On Episode 18 of “Interesting Stories in the History of Diagnostics”, Mickey Urdea is reviewing breath-based diagnostics, or what is transpiring with transpiration! Exhaled breath holds many secrets beyond what you ate for breakfast, and analysis of the compounds in breath can help to diagnose SARS-CoV-2, gastrointestinal disorders, and even lung cancer (among many others). New instruments and technologies are emerging and succeeding in the post-pandemic landscape, so it's not a waste of breath to say that breath-based diagnostics are the new frontier in non-invasive sample collection! Don't hold your breath, just tune in, for "Don't Hold Your Breath"!