In this episode, we unpack a landmark study that settles a decades-long debate over how synaptic vesicles release neurotransmitters—introducing the “kiss-shrink-run” pathway as the dominant mechanism in hippocampal synapses. Guided by host commentary, we explore how time-resolved cryo–electron tomography paired with millisecond optogenetic stimulation captured over 1,000 tomograms to reveal a rapid sequence: vesicles briefly “kiss” the membrane within 4 ms, form a ~4 nm fusion pore and “shrin...
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In this episode, we unpack a landmark study that settles a decades-long debate over how synaptic vesicles release neurotransmitters—introducing the “kiss-shrink-run” pathway as the dominant mechanism in hippocampal synapses. Guided by host commentary, we explore how time-resolved cryo–electron tomography paired with millisecond optogenetic stimulation captured over 1,000 tomograms to reveal a rapid sequence: vesicles briefly “kiss” the membrane within 4 ms, form a ~4 nm fusion pore and “shrin...
In this episode, we unpack a landmark study that settles a decades-long debate over how synaptic vesicles release neurotransmitters—introducing the “kiss-shrink-run” pathway as the dominant mechanism in hippocampal synapses. Guided by host commentary, we explore how time-resolved cryo–electron tomography paired with millisecond optogenetic stimulation captured over 1,000 tomograms to reveal a rapid sequence: vesicles briefly “kiss” the membrane within 4 ms, form a ~4 nm fusion pore and “shrin...
