Customer support platforms lacked adequate solutions for B2B companies - until Pylon entered the scene. We sat down with Pylon cofounders Marty Kausas, Advith Chelikani, and Robert Eng to discuss why they went into B2B, how they plan to beat huge competitors, and why they still live together in a windowless apartment and work 9-9-6 hours despite having raised tens of millions.

In 2025, we saw the first glimpses of true AI agents. In 2026, every company will be rushing to get them into production, and they’ll need companies like Keycard to manage fleets of agents. In this conversation, a16z Partner Joel de la Garza sits down with Keycard Cofounder and CEO Ian Livingstone to discuss the continuum from copilots to agents, the security realities of tool-calling, why enterprises will adopt before consumers, and how to control your agents.

AI coding has emerged as a major market for AI: one that’s already rewriting how software gets built. a16z Infra Partners Yoko Li and Guido Appenzeller break down how “agents with environments” are changing the dev loop; why repos and PRs may need new abstractions; and where ROI is showing up first (like legacy code migration).

What if the hardest part of building a company isn’t the product, but knowing exactly who it’s for? In this episode, a16z General Partner Martin Casado sits down with Abhishek Agrawal, Cofounder and CEO of Material Security, to discuss how an ideal customer profile is discovered, how to manage any kind of customer, and how frothy markets can distort real signal.

AI is changing the security game. a16z partner Joel de la Garza talks with Kevin Tian, cofounder & CEO of Doppel Security, about the rise of social engineering attacks, why LLMs are now core to defense, and how Doppel is automating detection, takedowns, and even training simulations. They also discuss deepfake fraud, building at the edge of new model releases, and why the hardest problem today is engineering time—not ideas.

In this conversation, a16z General Partner Martin Casado and Partner Yoko Li sit down with scientist and Lytro founder Ren Ng along with Phota Labs cofounders Cecilia Zhang and Zhihao “Zach” Xia to explore the past, present, and future of computational photography.

OpenAI’s Codex has already shipped hundreds of thousands of pull requests in its first month. But what is it really, and how will coding agents change the future of software?

How do you build real-time, expressive AI video from first principles? Hedra CEO Michael Lingelbach joins a16z to discuss model architecture, UX tradeoffs, and why character-centric design unlocks the next wave of generative media.

Fal co-ounder and CEO Burkay Gur and head of engineering Batuhan Taskaya join a16z general partner Jennifer Li to discuss how they built a generative AI inference platform that's optimized for speed, performance, and user experience.

a16z partner Joel de la Garza sits down with Socket founder and CEO Feross Aboukhadijeh to dive into the intersection of vibe coding and security.

a16z GP Martin Casado sits down with Metronome CEO Scott Woody to unpack how AI is fundamentally changing the value proposition of software—and why that shift demands a rethink of the traditional SaaS business model

a16z General Partner Jennifer Li discusses how AI is reshaping every layer of the software stack, creating demand for new types of middleware.

Labelbox CEO Manu Sharma explores the evolution of data labeling and evaluation in AI — from early supervised learning to today’s sophisticated reinforcement learning loops.

dbt Labs co-founder and CEO Tristan Handy sits down with a16z's Jennifer Li and Matt Bornstein to explore the next chapter of data engineering — from the rise (and plateau) of the modern data stack to the growing role of AI in analytics and data engineering.

Arcjet CEO David Mytton on the increasing complexity of managing who — including bots, crawlers, and AI agents — can access websites, and other web apps, and what they can do there.

Instabase founder and CEO Anant Bhardwaj discusses the revolutionary impact of LLMs on analyzing unstructured data and documents, and shares his vision for how AI agents could take things even further.

LMArena cofounders Anastasios N. Angelopoulos, Wei-Lin Chiang, and Ion Stoica sit down with a16z general partner Anjney Midha to talk about the future of AI evaluation.

Distributional CEO Scott Clark discusses why it's critical to continuously test generative AI systems to ensure expected behavior. In inherently chaotic systems, small upstream changes can have big downstream effects.

a16z Infra partners Guido Appenzeller, Matt Bornstein, and Yoko Li explore how generative AI is reshaping software development — from its potential as a new high-level programming abstraction to its current practical impacts.

Anthropic's David Soria Parra — who created MCP (Model Context Protocol) along with Justin Spahr-Summers — sits down with a16z's Yoko Li to discuss the project's inception, exciting use cases for connecting LLMs to external sources, and what's coming next for the project.