A conversation with Fadi Issa about his recent article on regulatory T cell therapy in kidney transplants. In this episode of To Immunity and Beyond, Paul Klenerman talks with surgeon and immunologist Fadi Issa about pioneering regulatory T-cell therapy in kidney transplantation. Fadi shares his journey from reconstructive surgery to immune tolerance research and discusses the groundbreaking, first-in-human ONE Trial of T reg therapy in kidney transplantation. The trial showed promising graft survival rates, and found B cell-enriched focal lymphocytic infiltrates in the T reg treated group. Paul and Fadi also explore how current work with spatial transcriptomics will enable further insights into this mechanism.
Full article: Oliver McCallion, Amy R. Cross, Matthew O. Brook, Conor Hennessy, Ricardo Ferreira, Dominik Trzupek, William R. Mulley, Sandeep Kumar, Maria Soares, Ian S. Roberts, Peter J. Friend, Giovanna Lombardi, Kathryn J. Wood, Paul N. Harden, Joanna Hester, Fadi Issa, Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants, Med, Volume 6, Issue 5, 2025, 100561, ISSN 2666-6340, https://doi.org/10.1016/j.medj.2024.11.014.
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A conversation with Fadi Issa about his recent article on regulatory T cell therapy in kidney transplants. In this episode of To Immunity and Beyond, Paul Klenerman talks with surgeon and immunologist Fadi Issa about pioneering regulatory T-cell therapy in kidney transplantation. Fadi shares his journey from reconstructive surgery to immune tolerance research and discusses the groundbreaking, first-in-human ONE Trial of T reg therapy in kidney transplantation. The trial showed promising graft survival rates, and found B cell-enriched focal lymphocytic infiltrates in the T reg treated group. Paul and Fadi also explore how current work with spatial transcriptomics will enable further insights into this mechanism.
Full article: Oliver McCallion, Amy R. Cross, Matthew O. Brook, Conor Hennessy, Ricardo Ferreira, Dominik Trzupek, William R. Mulley, Sandeep Kumar, Maria Soares, Ian S. Roberts, Peter J. Friend, Giovanna Lombardi, Kathryn J. Wood, Paul N. Harden, Joanna Hester, Fadi Issa, Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants, Med, Volume 6, Issue 5, 2025, 100561, ISSN 2666-6340, https://doi.org/10.1016/j.medj.2024.11.014.
CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade
To Immunity and Beyond
34 minutes
4 months ago
CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade
A conversation with Ben Fairfax about the recent article: CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade. This episode discusses Milotay, G., Little, M., Watson, R.A. et al. CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade. Nat Med (2025). https://doi.org/10.1038/s41591-025-03647-1. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/
To Immunity and Beyond
A conversation with Fadi Issa about his recent article on regulatory T cell therapy in kidney transplants. In this episode of To Immunity and Beyond, Paul Klenerman talks with surgeon and immunologist Fadi Issa about pioneering regulatory T-cell therapy in kidney transplantation. Fadi shares his journey from reconstructive surgery to immune tolerance research and discusses the groundbreaking, first-in-human ONE Trial of T reg therapy in kidney transplantation. The trial showed promising graft survival rates, and found B cell-enriched focal lymphocytic infiltrates in the T reg treated group. Paul and Fadi also explore how current work with spatial transcriptomics will enable further insights into this mechanism.
Full article: Oliver McCallion, Amy R. Cross, Matthew O. Brook, Conor Hennessy, Ricardo Ferreira, Dominik Trzupek, William R. Mulley, Sandeep Kumar, Maria Soares, Ian S. Roberts, Peter J. Friend, Giovanna Lombardi, Kathryn J. Wood, Paul N. Harden, Joanna Hester, Fadi Issa, Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants, Med, Volume 6, Issue 5, 2025, 100561, ISSN 2666-6340, https://doi.org/10.1016/j.medj.2024.11.014.
