In this podcast we discuss the role of the primary care physician in the initial diagnosis and work-up of patients suspected of having multiple sclerosis (MS). Specifically, we outline the approach to the diagnosis of MS and outline features that are common at the onset of MS as well as identify features that are atypical and would lead to a search for an alternate diagnosis. Our guest for this podcast is Dr. Michael Yeung, a clinical associate professor of Neurology at the University of Calgary and also an expert in MS. Dr. Yeung has been the director of the MS Clinical Trials Research program since 2007, and the Program Director of the adult neurology residency program at the University of Calgary since 2012. His disclosures will be published here shortly.The main reference used for this podcast is an article that Dr. Yeung and I recently co-authored:Brust, Tyson B and Yeung, Michael MC. When to suspect multiple sclerosis: common presentations and differential diagnosis. The Canadian Journal of Diagnosis; June 2014; 31(6).