Activist Claire Dearing (Bryce Dallas Howard_ is still leading the Dinosaur Protection Group to break up illegal breeding operations. Claire's partner, Owen Grady (Chris Pratt), captures and relocates stray dinos before they're slaughtered by poachers. They live in a cabin in the Sierra Nevadas with 14-year-old experimental human clone Maisie Lockwood (Isabella Sermon), raised as their surrogate daughter in secret to protect her from exploitation. The velociraptor raised by Owen, Blue, lives in the nearby woods with her asexually created younger hatchling, dubbed Beta by Maisie. Maisie is unhappy in isolation and occasionally strays beyond her parents' border, ultimately getting captured by mercenaries, who also kidnap Beta.

Meanwhile, genetically modified locusts begin consuming and destroying farm crops in America's heartland and will soon be a global threat. Paleobotanist Ellie Sattler (Laura Dern) discovers that crops from Biosyn seeds remain unaffected, suspecting foul play to monopolize the world's food market. She consults former paleontologist colleague and romantic partner Alan Grant (Sam Neill) for help. They discover that the locusts have been genetically modified using Cretaceous period DNA. Their detective work finds them joining forces with Claire and Owen to infiltrate Biosyn, where Ian Malcolm (Jeff Goldblum) is currently employed, to expose the greedy corporation's plans to the world.