and speaker to spark a massive movement for women in perimenopause and beyond. With her top-rated Energized with Dr. Mariza podcast (13 million downloads) and a passionate social media audience with over 400K and 8 million monthly views, she’s a trusted guide—offering science-backed solutions for perimenopause and metabolic health. Her upcoming book, The Perimenopause Revolution (Hay House, October 2025), is the ultimate resource for women ready to take charge of their health and embrace perimenopause with resilience and confidence. Connect with Cynthia Thurlow   Follow on X Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Mariza Snyder On her website Energized with Dr. Mariza Podcast The Perimenopause Revolution

I’m honored to reconnect with Dr. Felice Gersh today! She is a multi-award-winning physician with dual board certification in OB-GYN and Integrative Medicine. We connected once before in Episode 221, where we spoke about PCOS and metabolic health. Today, Dr. Gersh joins me to dive into perimenopause and menopause. We discuss various issues surrounding the Women’s Health Initiative and talk about estrogen as a family of hormones, estrogen-mimicking chemicals, synthetic hormones, and oral contraceptives. We get into the importance of thyroid function, the pro-inflammatory state of a loss of estrogen in perimenopause and menopause, and the importance of nutrition and exercise for metabolism. We also speak about the lesser-known changes that occur in menopause, including changes in body odor, constipation, sarcopenia, osteoporosis, and vocal changes.  I intend to invite Dr. Gersh back again to discuss women and mitochondrial health, and then once again to talk about her latest book, Menopause: The Fifty Things You Need to Know.  Stay tuned to find out what menopause really is, and what it does to a woman’s metabolic system. IN THIS EPISODE YOU WILL LEARN: The Women’s Health Initiative study and its devastating effects Differences between synthetic and bioidentical hormones How chronic diseases of aging can be delayed when hormones are incorporated along with other lifestyle refinements What do hormones do? Why every immune cell in the body has receptors for vital hormones Menopause is not defined by a specific moment in time. Changes that occur physiologically during the perimenopause years How hormones can change the perimenopause paradigm  Why perimenopause translates into many sleep issues Phytoestrogens: nature’s gift to women Connect with Cynthia Thurlow Follow onX ⁠Instagram ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠  Connect with Dr. Felice Gersh On her website: ⁠Integrative Medical Group of Irvine⁠ Instagram⁠ All of Dr. Gersh’s books are available on ⁠Amazon⁠ ⁠Episode 221 on PCOS with Dr. Felice Gersh⁠

I am delighted to connect with a physician friend and colleague, Dr. Heather Hirsch, today. Dr. Hirsch is an entrepreneur and a board-certified internist by the American Board of Internal Medicine. She is also the Founder and CEO of Health by Heather Hirsch, and has a telemedicine practice offering best-in-class individualized care for perimenopause and menopause. In our discussion, we explore heavy menstrual cycles and the benefits of journaling and shared decision-making. We discuss common and frustrating causes of weight loss resistance in middle age, the power of strength training and adequate protein intake, and estrogen as a metabolic regulator that is intricately linked to many physical systems, including digestion. We also examine how educating clinicians on shifts in estrogen, progesterone, and testosterone during perimenopause could prevent countless ER visits, and we tackle concerns surrounding contraception and pregnancy prevention in perimenopause, a biopsychosocial approach to low libido, and the often-overlooked silent symptoms Dr. Hirsch often sees in perimenopause and beyond. Today’s conversation with Dr. Hirsch is truly invaluable. I highly recommend her Perimenopause Survival Guide, written by an internal medicine doctor extremely well-versed in perimenopause and menopause. IN THIS EPISODE, YOU WILL LEARN: How hormonal fluctuations disrupt the body and create confusion in perimenopause The benefits of journaling  How hormonal and lifestyle shifts disrupt metabolism, weight, and insulin sensitivity during perimenopause Why body composition changes matter more than your weight How declining estrogen affects insulin resistance, metabolism, and diabetes risk The value of shared decision-making  How hormones, medications, sleep, relationships, and past trauma can cause changes in libido  How siloed healthcare often leaves perimenopause symptoms misunderstood  How irregular ovulation increases pregnancy risk and why hormone therapy is not a contraceptive Connect with Cynthia Thurlow   Follow on X Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Heather Hirsch On her website YouTube  Social media: @Heather Hirsch MD

I am thrilled to connect with Anna Runkle today. Anna is known to more than a million subscribers across many platforms as the Crappy Childhood Fairy. For the last 30 years, she has shown people how to heal the symptoms of childhood trauma to live happier, freer, and more fulfilling lives.  In her work, Anna almost always noticed a haunting sense of disconnection from others as an adult symptom of childhood trauma. Today, she shares her story, and we dive into complex PTSD and shame, exploring the adverse childhood event study, dysregulation, and how neglect affects the brain and impacts emotional regulation, memory, and learning. We discuss disconnection as a trauma response, obstacles to isolation, and finding your voice in complex PTSD and menopause. Anna also shares her daily practice and explains how writing helps to regulate the nervous system.  You will love this invaluable conversation with Anna, also known as The Crappy Childhood Fairy, who is a fantastic resource for thousands, if not millions. IN THIS EPISODE, YOU WILL LEARN: How Crappy Childhood Fairy originated The differences between Complex PTSD and PTSD What does dysregulation look like? Unseen aspects of emotional dysregulation affect daily life Ways that childhood traumas can impact the brain How early trauma often leads to a chronic sense of disconnection Ways those with CPTSD can learn to cope with the stress of dealing with others and start connecting Anna shares her daily practice technique for emotional regulation Why the transition to menopause can be particularly hard for trauma survivors The importance of addressing trauma in healthcare and the need for better education and support for trauma survivors Connect with Cynthia Thurlow   Follow on X Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Anna Runkle On YouTube Anna’s book, Re-Regulated, is available on most online bookstores  Pre-order Anna’s new book, Connectability, and insert your receipt number to gain access to exclusive free bonuses.

Today, I am thrilled to reconnect with a previous guest, Dr. Mary Claire Haver.  Dr. Haver is a board-certified OBGYN, a certified menopause provider, and the founder of Mary Claire Wellness, a private medical practice focusing on women in midlife. Her best-selling book, the Galveston Diet, and her latest New York Times best-seller, The New Menopause, are fabulous resources for middle-aged women. In our discussion today, we dive into various aspects of perimenopause, looking at the associated challenges. We discuss factors accelerating ovarian aging, the role of contraception, mental health shifts, and the often delayed diagnosis of premature ovarian insufficiency. We examine the differences between hormone replacement therapy and oral contraceptives, discussing the importance of advocacy for women's health and the benefits of vaginal estrogen. We explore the disparity in federal funding for women's health research, the impact of the Women's Health Initiative, body composition changes, the estrabolome, the 30 Plant Challenge, and the advantages of HRT. Dr. Haver also talks about her preferred supplements.  I'm sure you will find this conversation a valuable resource that you will likely revisit several times. IN THIS EPISODE YOU WILL LEARN: Why perimenopause is so fraught with chaos Some of the factors that hasten ovarian aging How perimenopause causes significant changes in neurotransmitters, leading to cognitive changes The differences between HRT and oral contraceptives How estrogen loss during menopause affects vaginal tissue The benefits of vaginal estrogen for symptoms of menopause  How women's health research funding prioritizes reproduction over menopause and perimenopause How HRT can help with fat loss and muscle mass in postmenopausal women The emergence of eating-disordered behaviors in menopausal women Some of the lesser-known symptoms of menopause and ways to overcome them How HRT could impact the longevity and cognitive health of women Bio: Dr Mary Claire Haver Dr. Mary Claire Haver is a board-certified OB-GYN who has devoted her adult life to women's health. When she began to experience the changes of menopause and mid-life weight gain, she created her online program, The Galveston Diet, which currently has over 80,000 students. The Galveston Diet is the first and only nutrition program in the world created by a female OB-GYN, designed for women in menopause. As part of her ongoing research, she became certified in Culinary Medicine in 2019, specializing in medical nutrition. In 2021, Dr. Haver opened Mary Claire Wellness; the clinic was born out of repeated requests from the Galveston Diet students and Dr. Haver's social media followers for personal guidance.  Dr. Haver lives with her husband and two daughters in Galveston, Texas. She is the author of The Galveston Diet (Rodale; January 10th, 2023). Connect with Cynthia Thurlow   Follow on ⁠Twitter⁠, ⁠Instagram⁠ & ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠ Submit your questions to ⁠support@cynthiathurlow.com⁠ Connect with Dr. Mary Claire Haver On the⁠ Mary Claire Wellness website⁠ ⁠Instagram⁠ ⁠TikTok⁠ ⁠Facebook⁠ ⁠YouTube⁠ Books Mentioned Dr. Haver’s books, ⁠The Galveston Diet⁠ and ⁠The New Menopause ⁠ ⁠The Menopause Brain⁠ and the⁠ XX Brain⁠ by Lisa Mosconi Previous Episode Mentioned ⁠Ep. 308 Dr. Mary Claire Haver: Weight Gain in Middle Age, Perimenopause and Inflammation

Today, I am thrilled to connect with Dr. Elizabeth Yurth. Dr. Yurth is double board-certified, as a physician in physical medicine and rehabilitation in addition to anti-aging and regenerative medicine. With over 30 years of clinical experience, Dr. Yurth continues to lead the way in orthopedics, cellular and regenerative medicine, and the future of aging. In our conversation, we explore immunosenescence and its implications for longevity. We discuss the off-label utilization of medications, including low-dose naltrexone, rapamycin, and GLP-1s, and examine other types of peptides, growth hormone secretagogues, and thymic peptides. We speak about hormones and anabolics, highlighting the benefits of anabolics for the bone health of those with osteopenia and osteoporosis. Dr. Yurth also shares her favorite supplements and outlines the key elements for optimal brain health. This episode is the first of a series of conversations with Dr. Yurth. She will join us again to dive into cardiovascular disease and explore powerful ways to support healthy aging at the cellular level. IN THIS EPISODE, YOU WILL LEARN: Why the thymus gland shrinks with age and what that means for immunity How thymic peptides support immune health, healing, and recovery The role thymosin alpha-1 plays in modulating the immune system Why thymosin beta-4 must be cycled for safe healing support How IGF (Insulin-like Growth Factor) decline impacts muscles, joints, and the brain with aging How growth hormone secretagogues can safely raise IGF How BPC-157 (a gastric peptide) aids gut repair, musculoskeletal healing, and brain protection Why mitochondrial peptides matter for energy, recovery, and repair How anabolics support bone strength and recovery How creatine and choline support the brain and muscles Bio: Elizabeth Yurth, MD, ABPMR, ABAARM, FAARM, FAARFM, FSSRP, is Co-Founder and Chief Medical Officer of Boulder Longevity Institute, where she has been providing Tomorrow’s Medicine Today to her clients since 2006.  Dr. Yurth obtained her Medical Degree from the University of Southern California Keck School of Medicine, completed her residency at the University of California – Irvine, and her Fellowship in Sports and Spine Medicine from Stanford-affiliated Sports Orthopedics and Rehabilitation (SOAR) in Palo Alto, CA., along with her 30 years as a practicing orthopedist specializing in sports and spine medicine.  Dr. Yurth has made it her mission to learn and share the latest scientific research on how to truly heal the body at the cellular level. She is Fellowship trained in Anti-Aging, Regenerative, and Cellular Medicine. She has completed +500 hours of CME training focused on Longevity, Nutrition, Epigenetics, Bioidentical Hormone Replacement Therapy, Regenerative Peptide Treatments, and Regenerative Orthopedic Procedures.  Dr. Yurth continues to serve as a thought leader in Cellular Medicine, speaking at longevity events across the world and teaching others through her position as a founding faculty member for Seeds Scientific Research and Performance Institute (SSRP), which leads the way in connecting the latest research to clinical practice. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Elizabeth Yurth On her website Dr. Yurth on Facebook The Boulder Longevity Institute on Facebook Dr. Yurth on Instagram The Boulder Longevity Institute on Instagram

I am delighted to reconnect with Dr. Stephen Hussey today. He is a Chiropractor and Functional Medicine practitioner who guides his clients back to health using the latest research and health-attaining strategies.  In our conversation, we explore the challenge of chronic pain, discussing how it is assessed, experienced, and managed. We unpack the concepts of coherence and heart rate variability, highlighting the value of optimizing circadian rhythm for managing hormonal changes and pain in perimenopause. Dr. Hussey also shares his perspective on chiropractic care, the nervous system, fascia, and the role of trauma, metabolic health, and environmental factors in healing. Join us as we explore how to navigate chronic pain, support natural healing, and restore balance from the inside out. IN THIS EPISODE, YOU WILL LEARN: Why is pain so difficult to treat? How the Flexner Report influenced medical education and contributed to pharmaceutical-based care The breadth and scope of the opioid crisis, and why people become addicted How our bodies perceive pain  Why the fascia is so important, and its role in our physiological processes What is structured water? The link between cellular hydration, metabolic health, and the pain response How obesity and diabetes are directly associated with artificial light exposure How trauma rewires the brain and contributes to chronic pain Dr. Hussey explains the concept of coherence and its importance How pain changes during perimenopause and menopause  Bio: Stephen Hussey Dr. Stephen Hussey, MS, DC, is a Chiropractor and Functional Medicine practitioner. His story of personally healing heart disease using light and environmental health strategies has become an inspiration to many and a calling for change in healthcare. In addition to Chiropractic clinical practice, Dr. Hussey is a health consultant, speaker, and the author of three books on health: The Health Evolution, Understanding the Heart, and Pain Sense. Dr. Hussey guides clients from around the world back to health by using the latest research and health-attaining strategies. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Stephen Hussey On his website Social media:@drstephenhussey

I am delighted to have Jessie Inchauspé, the Glucose Goddess, joining me on the podcast today! Metabolic health is my passion! It is a huge area of focus in my work, and Jessie is truly a gift in the space! She is a rising star author and biochemist with a clear and accessible way of explaining the science behind glucose metabolism.  Jessie joins me today to discuss the impact of glucose metabolism and spikes. We dive into her background and how an accident created her pain-to-purpose story. We discuss the role of continuous glucose monitors and how glucose spikes impact our mitochondria, inflammation, and oxidative stress. We get into glycation and aging, how weight gain is a protective aspect of glucose spikes- or hyperglycemia, and the role of vinegar, movement, and fiber. We also talk about Jessie’s new book, her opinions on fasting, and so much more.  I loved interviewing Jessie! Her enthusiasm is contagious, and it is easy to understand why she is such a beloved author in the health and wellness space! IN THIS EPISODE YOU WILL LEARN: Jessie shares how an accident led her to where she is today. Wearing a continuous glucose monitor (CGM) changed everything for Jessie How Jessie developed her simple principles to stabilize glucose levels What is the purpose of glucose in the body? Glucose spikes and our mitochondria Vinegar hack for reducing side effects and symptoms of glucose spikes Being metabolically unhealthy impacts the aging process Benefits of having savory breakfasts and eating vegetables first with every meal Jessie’s book, The Glucose Goddess Method How gaining weight protects our bodies from the impact of glucose spikes Walking or moving after meals to balance blood sugar levels Why blood sugar so important Connect with Cynthia Thurlow Follow on X Instagram LinkedIn Check out Cynthia’s website Connect with Jessie Inchauspé On her website   Instagram Link for Jessie’s new book: Buy a copy of Jessie’s book, The Glucose Goddess Method.

Today, I am thrilled to be joined by Dr. Sarah Hill, an award-winning researcher, professor, and leading voice in the field of women’s hormones and brain health. She wrote This Is Your Brain on Birth Control and has also authored The Period Brain, which is due to be released this fall. In our conversation, Dr. Hill dispels the myths surrounding bioidentical hormones and shares her view on how women are not biologically disordered, but just ignored by science. We dive into research on how oral contraceptives affect the brain and how the pill creates a dysregulated stress response, particularly in women with histories of adverse childhood experiences. We also explore progesterone through the lens of an evolutionary biologist and neuro-endocrinologist, highlighting its role in supporting GABAergic tone, the key differences between synthetic progestins and natural progesterone, and research on PMS and PMDD, including practical ways to manage those issues. This helpful discussion with Dr. Sarah Hill is a must-listen for women at every stage of life. IN THIS EPISODE, YOU WILL LEARN: Why has science ignored women? How oral contraceptives affect the way women perceive the world How early-life trauma impacts the ability to manage stress in adulthood Often-overlooked benefits of progesterone The different ways estrogen and progesterone impact women’s ability to build muscle mass from resistance training The positive effects of the GABAergic system in the brain The problem with combined hormone therapy How progesterone gets ignored and villainized, even though it can help women experience better lives How the protective and anti-inflammatory properties of progesterone support brain health and enhance neuroplasticity What the research suggests for women experiencing severe PMS or PMDD Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Sarah Hill On her website Instagram Pre-order a copy of Dr. Hill’s new book, The Period Brain: The New Science of Why We PMS and How to Fix It, which will be on sale at the end of September. 

Today, I am thrilled to reconnect with my friend and colleague, Dave Asprey, for our third podcast together.  Dave is the founder of Bulletproof Coffee, the Bulletproof Diet, and the biohacking movement. He is a four-time New York Times best-selling author, and his latest book, Heavily Meditated, is a USA Today best-seller. As a leader in the longevity movement, Dave collaborates with medical professionals, researchers, and innovators to develop groundbreaking techniques and products that enhance mental and physical performance. In our discussion today, we explore what it means to be triggered, covering the five Fs, the role of ego and altered states, and the impact of social media, credentialism, and health bullying. We also discuss the importance of intuition, especially for women in perimenopause and menopause, highlighting that the ovaries contain the greatest concentration of mitochondria in the female body, the value of forgiveness, and the importance of finding peace in our lives. Dave also shares his breathwork “buckets bicep” practice and explains its effects on the dopamine receptors. I thoroughly enjoyed this inspiring conversation with Dave, and every woman navigating midlife transitions will benefit from the insights he shares in this episode. IN THIS EPISODE, YOU WILL LEARN: What it means to be triggered Dave explains the biological and neurological aspects of triggers The difference between managing triggers and turning them off at the source How fear, food, and reproduction drive automatic behavior The benefits of meditation  How criticism often triggers a deep-seated fear response  How credentialism and health bullying prevent people from trusting their intuition and personal experiences  The power of forgiveness to free energy and reduce emotional triggers. The value of intentional discomfort practices during perimenopause for recalibrating dopamine receptors The potential link between mitochondrial activity and the intuitive ability of women Bio:  Dave Asprey is the founder of Bulletproof Coffee, The Bulletproof Diet, and the biohacking movement. He is a four-time NYT bestselling author, the author of the recent USA Today Best-Seller, Heavily Meditated: The Fast Path to Remove Your Triggers, Dissolve Stress, and Activate Inner Peace, the CEO of Upgrade Labs, and hosts "The Human Upgrade" podcast. Dave pioneered online sales in the 1990s, co-founded an early data center company, and later transformed his own health by losing over 100 pounds and improving his cognitive function. This journey led him to create The Bulletproof Diet and coin "biohacking." Dave runs the 40 Years of Zen neurofeedback program, the Biohacking Conference, and a regenerative agriculture farm while investing in biohacking startups. As a leader in the longevity movement, Dave collaborates with medical professionals, researchers, and innovators to develop groundbreaking techniques and products that enhance mental and physical performance. Using science-backed methods, his mission is to help people upgrade their minds to a happier, more conscious state and optimize their bodies one cell at a time. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dave Asprey On his website Danger Coffee The Human Upgrade podcast Heavily Meditated: The Fast Path to Remove Your Triggers, Dissolve Stress, and Activate Inner Peace is available on Amazon.

Today, I am delighted to reconnect with two previous guests, Dr. Darren Candow. Dr. Candow is a distinguished professor and an internationally renowned researcher on creatine monohydrate, nutrition, and physical activity, whom I had the pleasure of speaking with on Episode 301, where we discussed creatine.  We are doing an AMA session today, delving into various themes surrounding creatine, from debunking outdated RDA recommendations to exploring the synergies between strength training and creatine efficacy. We examine the cognitive benefits of creatine, investigating its interactions with caffeine and its implications for bone health, hydration, anabolic resistance, and metabolic health.  You will find today's AMA session as enlightening and enriching as I did while recording it. IN THIS EPISODE YOU WILL LEARN: The safety and efficacy of creatine as a supplement How creatine increases muscle mass and reduces protein catabolism The benefits of combining creatine with protein  Is it better to take creatine before or after a workout? How creatine supplementation may improve brain performance and mental clarity Why exercise is essential for those who want to experience the benefits of creatine for maintaining their bone health The benefits of resistance-band workouts for post-menopausal women Are there any age-related limits for creatine supplementation? Bio: Dr. Darren Candow Dr. Darren Candow, PhD, CSEP-CEP, is Professor and Director of the Aging Muscle and Bone Health Laboratory in the Faculty of Kinesiology and Health Studies at the University of Regina, Canada. The overall objectives of Dr. Candow’s research program are to develop effective lifestyle interventions that incorporate nutrition (primarily creatine monohydrate) and physical activity (resistance training), with practical and clinical relevance for improving musculoskeletal aging and reducing the risk of falls and fractures. Dr. Candow has published over 120 peer-refereed journal manuscripts, supervised over 20 MSc and PhD students, and received research funding from the Canadian Institutes of Health Research, Canada Foundation for Innovation, the Saskatchewan Health Research Foundation, the National Institute of Health, and the Nutricia Research Foundation. In addition, Dr. Candow serves on the editorial review boards for the Journal of the International Society of Sports Nutrition, Nutrients, and Frontiers. Connect with Cynthia Thurlow Follow on X ⁠Instagram⁠ ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠ Submit your questions to ⁠support@cynthiathurlow.com⁠ Connect with Dr. Darren Candow On⁠ Instagram⁠ and X  Previous Episode Mentioned: ⁠Ep. 301 Creatine: The Best Supplement for Better Bones & Brain Health with Darren Candow, PhD, CSEP-CEP⁠

Today, I am honored to connect with Rachel Frankenthal, a board-certified physician assistant with a master's degree in public health, specializing in gynecologic oncology. Rachel is on the staff at UCLA Health, where she treats women with gynecologic cancers and women at high risk for uterine or ovarian cancer due to genetic mutations or a strong family history.  In our discussion, we unpack GYN oncology, covering the five GYN cancers, why ovarian cancer is the silent killer, and the labs and ultrasounds to help screen for ovarian cancer. We dive into genetics, including BRCA mutations and Lynch syndrome, appropriate genetic counseling, and what Rachel considers when dealing with younger patients still at peak fertility versus older patients. We explore the importance of HRT utilization for cancer previvors, the effects of pelvic radiation, vaginal and sexual health, and what thriving looks like after cancer. Rachel shares her stepwise approach to hot flashes, and we also discuss the importance of lifestyle, bone health, and specific research on the benefits of GLP-1s for women with ovarian and endometrial cancer.  This conversation is especially relevant as we are in GYN and Ovarian Cancer Awareness Month. I look forward to having Rachel back again, hopefully later this fall, to discuss the use of hormone replacement therapy with GYN oncology survivors. IN THIS EPISODE, YOU WILL LEARN: How the lack of effective screening makes ovarian cancer hard to detect due to  How BRCA and Lynch syndrome influence cancer risk and treatment choices The benefits of HRT for cancer previvors Risks that arise from surgical menopause without sufficient or properly dosed HRT Why less than 50% of eligible women actually receive hormone therapy How pelvic radiation impacts menopause, vaginal tissue, bladder, and GI health The support that is crucial for cancer survivors after pelvic radiation Lifestyle factors to improve cancer treatment outcomes   Rachel shares her stepwise approach to managing hot flashes  What GLP-1 research reveals about reducing ovarian cancer mortality and endometrial cancer risk Bio: Rachel Frankenthal Rachel Frankenthal is a board-certified and licensed Physician Associate and Menopause Society Certified Practitioner with a Master's in Public Health. She specializes in gynecologic oncology, treating women with gynecologic cancers as well as women at high risk for uterine or ovarian cancer due to genetic mutations. Rachel has a special passion for menopause and midlife women's healthcare. She developed the menopause clinic for gynecologic cancer survivors and previvors at UCLA and has played an integral role in developing the GYN cancer survivorship program, where she teaches the weekly yoga and meditation class. Rachel lectures at UCLA and across the country on the importance of comprehensive menopause care in cancer survivorship and has created a course on hormone therapy for gynecologic cancer survivors through the Heather Hirsch Academy. In addition to being a medical practitioner, Rachel is a certified yoga and Pilates instructor, a prior Broadway performer, and an advocate for integrative, holistic health. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Rachel Frankenthal On Instagram

Today, we have the first episode of a series of AMAs with McCall McPherson. McCall McPherson is the visionary behind Modern Thyroid Clinic, a thyroid-centered functional medicine practice in Austin, Texas. McCall is a physician assistant and thyroid expert. She is a recent TEDx speaker, a frequent guest on podcasts and summits, and the owner, host, and Chief Thyroid Hope Giver of the Thyroid Nations podcast.  Today, McCall joins me to dive into a range of listener questions, covering whether intermittent fasting damages the thyroid, the role of GLP-1s, constipation, split-dosing medication, adrenal health, ADHD, phentermine versus Glucophage versus GLP-1s, and how HRT affects thyroid medication. We also explore the impact of lipids on thyroid health and the role of nutrition, and we share our opinions on the Dutch test.  This invaluable AMA was made even more special by the flood of questions submitted by listeners. IN THIS EPISODE, YOU WILL LEARN: The benefits of adopting a nuanced approach to intermittent fasting  How Graves' disease and Hashimoto's differ in terms of fasting Why fasting is not advisable when taking GLP-1s Do thyroid medications cause constipation? Strategies for overcoming constipation and improving gut health McCall shares her rationale for splitting thyroid medication doses Will progesterone increase free T4 levels? The importance of rechecking thyroid labs after starting or adjusting HRT Foods to avoid and include in your diet for thyroid health Is the Dutch test worth using? Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with McCall McPherson Modern Thyroid Clinic  Modern Weight Loss On Instagram and TikTok Modern Thyroid and Wellness Podcast

Today, we have the next episode in our series of sponsored podcasts with highly vetted companies.  I am delighted to connect with Sarah Kennedy, the founder and CEO of Calocurb, a revolutionary product for weight management that became commercialized after 15 years and $30 million of research from the New Zealand government. Calocurb currently sells in five international markets and continues to grow rapidly through channels and geographies.  Sarah is a veterinarian by training and has held several senior executive positions in the agribusiness and food industries. In our conversation today, we explore the science behind Calocurb, the evolutionary mechanisms of satiety, and how Calocurb reduces caloric intake by 18%. We discuss endogenous GLP-1 drugs, highlighting how Calocurb’s mechanism of action differs, and examining current research on gender differences in GLP-1 secretion, including their impact on the menstrual cycle and intermittent fasting. Sarah also covers the four core tenets of Calocurb, shares upcoming research that excites her, and explains the key differences between Calocurb and other supplements, like berberine and chromium. This conversation is truly invaluable, so it's worth revisiting. I am excited about Calocurb’s potential to support a variety of needs, helping those looking to improve their hunger and satiety mechanisms, and assisting those taking GLP-1 medications who want to reduce their dosage and transition off GLP-1 medications without compromising the long-term results. IN THIS EPISODE, YOU WILL LEARN: How Calocurb began How Calocurb supports those on GLP-1s looking to lower their doses or taper off (in conjunction with their healthcare team) Sarah explains why Calocurb is very safe, and its four to six-hour mode of action.  The three primary use cases for Calocurb, and how it helps to reduce the side effects and costs associated with GLP-1 injections The importance of making lifestyle changes when transitioning off GLP-1 medications How Calocurb stimulates natural GLP-1 receptors, making it easier to manage food cravings during intermittent fasting Sarah shares how Calocurb helped her manage her love-hate relationship with food. How to take Calocurb for optimal effectiveness Sarah outlines Calocurb’s four core values.  How Calocurb differs from other supplements Foods that help to reinforce the satiety mechanism You can use code CYNTHIA10 for 10% off an order on ⁠calocurb.com⁠. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Sarah Kennedy You can use code CYNTHIA10 for 10% off an order on ⁠⁠calocurb.com⁠⁠. Research Articles: Gastrointestinal delivery of bitter hop extract reduces appetite and food cravings in healthy adult women undergoing acute fasting  New Zealand Bitter Hops Extract Reduces Hunger During a 24h Water  Only Fast Body weight reduction in women treated with tirzepatide by reproductive stage: a post hoc analysis from the SURMOUNT program   

Today, I am thrilled to reconnect with Dr. Kelly Caspersen, a urologist who empowers women to live their best love lives. She is a two-time author, with her latest being The Menopause Moment. In our conversation, we cover a wide range of topics, from navigating UTI purgatory and understanding the vaginal microbiome to how vaginal estrogen can dramatically reduce the risk of sepsis and death in the ICU. We unpack the evolving language of hormones- specifically progesterone, estrogen, and testosterone and we examine censorship and bias on social media, and the differences between prescribers and non-prescribers. We explore the effects of SSRIs on bone and brain health, changes in self-perception in middle age, and the effects of the baby boomer generation and the Women’s Health Initiative, exposing the medical gaslighting behind the use it or lose it narrative. We also offer practical options for women who cannot take hormones, and Dr. Kelly shares her go-to supplements and those she avoids. This conversation is one of my recent favorites. Dr. Kelly’s enthusiasm is contagious, and her straightforward approach makes complex topics clear, practical, and unforgettable. IN THIS EPISODE, YOU WILL LEARN: Why recurrent UTIs can feel like UTI purgatory How hormone terminology is evolving, and what that means for women in midlife The value of vaginal estrogen, and the potential it holds for saving women’s lives How the approaches of prescribers and non-prescribers differ How SSRIs can raise the risk of bone fractures  The brain health and self-perception shifts that often occur in midlife  Why the use it or lose it belief is misleading, and how it veers into medical gaslighting How the baby boomer generation and the Women’s Health Initiative still influence women’s healthcare today Some alternative options for women who cannot take hormones Dr. Kelly shares her preferred supplements and those she avoids Bio:  Dr. Kelly Casperson, MD Urologist • Author • Podcaster • Women's Health Thought Leader Dr. Kelly Casperson is a board-certified urologist, best-selling author, and top-ranked international podcaster empowering women to take control of their health, hormones, and sexuality. Known for blending science with storytelling, she transforms complex medical topics into relatable and actionable insights that help women live fully and fearlessly—especially in midlife. With her signature candor and evidence-based clarity, Dr. Casperson dismantles long-held myths around sex, menopause, and desire. Her acclaimed podcast, You Are Not Broken, has become a go-to resource for hundreds of thousands of women seeking real answers about their bodies and brains. Her groundbreaking work integrates urology, neuroscience, and mindset coaching to drive lasting change in intimacy, confidence, and overall well-being. As a keynote speaker and educator, Dr. Casperson challenges outdated norms in medicine while offering bold, science-backed solutions. She’s on a mission to build a world where women are educated, empowered, and no longer afraid of their own bodies. Whether she’s on stage, in a clinic, or behind the mic, Dr. Casperson is leading a health revolution—one smart, honest conversation at a time. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Kelly Casperson On her website On Instagram You Are Not Broken (Podcast) The Menopause Moment is available on Amazon and Barnes and Noble.

I am delighted to connect with Shanna Pearson today. She is the Founder and President of Expert ADHD Coaching, which is the most extensive ADHD coaching program of its kind in the world, providing one-on-one, action-based coaching for adults who are easily distracted and seeking personal, professional, and financial success. Shanna is also the author of Invisible ADHD.  In our discussion, we take a clear and practical look at what ADHD really is. We unpack the chemical changes that occur in the brain, highlighting the gender differences, and exploring why women have become the lost generation and why so many people get misdiagnosed. We also discuss common conditions that often accompany ADHD, the challenges of social conditioning, and share practical tools for addressing ADHD. Whether you have ADHD or you struggle with overwhelm, this discussion offers helpful insights and strategies that are sure to make a real difference. IN THIS EPISODE, YOU WILL LEARN: What ADHD truly is The brain biochemistry of those with ADHD How ADHD differs in men and women Why Shanna refers to women whose ADHD is undiagnosed until perimenopause or menopause as a lost generation    How ADHD in women often gets misdiagnosed How hormonal changes during perimenopause and menopause impact ADHD symptoms How societal expectations tend to exacerbate ADHD symptoms in women Strategies for managing ADHD Lifestyle factors that are essential for managing ADHD symptoms How her book, Invisible ADHD, can help anyone struggling with ADHD or overwhelm Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Shanna Pearson Expert ADHD Coaching   Purchase your copy of Invisible ADHD here, or on Amazon