In this episode, two veterinarians, Dr. Natalie Keith and Dr. Josiah Dame discuss lymphoma in dogs (and briefly in cats): common breeds and ages affected, how enlarged lymph nodes present, and the tests used to diagnose (aspiration cytology and PARR). They explain treatment options ranging from steroids and oral drugs to the CHOP chemotherapy protocol, address prognosis differences between B-cell and T-cell lymphoma, and share real clinical stories about rapid progression and difficult decisions. The episode also touches on feline GI lymphoma, the role of routine lab work, and how veterinarians balance diagnostics, treatment costs, and pet quality of life.