#8 Marie Passet: Novel high-risk B-cell ALL

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Trainee Pearls

The EBMT Trainee Committee

16 episodes

2 days ago

Welcome to “Trainee Pearls”, a new initiative brought to you by the EBMT Trainee Committee to deliver the most important messages (“the pearls”) of high-profile research works in hematology and bone marrow transplant to our fellow trainees all over the world. The topics will span from classical hematology to more focused bone marrow transplant research. The selected research article will be discussed directly with young authors who have been involved with the published work.

Medicine

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All content for Trainee Pearls is the property of The EBMT Trainee Committee and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.

Medicine

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#8 Marie Passet: Novel high-risk B-cell ALL

Trainee Pearls

25 minutes 24 seconds

3 years ago

#8 Marie Passet: Novel high-risk B-cell ALL

Oncogenic alterations underlying B-cell acute lymphoblastic leukemia (B-ALL) in adults remain incompletely elucidated. To uncover novel oncogenic drivers, Marie and her team performed RNA-seq and whole-genome analyses in a large cohort of unresolved B-ALL. Marie and colleagues identified a novel subtype characterized by a distinct gene expression signature and the unique association of two genomic microdeletions. Article link: https://ashpublications.org/blood/article/doi/10.1182/blood.2021014723/484449/Concurrent-CDX2-cis-deregulation-and-UBTF-ATXN7L3