In this episode of the Underdog Physician Podcast, Dr. Joshua Liu, co-founder and CEO of SeamlessMD, shares his journey from medical school to building a leading digital health platform that serves as a “GPS for patient care.” Inspired by an innovation lab during med school, Dr. Liu partnered with engineers in an incubator to develop SeamlessMD, which helps patients navigate complex health journeys while reducing readmissions, mortality, and healthcare costs. He discusses building a mission-driven team with strong clinical DNA, the challenges of integrating with major EHRs like Epic and Cerner, and the importance of mentorship, adaptability, and resilience in entrepreneurship. Dr. Liu also reflects on the evolving landscape of digital health, his decision to forgo residency, and the critical role of supportive mentors and family in his path.