Dr Garret FitzGerald, professor of Systems Pharmacology and Translational Therapeutics at the Perelman School of Medicine at the University of Pennsylvania joins me on the podcast today. Hailing from Wicklow, Garret is an international leader in cardiovascular disease research and leading world figure in pharmacology. He discusses his work into the development of low-dose aspirin for cardioprotection and his investigations into harmful effects and cardiovascular risks of NSAIDs. He also discusses the importance of the presence of molecular clocks in the cardiovascular system. We chat about his 'unusual' upbringing in the 'Grand Hotel' in Greystones, being an only child and the 'series of accidents' that have led to him becoming a physician scientist. We also discuss his move to London and subsequently the US and his hopes for the future of Irish science. Garret is also extremely passionate about bridging the gap between basic science and clinical impact and the importance of creating structures for career progression for younger researchers.    Follow Garret: FitzGerald__Lab Follow me: MeganHanlon4 This season is kindly sponsored by Bio-Sciences Ltd, now part of Thermo-Fisher Scientific.