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Trenches in Transplant Surgery
Sabin Subedi
45 episodes
6 days ago
Step into the forefront of abdominal transplant surgery — where innovation meets ongoing complexity. Machine perfusion and normothermic regional perfusion (NRP) are reshaping organ preservation and donor utilization, with growing evidence that these technologies improve graft assessment and early outcomes. Yet reviews continue to highlight key challenges — ischemia–reperfusion injury, biliary complications in DCD grafts, and the logistical demands of perfusion platforms. Despite these hurdles, transplantation is shifting from an urgent, unpredictable field toward a planned, daytime specialty. The next horizon, underscored by recent expert reviews, is true organ banking — bringing us closer to on-demand, schedulable transplantation.
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Medicine
Health & Fitness
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All content for Trenches in Transplant Surgery is the property of Sabin Subedi and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
Step into the forefront of abdominal transplant surgery — where innovation meets ongoing complexity. Machine perfusion and normothermic regional perfusion (NRP) are reshaping organ preservation and donor utilization, with growing evidence that these technologies improve graft assessment and early outcomes. Yet reviews continue to highlight key challenges — ischemia–reperfusion injury, biliary complications in DCD grafts, and the logistical demands of perfusion platforms. Despite these hurdles, transplantation is shifting from an urgent, unpredictable field toward a planned, daytime specialty. The next horizon, underscored by recent expert reviews, is true organ banking — bringing us closer to on-demand, schedulable transplantation.
Show more...
Medicine
Health & Fitness
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Acute Alcoholic Hepatitis and Liver Transplantation
Trenches in Transplant Surgery
18 minutes 39 seconds
3 months ago
Acute Alcoholic Hepatitis and Liver Transplantation

Severe acute alcoholic hepatitis (AAH), characterized by high short-term mortality (exceeding 75% at 6 months) in patients failing corticosteroid therapy (Lille score >0.45), represents a paradigm shift in liver transplantation, moving from historical contraindication to a potentially life-saving intervention for highly selected candidates. Landmark studies, notably Mathurin et al. (2011), demonstrated dramatically improved survival (70-85% at 5 years) with early LT compared to medical management alone in rigorously selected steroid-nonresponsive patients experiencing their *first* episode of decompensation. Crucially, strict selection criteria waive the traditional 6-month sobriety rule but mandate a definitive AAH diagnosis, confirmed steroid non-response, absence of severe comorbidities, and, most importantly, an exhaustive multidisciplinary psychosocial evaluation assessing insight, commitment to abstinence, strong social support, and engagement in long-term addiction treatment. While outcomes are excellent and harmful alcohol relapse rates post-LT (10-20% at 5 years) are comparable to patients transplanted for alcohol-related cirrhosis after meeting sobriety rules, significant ethical controversies persist regarding organ allocation fairness and the ability to perfectly predict relapse, necessitating careful protocolized implementation by transplant centers.

Trenches in Transplant Surgery
Step into the forefront of abdominal transplant surgery — where innovation meets ongoing complexity. Machine perfusion and normothermic regional perfusion (NRP) are reshaping organ preservation and donor utilization, with growing evidence that these technologies improve graft assessment and early outcomes. Yet reviews continue to highlight key challenges — ischemia–reperfusion injury, biliary complications in DCD grafts, and the logistical demands of perfusion platforms. Despite these hurdles, transplantation is shifting from an urgent, unpredictable field toward a planned, daytime specialty. The next horizon, underscored by recent expert reviews, is true organ banking — bringing us closer to on-demand, schedulable transplantation.