In this episode of VaxTalk, we dive into the latest on mpox, previously known as monkeypox. Dr. Kritika Kuppali from the University of Texas Southwestern joins us to explain what mpox is, how it's related to smallpox, and why it's become a global public health concern. While smallpox was eradicated in 1980, mpox has been on the rise, particularly in Central and West Africa. Dr. Kuppali discusses the reasons for this increase, including decreased immunity from the end of smallpox vaccinations and environmental changes that may affect its spread. We also explore the complex challenges of controlling mpox, from improving testing in regions with fragile healthcare systems to reducing stigma and ensuring supportive care. Dr. Kuppali talks about vaccines, such as JYNNEOS, used to protect high-risk populations and ongoing efforts to make these tools more accessible. Tune in to learn how global health experts and local communities work together to manage this outbreak and what role we all play in supporting these efforts.