The hosts talk in detail about Epic Games' MetaHuman system, a toolset for creating and animating realistic digital humans within Unreal Engine 5. They explain how to use MetaHuman Creator to build custom characters, how to import and export them, and how to animate them using various techniques, including audio-driven animation. The hosts demonstrate the process of animating MetaHumans with audio files, bypassing the need for traditional motion capture. The overall focus is on streamlining the workflow for creating and implementing high-quality digital humans in game development and other projects.