Martin Picard and Thomas P Seager, PhD, delve into the intricate world of mitochondria, exploring their roles beyond energy production. They discuss how mitochondria influence human health, mental well-being, and even cancer dynamics. The dialogue also touches on the relationship between energy, information, and consciousness, proposing that our understanding of biology must evolve beyond the mechanical view of the body. The conversation culminates in a discussion about the epigenome and the potential for mitochondrial therapy to influence gene expression, suggesting a paradigm shift in how we approach health and healing.