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Y Combinator Startup Podcast
Y Combinator
260 episodes
1 day ago
We help founders make something people want.
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Technology
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We help founders make something people want.
Show more...
Technology
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John Jumper: AlphaFold and the Future of Science
Y Combinator Startup Podcast
27 minutes 12 seconds
3 days ago
John Jumper: AlphaFold and the Future of Science

John Jumper on June 16, 2025 at AI Startup School in San Francisco.


John Jumper is a physicist-turned-computational biologist who led DeepMind’s AlphaFold team—and earned the 2024 Nobel Prize in Chemistry for solving protein folding, a decades-old scientific challenge.


In this talk, he shares how a deep learning breakthrough at CASP14 turned into AlphaFold 1 and then AlphaFold 2, delivering atomic accuracy predictions and revolutionizing biology. He explains the scientific puzzle behind protein folding, the key algorithmic breakthroughs, and the impact of making millions of protein structures accessible to researchers worldwide.

Y Combinator Startup Podcast
We help founders make something people want.