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Checkpoint NOW
Afreen Shariff
32 episodes
5 days ago
All you need to know about the latest evidence based practice in the diagnosis and management of immune related toxicities from cancer therapies straight from the experts in the field.
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Medicine
Health & Fitness
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All content for Checkpoint NOW is the property of Afreen Shariff and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
All you need to know about the latest evidence based practice in the diagnosis and management of immune related toxicities from cancer therapies straight from the experts in the field.
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Medicine
Health & Fitness
Episodes (20/32)
Checkpoint NOW
Episode 31: Journal Club: To re-challenge or not in refractory pneumonitis

Host Dr. Afreen Shariff is joined by guest host Dr. Pankti Reid, Rheumatologist, University of Chicago where they discuss the topic "To re-challenge or not in refractory pneumonitis" with expert Pulmonologist Dr. Kevin Ho (The Ohio State University) and Medical Oncologist Dr. Aliyah Pabani (Johns Hopkins Medicine) who discuss some key articles.


Articles: https://pmc.ncbi.nlm.nih.gov/articles/PMC7797270/Balaji, et al, J Immunother Cancer. 2021

https://pubmed.ncbi.nlm.nih.gov/33568350/ Beattie, et al, J Immunother Cancer. 2021

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5 months ago
37 minutes 39 seconds

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Episode 30: Fatigue and Cancer- Symptom of cancer or a sign of a toxicity?

Join hosts Dr. Afreen Shariff (Duke, Citrus Oncology) and Dr. Pauline Funchain (Stanford) as they discuss a common yet challenging topic of fatigue in a cancer patient with guest expert, medical oncologist, palliative care expert, ASCO guideline lead Dr. Eric Roeland (Oregon Health).

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5 months ago
41 minutes 53 seconds

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Episode 29: Balancing conversations about toxicities

Join hosts Drs. Afreen Shariff and Pauline Funchain as they discuss with health care communications expert Dr. Timothy Gilligan from Cleveland Clinic about the delicate balance between the fear of toxicities and providing meaningful information for patients and caregivers so they feel empowered and engaged.

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11 months ago
53 minutes 41 seconds

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Episode 28: Alliance Clinical Trial for Immune Mediated toxicities

Join hosts Dr. Afreen Shariff and Dr. Pauline Funchain as they discuss with Dr. David Kozono, a radiation oncologist at Dana Farber Cancer Institute and the chair of the ALLIANCE clinical trial to set up a national Biorepository to Study Immunotherapy Side Effects.

https://www.allianceforclinicaltrialsinoncology.org/main/public/standard.xhtml?path=/Public/News-A151804-Oct2020

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1 year ago
21 minutes 22 seconds

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Episode 27: ASPirE- The International Alliance for Support and Prevention of immune related Events

Join the Executive Committee of ASPirE- Dr. Afreen Shariff, Dr. Pauline Funchain, Dr. Kerry Reynolds, Dr. Alexa Meara and Dr. Elad Sharon as they discuss the new international Initiative that brings clinicians, educators, researchers and patients together to inform science and clinical innovation in irAEs.

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1 year ago
52 minutes 24 seconds

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Episode 26: Cancer treatments and the Heart

Learn about the effect of cancer treatments on the heart. Who needs to see a cardiologist before, during and after cancer treatment- the When and Why with oncologist Dr. Susan Dent and cardio oncologist Dr. Robert Copeland-Halperin.

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1 year ago
45 minutes 12 seconds

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Episode 25: Adrenal Insufficiency- What patients need to know.

Join Dr. Afreen Shariff and Dr. Pauline Funchain as they break down Adrenal Insufficiency from cancer treatments in simple terms for patients, caregivers and care teams.

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1 year ago
46 minutes 31 seconds

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Episode 24: Costs of adverse events in Renal Cell Carcinoma

Learn from the experts about the costs associated with irAEs in patients treated for Renal Cell Carcinoma. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts- medical Oncologists Dr. Daniel Geynisman and Dr. Bradley McGregor, MD for an informative and high yield discussion regarding real and hidden costs of adverse events and how this impacts patients. 

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2 years ago
25 minutes 19 seconds

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Episode 23: Emotional impact of side effects on patients and caregivers
Join host Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Psychologist, Dr. Rebecca Shelby about the emotional impacts like stress, depression, and anxiety associated with side effects from cancer treatments.
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2 years ago
30 minutes 39 seconds

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Episode 22: Germline Variants, Toxicities and ICI
Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts from Dana Farber Cancer Institute, GU Oncologist Dr. Toni Choueiri and Quantitative Geneticist Dr. Sasha Gusev as they discuss Germline variants associated with immune checkpoint blockade and associated irAEs.
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2 years ago
18 minutes 59 seconds

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Episode 21: Thyroid disease in cancer patients. What you need to know as a patient!
Hosts: Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts and thyroidologists Dr. Trevor Angell and Dr. Anupam Kotwal as they discuss information regarding thyroid disease in cancer patients for patients and caregivers.
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2 years ago
14 minutes 46 seconds

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Episode 20: Patient experience, advocacy and immune toxicities
Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with Dena Battle from KCCure- an evidence based, patient driven advocacy organization. Dena shares her deep insight on patient, caregiver experiences around toxicity management and how we can learn from each other to improve patient outcomes.
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3 years ago
33 minutes 11 seconds

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Episode 19: ICI use in Special Populations
Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they talk to expert oncologists Dr. Sharon and Dr. Nagash to learn about Immune Checkpoint Inhibitors in special populations. Dr. Sharon is an accomplished Oncologist at the National Cancer Institute. He co-Directs immunotherapy trials at the Cancer Therapy Evaluation Program (also known as CTEP) and serves as an attending physician in NCI's Developmental Therapeutics Clinic. As part of his work in immunotherapy drug development, he has made a major effort to advance the understanding of immune-related adverse events, including the establishment of the Alliance-NIH irAE Biorepository. Dr. Naqash, is an Oncologist with a focus on Early phase clinical trials, drug development and biomarkers in Immunotherapy. He is currently an Assistant professor of Medicine at the Oklahoma Health Stephenson Cancer Center.
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3 years ago
40 minutes 34 seconds

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Episode 18: Immune mediated neurological toxicities (Part 2)
Learn from the experts about the latest in immune mediated neurological toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts- medical Oncologist Dr. Kerry Reynolds, and expert neurologists Drs. Amanda Guidon and Leeann Burton from Massachusetts General Hospital for an informative and high yield discussion.
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3 years ago
39 minutes 10 seconds

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Episode 17: Autoimmune Type 1 Diabetes: Challenge for our patients and clinicians

Learn from the experts about the clinical diagnosis and multidisciplinary management of autoimmune Type 1 Diabetes. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts and endocrinologists Dr. Ole-Petter Hamnvik and Dr. Le Min from Brigham and Women's Hospital Harvard Medical School and Dana Farber Cancer Institute for an informative and high yield discussion. 

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3 years ago
33 minutes 54 seconds

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Episode 16: Learning about Immune mediated Adverse events from a trainees persepective

Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with resident physicians Dr. Harsh Patolia, Dr. Nathan Hirshman and Dr. Michelle Ferriera who share their experience and tips for fellow residents in training on managing immune mediated adverse events.

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4 years ago
14 minutes 58 seconds

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Episode 15: Neuro-toxicities from Immune checkpoint Blockade: Rare and complex (Part 1)

Learn from the experts about immune mediated neurological toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Neurologist Dr. Andrew Mammen. 

Andrew Mammen, M.D., Ph.D., joined NIAMS as Muscle Disease Unit Leader in the Laboratory of Muscle Stem Cells and Gene Regulation in 2014. He obtained his medical degree and Ph.D. in neuroscience at Johns Hopkins in 2000, where he subsequently completed his medicine internship, neurology residency, and neuromuscular fellowship. Prior to his appointment at NIH, he was Associate Professor of Neurology and Medicine at the Johns Hopkins University School of Medicine. He co-founded the Johns Hopkins Myositis Center in 2007, where he continues to see myositis patients as an adjunct faculty member. Dr. Mammen and his colleagues at Hopkins discovered a novel form of autoimmune myopathy associated with statin use and autoantibodies recognizing HMG-CoA reductase, the pharmacologic target of statins. In addition to clinical studies involving myositis patients, his current laboratory research interests include defining pathogenic mechanisms in the various forms of autoimmune myopathy and understanding the role of myositis autoantigens in muscle regeneration.

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4 years ago
15 minutes 23 seconds

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Episode 14: Immune Mediated Liver Injury

Learn from the experts about the latest in Immune Mediated Liver Toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Transplant Hepatologist Dr. Lindsay King.

Dr. King is a Hepatologist, Assistant Professor of Medicine at Duke University School of Medicine.

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4 years ago
27 minutes 16 seconds

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Episode 13: Skin Toxicities from Immune Checkpoint Inhibitors (PART 2): Common and perplexing

Hosts: Learn from the experts about the latest in Onco- Dermatology and Immune skin Mediated toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Dermatologist Dr. Adela Rambi Cordones. Dr. Cordones is a Dermatologist, Associate Professor of Dermatology at Duke University School of Medicine. She leads the Immunodermatology Clinic at Duke and is clinician investigator with an expertise in Autoimmune Skin Disease and Cutaneous Drug reactions. 

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4 years ago
17 minutes 9 seconds

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Episode 12: Skin Toxicities from Immune Checkpoint Inhibitors (PART 1): Common and perplexing

Learn from the experts about the latest in Onco- Dermatology and Immune skin Mediated toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Dermatologist Dr. Meenal Kheterpal. Dr. Kheterpal is a Dermatologist, Assistant Professor of Dermatology at Duke University School of Medicine. She also directs clinical research in Melanoma and Non - Melanoma Skin Cancer at Duke Dermatology.

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4 years ago
17 minutes 59 seconds

Checkpoint NOW
All you need to know about the latest evidence based practice in the diagnosis and management of immune related toxicities from cancer therapies straight from the experts in the field.