In Part 1 of this 3-part series on "the emperor of all maladies", Mickey Urdea tracked cancer all the way from Australopithecus bones and Egyptian mummies up to the first days of modern day protein assays for the detection of cancer markers, especially focusing on the contributions of the global pioneer in such assays, the company Centocor. Now in Parts 2 and 3, Mickey Urdea gets to move on to the wide panoply of tests and technologies that exist today for the screening, diagnosis, staging, prognostication, therapy selection, monitoring, and recurrence of cancer, with Part 2 highlighting those technologies focused on the whole body and specific tissue samples, and Part 3 zeroing in on individual molecules and “the in-between”.