I am so pleased to be joined by Dr Ellen Gravallese, Chief of the division of Rheumatology, Inflammation and Immunity at the Brigham and Women's Hospital, Harvard Medical School, this week. Ellen chats to me about her early days in pathology, how she ended up specializing in Rheumatology and her seminal research identifying osteoclasts as the cells that resorb bone in Rheumatoid Arthritis. She also chats to me about why she loves 'following a lead and solving a puzzle' and how she balances her many roles including her most recent role as 83rd President of the American College of Rheumatology. We also discuss how COVID has impacted medicine, the struggles of telemedicine and reformed clinical practice guidelines but also how rheumatologists should be 'in the room where it happens' as experts in immunology. What a better guest to have on National Arthritis Week - a total honour! Follow me: MeganHanlon4 This season is kindly sponsored by Bio-Sciences Ltd, now part of Thermo-Fisher Scientific.