A conversation with Fadi Issa about his recent article on regulatory T cell therapy in kidney transplants. In this episode of To Immunity and Beyond, Paul Klenerman talks with surgeon and immunologist Fadi Issa about pioneering regulatory T-cell therapy in kidney transplantation. Fadi shares his journey from reconstructive surgery to immune tolerance research and discusses the groundbreaking, first-in-human ONE Trial of T reg therapy in kidney transplantation. The trial showed promising graft survival rates, and found B cell-enriched focal lymphocytic infiltrates in the T reg treated group. Paul and Fadi also explore how current work with spatial transcriptomics will enable further insights into this mechanism.
Full article: Oliver McCallion, Amy R. Cross, Matthew O. Brook, Conor Hennessy, Ricardo Ferreira, Dominik Trzupek, William R. Mulley, Sandeep Kumar, Maria Soares, Ian S. Roberts, Peter J. Friend, Giovanna Lombardi, Kathryn J. Wood, Paul N. Harden, Joanna Hester, Fadi Issa, Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants, Med, Volume 6, Issue 5, 2025, 100561, ISSN 2666-6340, https://doi.org/10.1016/j.medj.2024.11.014.
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A conversation with Fadi Issa about his recent article on regulatory T cell therapy in kidney transplants. In this episode of To Immunity and Beyond, Paul Klenerman talks with surgeon and immunologist Fadi Issa about pioneering regulatory T-cell therapy in kidney transplantation. Fadi shares his journey from reconstructive surgery to immune tolerance research and discusses the groundbreaking, first-in-human ONE Trial of T reg therapy in kidney transplantation. The trial showed promising graft survival rates, and found B cell-enriched focal lymphocytic infiltrates in the T reg treated group. Paul and Fadi also explore how current work with spatial transcriptomics will enable further insights into this mechanism.
Full article: Oliver McCallion, Amy R. Cross, Matthew O. Brook, Conor Hennessy, Ricardo Ferreira, Dominik Trzupek, William R. Mulley, Sandeep Kumar, Maria Soares, Ian S. Roberts, Peter J. Friend, Giovanna Lombardi, Kathryn J. Wood, Paul N. Harden, Joanna Hester, Fadi Issa, Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants, Med, Volume 6, Issue 5, 2025, 100561, ISSN 2666-6340, https://doi.org/10.1016/j.medj.2024.11.014.
Starvation and infection: The role of sickness-associated anorexia in metabolic adaptation during acute infection
To Immunity and Beyond
26 minutes
8 months ago
Starvation and infection: The role of sickness-associated anorexia in metabolic adaptation during acute infection
Dr. Barbara Kronsteiner-Dobramysl discusses a recent Metabolism article: ‘Starvation and infection: The role of sickness-associated anorexia in metabolic adaptation during acute infection’. This episode discusses the following article: Jindal, J, Hill, J, Harte, J, Dunachie, S, and Barbara Kronsteiner, B, Starvation and infection: The role of sickness-associated anorexia in metabolic adaptation during acute infection. Metabolism 161 (December 2024). https://doi.org/10.1016/j.metabol.2024.156035
Barbara would like to specifically thank Ms. Jessy Jindal for the initial idea for this review. As part of her medical studies at the University of Oxford she wrote an essay about starvation and infection which inspired this publication. This work matured over several years and was shaped by all the co-authors and valuable input from reviewers and the editor until it reached its final version that is published now. We hope it is of interest to many and sparks conversation and new ideas for studies in this area. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/
To Immunity and Beyond
A conversation with Fadi Issa about his recent article on regulatory T cell therapy in kidney transplants. In this episode of To Immunity and Beyond, Paul Klenerman talks with surgeon and immunologist Fadi Issa about pioneering regulatory T-cell therapy in kidney transplantation. Fadi shares his journey from reconstructive surgery to immune tolerance research and discusses the groundbreaking, first-in-human ONE Trial of T reg therapy in kidney transplantation. The trial showed promising graft survival rates, and found B cell-enriched focal lymphocytic infiltrates in the T reg treated group. Paul and Fadi also explore how current work with spatial transcriptomics will enable further insights into this mechanism.
Full article: Oliver McCallion, Amy R. Cross, Matthew O. Brook, Conor Hennessy, Ricardo Ferreira, Dominik Trzupek, William R. Mulley, Sandeep Kumar, Maria Soares, Ian S. Roberts, Peter J. Friend, Giovanna Lombardi, Kathryn J. Wood, Paul N. Harden, Joanna Hester, Fadi Issa, Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants, Med, Volume 6, Issue 5, 2025, 100561, ISSN 2666-6340, https://doi.org/10.1016/j.medj.2024.11.014.
