In this enlightening episode, we explore the essential building blocks of health optimization with our guest, Jason, a professor of neuroscience with whom we share both a past of academic rigor and a present of mutual interest in longevity maximizing our physical well-being. We start by emphasizing the crucial importance of genetics and getting the basics right—adequate sleep, proper nutrition, regular exercise, and minimizing exposure to toxins, to safeguard our own cells from damage—before even considering supplements as a way to enhance health and fight aging and cancer. Jason then shares insights from his fascinating journey, from obtaining his PhD to establishing his own lab, where he focuses on understanding subcellular organ quality control. This episode is a treasure trove of information for anyone interested in the science of health optimization, from the cellular level to holistic practices.