A conversation with Fadi Issa about his recent article on regulatory T cell therapy in kidney transplants. In this episode of To Immunity and Beyond, Paul Klenerman talks with surgeon and immunologist Fadi Issa about pioneering regulatory T-cell therapy in kidney transplantation. Fadi shares his journey from reconstructive surgery to immune tolerance research and discusses the groundbreaking, first-in-human ONE Trial of T reg therapy in kidney transplantation. The trial showed promising graft survival rates, and found B cell-enriched focal lymphocytic infiltrates in the T reg treated group. Paul and Fadi also explore how current work with spatial transcriptomics will enable further insights into this mechanism.
Full article: Oliver McCallion, Amy R. Cross, Matthew O. Brook, Conor Hennessy, Ricardo Ferreira, Dominik Trzupek, William R. Mulley, Sandeep Kumar, Maria Soares, Ian S. Roberts, Peter J. Friend, Giovanna Lombardi, Kathryn J. Wood, Paul N. Harden, Joanna Hester, Fadi Issa, Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants, Med, Volume 6, Issue 5, 2025, 100561, ISSN 2666-6340, https://doi.org/10.1016/j.medj.2024.11.014.
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A conversation with Fadi Issa about his recent article on regulatory T cell therapy in kidney transplants. In this episode of To Immunity and Beyond, Paul Klenerman talks with surgeon and immunologist Fadi Issa about pioneering regulatory T-cell therapy in kidney transplantation. Fadi shares his journey from reconstructive surgery to immune tolerance research and discusses the groundbreaking, first-in-human ONE Trial of T reg therapy in kidney transplantation. The trial showed promising graft survival rates, and found B cell-enriched focal lymphocytic infiltrates in the T reg treated group. Paul and Fadi also explore how current work with spatial transcriptomics will enable further insights into this mechanism.
Full article: Oliver McCallion, Amy R. Cross, Matthew O. Brook, Conor Hennessy, Ricardo Ferreira, Dominik Trzupek, William R. Mulley, Sandeep Kumar, Maria Soares, Ian S. Roberts, Peter J. Friend, Giovanna Lombardi, Kathryn J. Wood, Paul N. Harden, Joanna Hester, Fadi Issa, Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants, Med, Volume 6, Issue 5, 2025, 100561, ISSN 2666-6340, https://doi.org/10.1016/j.medj.2024.11.014.
Ebola virus persistence: implications for human-to-human transmission and new outbreaks
To Immunity and Beyond
22 minutes
1 month ago
Ebola virus persistence: implications for human-to-human transmission and new outbreaks
A conversation with Miles Carroll and Oliver Meek about their recent Ebola virus persistence review article. In this episode, Oliver Meek and Miles Carroll discuss their recent review on Ebola virus (EBOV) persistence, set against the broader context of the West African epidemic. They share insights into how viral reservoirs form in immune-privileged sites and the immunological signatures linked to resistance. The conversation explores the implications of these findings on sexual transmission of EBOV, therapeutic development and strategies to prevent viral persistence and recrudescence. They also consider how these mechanisms may inform approaches to other emerging infectious diseases.
Full article: Meek O, Fornace K, Carroll MW. Ebola virus persistence: implications for human-to-human transmission and new outbreaks. Explor Med. 2025;6:1001333. https://doi.org/10.37349/emed.2025.1001333
Further reading:
Züst R, et al. Presence and Persistence of Andes Virus RNA in Human Semen. Viruses. 2023 Nov 17;15(11):2266. https://doi.org/10.3390/v15112266
To Immunity and Beyond
A conversation with Fadi Issa about his recent article on regulatory T cell therapy in kidney transplants. In this episode of To Immunity and Beyond, Paul Klenerman talks with surgeon and immunologist Fadi Issa about pioneering regulatory T-cell therapy in kidney transplantation. Fadi shares his journey from reconstructive surgery to immune tolerance research and discusses the groundbreaking, first-in-human ONE Trial of T reg therapy in kidney transplantation. The trial showed promising graft survival rates, and found B cell-enriched focal lymphocytic infiltrates in the T reg treated group. Paul and Fadi also explore how current work with spatial transcriptomics will enable further insights into this mechanism.
Full article: Oliver McCallion, Amy R. Cross, Matthew O. Brook, Conor Hennessy, Ricardo Ferreira, Dominik Trzupek, William R. Mulley, Sandeep Kumar, Maria Soares, Ian S. Roberts, Peter J. Friend, Giovanna Lombardi, Kathryn J. Wood, Paul N. Harden, Joanna Hester, Fadi Issa, Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants, Med, Volume 6, Issue 5, 2025, 100561, ISSN 2666-6340, https://doi.org/10.1016/j.medj.2024.11.014.
