Grief is often thought of as a psychological phenomenon. Yet loss also has a profound impact on our bodies, often affecting our cardiovascular, endocrine, and immune systems. As a Professor of Clinical Psychology and Psychiatry at the University of Arizona, Mary-Frances O’Connor specializes in studying the physiology of grief. In her new book, The Grieving Body: How the Stress of Loss Can Be an Opportunity for Healing, she draws from her clinical research and her personal experience to explore the toll that loss takes on our bodies—and what this can teach us about care, compassion, and interdependence. In this episode of Life As It Is, Tricycle’s editor-in-chief, James Shaheen, and meditation teacher Sharon Salzberg sit down with O’Connor to discuss the phenomenon of dying of a broken heart, how grieving can be thought of as a form of learning, how meditation can change how we show up for others, and the challenges of rediscovering a sense of purpose in the wake of loss.