COR2ED Medical Education: In this podcast, Prof. Andra H. James (Professor Emeritus of Obstetrics and Gynecology, Division Maternal Fetal Medicine, Duke University Hospital, Durham, North Carolina, US) and Dr Maria Elisa Mancuso (Senior Haematology Consultant at the Center for Thrombosis and Hemorrhagic Diseases of IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy) discuss various treatment options for severe postpartum haemorrhage (also called PPH). Experts discuss what causes PPH and how to determine the risk before and during labour with algorithms and other helpful tools. The discussion moves to when haematologic expertise is required and how collaboration can be optimized to provide the best care for patients. Furthermore, the experts share their learnings from clinical practice through discussion of specific patient cases, including patients with and without underlying bleeding disorders, as well as where haemostatic agents fit in the protocol.

What does thrombophilia testing mean for patients or their families? Do you know when and who to test for thrombophilia? In this podcast, experts Prof. Saskia Middeldorp and Prof. Jean Connors explore the diagnostic challenges for thrombophilia and which patients can benefit most from screening. In specific situations, testing can be crucial, but not always. Before testing, it is important to understand whether testing is needed and consider how it will provide support for decision making. ASH guidelines may be helpful. The experts discuss how these recommendations should be applied in general practice, as some caution is recommended.    Watch a video of the experts in conversation and download the full transcript on the COR2ED website: https://cor2ed.com/hemostasis-connect/programmes/thrombophilia-testing-part2/   Or go to the video on YouTube: https://youtu.be/uvXTtZHdT1k   Want to find out more? Listen to the other episode in the series:     Episode 1- Thrombophilia: Clinical overview and impact on patients  https://youtu.be/vy6r3JJLkG8?si=wXro9w7XYV6XS66U   https://cor2ed.com/hemostasis-connect/programmes/thrombophilia-part1/    The medical experts in this podcast express their own views, not those of COR2ED, supporters, or their institution. This podcast is supported by an Independent Medical Education Grant from Pentapharm    This educational podcast is developed by cor2ed.com

Innovation is the key to achieving success in the future, including recent scientific research to explore novel therapeutic options to improve the treatment of severe postpartum hemorrhage (PPH). If you're curious about the latest advancements in this field and how they can impact future treatment strategies for women who suffer from severe PPH, then listen to the fourth and final part of a podcast series on severe PPH. Experts will discuss the latest treatment advances and their perception of how the management of PPH will evolve in the future. Don't miss out on this opportunity to learn more about the latest scientific breakthroughs that can transform the lives of women suffering from PPH. Prefer to watch as well as listen? Watch a video of the experts in conversation and download the full transcript on the COR2ED website: https://cor2ed.com/obstetrics-gynecology-connect/programmes/severe-pph-treatment-developments/ Or go to the video on YouTube: https://www.youtube.com/watch?v=6HXtMNxgr1c The medical experts in this podcast express their own views, not those of COR2ED, supporters, or their institution. This podcast is supported by an Independent Medical Education Grant from Novo Nordisk. This educational podcast is developed by cor2ed.com.

Thrombophilia: Clinical overview and impact on patients What do you know about thrombophilia? Is it acquired or inherited, and what is the impact on patients? This is the first in a 2-part podcast series focusing on Thrombophilia. In this episode, you will hear from Prof. Cedric Hermans, who is the Head of the division of Hematology, the Hemostasis and Thrombosis Unit and Hemophilia center of the Saint-Luc University hospital in Brussels, Belgium, and Prof. Sabine Eichinger, who is the Head of the Coagulation Clinic at the Medical University of Vienna, Austria. The experts discuss the main causes and symptoms of thrombophilia and the potential implications for the patient. They share their knowledge on the differences between acquired or inherited thrombophilia and discuss which specific patients can benefit from screening to prevent overtreatment or undertreatment.  Prefer to watch as well as listen? Watch a video of the experts in conversation and download the full transcript on the COR2ED website: https://cor2ed.com/hemostasis-connect/programmes/thrombophilia-podcast-series-part-1/ Or go to the video on YouTube: https://youtu.be/vy6r3JJLkG8 The medical experts in this podcast are expressing their own views and not those of COR2ED, supporters, or their institution. This podcast is supported by an Independent Medical Education Grant from Pentapharm. This educational podcast is developed by cor2ed.com.

Gene therapy and gene-modified cell therapies have a great potential for rare diseases to either help patients to cure their disease or improve their lives. Did you know that gene therapy will probably become a major treatment option for many rare diseases in the near future? Listen as expert hematologists delve into this topic and take hemophilia as a practical example. Join Prof. Cédric Hermans (Head of the Division of Haematology, the Hemostasis and Thrombosis Unit and the Hemophilia Center of the Saint-Luc University Hospital in Brussels, Belgium) and Prof. Miguel Escobar (Professor of Medicine and Pediatrics, University of Texas Health Science Center at Houston-McGovern Medical School and University of Texas M.D. Anderson Cancer Center Medical Director, Gulf States Hemophilia & Thrombophilia Center Houston, USA) as they engage in a conversation about the potential of gene and gene-modified cell therapies in rare diseases, and how early gene therapies have been implemented as a treatment approach for rare diseases, such as leber congenital amaurosis, spinal muscular atrophy, beta-thalassemia, adrenoleukodystrophy, and hemophilia. The experts explore hemophilia as an example of how gene therapy has become a reality within rare diseases. They discuss why we need gene therapy for rare disease, what gene therapy and gene modified cell therapy is, and how this has become a reality in hemophilia, and look to the future of gene therapy for rare diseases. Finally they reflect on the importance of a multidisciplinary approach. - Access information on the programme, the clinical takeaways, the flashcard and the transcript here https://cor2ed.com/hemostasis-connect/programmes/gene-therapy-rare-diseases/ Find out about the experts Prof Cedric Hermans and Prof. Miguel Escobar.  The medical experts in this podcast are expressing their own views and not those of COR2ED, supporters, or their institution. This podcast is supported by an Independent Medical Education Grant from The American Society of Gene + Cell Therapy and Pfizer.

Thrombotic risk is a constant threat in perioperative patients, but it has decreased with the evolution of surgical technology.  Do you know how to minimise the risk of thrombosis in your surgical patients?  Learn from expert colleagues from the University of Basel, Switzerland: Prof. Dimitrios Tsakiris (hematologist) and Prof. Daniel Bolliger (anesthesiologist).  In this podcast episode the two experts discuss the pathophysiology of perioperative thrombosis, how to apply perioperative thromboprophylaxis and consider special considerations such as the use of aspirin following orthopedic surgery, when to monitor anticoagulants and the use of inferior vena cava (IVC) filters as thromboprophylaxis.  This is the final episode podcast in a four-part series on thrombosis in various clinical conditions.

Extended anticoagulation beyond the initial 3 months is indicated for all types of VTE, except in surgery-or trauma-VTE or in patients at high risk of bleeding. Are you up to date on the latest treatment options for VTE and their duration?  Expert haematologists Prof. Dimitrios Tsakiris (University of Basel, Switzerland) and Prof. Jerzy Windyga (Institute of Haematology and Transfusion Medicine, Warsaw, Poland) engage in a discussion on this important topic. This is the third podcast in a four-part series on thrombosis in various clinical conditions. In this podcast we focus on anti-thrombotic treatment for VTE and how long optimal treatment should be.

In this podcast, Prof. Andra H. James (Professor Emeritus of Obstetrics and Gynecology, Division Maternal Fetal Medicine, Duke University Hospital, Durham, North Carolina, US) and Dr Maria Elisa Mancuso (Senior Haematology Consultant at the Center for Thrombosis and Hemorrhagic Diseases of IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy) discuss various treatment options for severe postpartum haemorrhage (also called PPH). Experts discuss what causes PPH and how to determine the risk before and during labour with algorithms and other helpful tools. The discussion moves to when haematologic expertise is required and how collaboration can be optimized to provide the best care for patients. Furthermore, the experts share their learnings from clinical practice through discussion of specific patient cases, including patients with and without underlying bleeding disorders, as well as where haemostatic agents fit in the protocol.

In this podcast episode, Prof Dimitrios Tsakiris (Haematologist, Basel University, Switzerland) and Dr Lars Asmis (Haematologist, University of Zurich, Switzerland) discuss the association between thrombosis and cancer.  Experts discuss how different tumours affect the risk for thrombosis in patients and genetic disorders such as thrombophilia. They cover multiple scores (Khorana, Vienna, PROTECHT and Pabinger) that might help to categorise thrombosis risk in oncology patients. The discussion moves to how cancer patients with thrombosis should be treated and the duration of treatment of low molecular weight heparins and direct oral anticoagulants (DOACs), with reference to the CLOT study and recent guidelines. In addition, they discuss whether there should be a different approach with hospital in- and out-patients  Finally, both experts discuss anticoagulation and oncocardiology and the higher incidences of atrial fibrillation reported in cancer patients.

Dr Homa K. Ahmadzia (Maternal-Fetal Medicine specialist and Assistant Professor in the Department of Obstetrics and Gynecology at George Washington University hospital, USA) and Dr Jarmila A. Zdanowicz (Senior Consultant in Obstetrics and Gynecology, Clinical Head Maternity Unit, Fellow in Feto-Maternal Medicine, Department of Obstetrics and Gynecology, Bern University Hospital, Switzerland), discuss severe postpartum haemorrhage (also called PPH). To set the scene, they explain important definitions and real-world incidence, in particular in higher resourced and less resourced countries. What is the difference between non-severe and severe PPH? What specialities are involved? And what are the consequences when PPH is not treated correctly? Additionally, Dr Ahmadzia and Dr Zdanowicz consider who is at risk, what measures can be used to diagnose, and the importance of prevention as well as treatment.

In this podcast, Dr Sarah O’Brien and Dr Homa Ahmadzia discuss gynaecological considerations in women and girls who have an underlying bleeding disorder. The experts discuss the two sides of the coin regarding women with bleeding disorders: women may have uterine bleeding due to their bleeding disorder, however there can also be gynaecological causes for the heavy bleeding. Dr O’Brien and Dr Ahmadzia also review the signs and symptoms of bleeding disorders, as well as gynaecological causes for uterine bleeding including endometriosis, adenomyosis fibroids, and uterine anomalies. They discuss treatment as well as specific situations such as gynaecological surgery, and the importance of collaboration with other specialists. Dr Sarah O’Brien is a Paediatric Haematologist at Nationwide Children’s Hospital in Columbus, OH, USA and Dr Homa Ahmadzia is a Maternal and Foetal Medicine Physician at George Washington University, DC, USA

In this podcast, Haematologists Dr Michelle Lavin and Dr Roseline d’Oiron discuss the importance of recognising and correcting iron deficiency in women and girls with bleeding disorders. Iron deficiency occurs very frequently in this population, but challenges with definitions, lab tests and reference ranges can make it hard to accurately detect. The experts discuss how to diagnose and correct iron deficiency, and how to monitor patients. They also share some practical dos and don’ts and describe how iron deficiency is easy to treat, while making an immense difference on the quality of life of patients.   Dr Michelle Lavin is a Haematologist at the National Coagulation Centre, St James's Hospital, Dublin, Ireland and Dr Roseline d’Oiron is a Haematologist at the Reference Centre for Haemophilia and RBD, Bicêtre Hospital AP-HP and University of Paris-Saclay, Paris, France.

Haematologists Prof. Ana Boban and Dr Jonathan Roberts discuss how the type of von Willebrand disease (VWD) impacts the treatment. In this podcast, aimed at healthcare professionals outside of haematology, the experts summarise the key treatment options for VWD and discuss how they make treatment decisions on a daily basis, including treatments they tend to avoid in certain types of the disease. They also consider management in some specific clinical scenarios, including a spontaneous bleed, surgery, and heavy menstrual bleeding.    Prof. Ana Boban is Head of the Haemophilia Centre, University Hospital Centre Zagreb, Croatia, and Dr Jonathan Roberts is Associate Medical Director, Associate Research Director, Bleeding and Clotting Disorders Institute, Peoria, IL, USA.

In this podcast, Obstetrician and Gynaecologist Prof. Rezan Abdul-Kadir and Advanced Nurse Practicioner Debra Pollard discuss the impact of bleeding disorders before, during and after pregnancy and delivery. Their share their views on what healthcare providers should take into consideration when a woman with a bleeding disorder wants to have children and becomes pregnant, including potential risks and expectations of the pregnancy. Support for women and babies is discussed, including the importance of multidisciplinary care. The experts also explore their experience during and after delivery, and what to be aware of in the post-partum period. Prof Rezan Abdul-Kadir is an Obstetrician and Gynaecologist at the Royal Free Hospital in London and Debra Pollard is an Advanced Nurse Practicioner at the Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free Hospital in London, UK.

In this podcast, Prof. Cedric Hermans and Prof. Jerzy Windyga discuss their perspectives on the changing paradigms of haemophilia care. They share their past experience and their views on the current situation in Europe, based on results from a recent survey and published in Therapeutic Advances in Hematology. The aim of this survey was to determine whether the paradigms of haemophilia care in Europe have changed with the introduction of novel treatment options. In the podcast, the two experts not only discuss the past and present of haemophilia care, but also share their visions on the future. Prof. Hermans is the Head of the Division of Haematology at the Cliniques Universitaires of Saint-Luc in Brussels, Belgium. Prof. Windyga is the Head of the Department of Haemostasis Disorders and Internal Medicine at the Institute of Haematology and Transfusion Medicine in Warsaw, Poland. Both experts are members of HEMOSTASIS CONNECT’s European Collaborative Haemophilia Network.

COR2ED Medical Education: Prof. Karin Fijnvandraat, Professor of Paediatric Haematology at the University of Amsterdam in the Netherlands and Dr. Maria Elisa Mancuso, Senior Consultant in Haematology at IRCCS Humanitas Research Hospital in Milan, Italy, have an interesting discussion about prophylaxis in children with haemophilia. Along with five other members of the European Collaborative Haemophilia Network, Prof. Fijnvandraat and Dr. Mancuso recently published a white paper on prophylaxis in children in an evolving treatment landscape, in the journal Haemophilia. In this podcast episode the two experts discuss when they start prophylaxis in young children, how they choose between plasma-derived and recombinant products and how they select the right treatment regimen, as well as practical aspects of starting prophylaxis, including the importance of involving parents in the decision-making process. 

In this third episode of the podcast series Women and Girls Bleed Too, Advanced Nurse Practitioner Debra Pollard (Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free Hospital, London, UK) is joined by Haematologist Dr. Michelle Lavin (RCSI and National Coagulation Centre, St James’ Hospital, Dublin, Ireland). They talk about the impact a bleeding disorder can have on the lives on women and girls and how these patients can and should be supported in first- and second-line care. When thinking about management, many healthcare providers will first consider medical treatment. Dr. Lavin gives a brief overview of the first-line treatment options for women and girls with bleeding symptoms. However, the speakers stress that the management of these patients goes beyond medical treatment options alone. They provide practical tips and recommendations for first-line healthcare professionals when they treat a patient with a bleeding disorder. As many bleeding disorders are hereditary diseases, a diagnosis not only has impact on the patient, but on their family as well. A bleeding disorder also impacts family planning, pregnancy, and quality of life. Medical and psychological support is essential throughout life. Finally, Michelle Lavin and Debra Pollard discuss some important topics for first-line healthcare providers to be aware of when they have a woman with a bleeding disorder in their practice, including the impact of a bleeding disorder on any medical invention, such as surgery, dental procedures or infertility treatment, but also on the use of pain medication.

In this second episode of the podcast series Women and Girls Bleed Too, Haematologist Dr. Roseline d’Oiron (Reference Centre for Haemophilia and RBD, Bicêtre Hospital AP-HP and University of Paris-Saclay in France) and Obstetrician/Gynaecologist Prof. Rezan Abdul-Kadir (The Royal Free Foundation Hospital in London, UK) discuss how to identify women and girls who are likely to have a bleeding disorder. Prof. Abdul-Kadir addresses the steps she takes when she suspects a potential bleeding disorder in one of her patients. Dr. d’Oiron confirms it is key to get a clear understanding of the personal bleeding history and family history. There are several screening tools available to help assess the patient’s signs and symptoms. The experts discuss when a patient should be referred to a Haematologist, it is important to know that Haematologists are easily accessible for referral when in doubt. Finally, Dr. d’Oiron and Prof. Abdul-Kadir address the types of testing that should and should not be done in first line. It turns out there are many misconceptions about laboratory testing for bleeding disorders. For example, contrary to common belief a normal aPTT and PT does not exclude a bleeding disorder. Furthermore, referring to a Haematologist for testing does not mean the patient should remain untreated. Starting basic treatment is crucial to limit the bleeding and address any iron deficiency as quickly as possible.

In this first episode of the podcast series Bleeding Disorders in Women and Girls: Women & Girls Bleed Too, Dr. Michelle Lavin (Haematologist at the National Coagulation Centre, St James’ Hospital, Dublin, Ireland) and Dr. Sarah O’Brien (Paediatric Haematologist at the Nationwide Children’s Hospital, Columbus, OH, USA) discuss how bleeding disorders occur in women and girls: Women & Girls Bleed Too. In clinical practice, sometimes girls can be forgotten about as bleeding disorders are more associated with males. Dr. Lavin and Dr. O’Brien discuss the signs and symptoms of bleeding disorders and their impact on the quality of life of young girls, adolescents and adult women. Furthermore, they address how diagnosis may be easier in adults than in children, given the longer history of bleeding challenges. The experts also explore potential taboos in discussing these signs and symptoms with patients, considering intercultural differences and gender taboos, and the importance of normalising the conversation amongst healthcare professionals. Finally, Dr. Lavin and Dr. O’Brien provide guidance on the next steps first-line healthcare providers should take when they see a patient with abnormal bleeding, including treatment initiation to limit the bleeding and address iron deficiency and referral to a haematologist for further assessment.