Heart disease is still the top killer globally—but prevention and innovation are reshaping how we think about risk. In this episode of The Ty Beal Show, cardiologist Dr. Ethan Weiss—Chief Scientific Officer at Marea Therapeutics and long-time UCSF faculty expert—walks us through the intersection of genetics, metabolism, and cardiovascular health. Dr. Weiss explains the concept of cardio-endocrine medicine, where heart disease and metabolic disorders like diabetes are deeply interlinked, and explores how imaging, biomarkers, and genomics are improving risk prediction. We dive into LDL vs ApoB, the role of new lipid therapies, and how personalized prevention looks in practice. Along the way, Dr. Weiss shares his experience with a Mediterranean-style low-carb diet and his take on time-restricted eating. Takeaways from the episode include: Why metabolic disease is inseparable from cardiovascular risk How new tools (imaging, biomarkers, genetics) sharpen our prediction Evidence-based lifestyle and clinical strategies to reduce risk Evaluating low-carb diets, saturated fat, and fasting approaches What the future holds in therapies for lipoprotein(a) and beyond Find Dr. Ethan Weiss at Marea Therapeutics and UCSF. Connect with him on X. Connect with Ty on X, LinkedIn, Instagram, and Facebook. Sign up for Ty's Newsletter.