The purpose of this study was to understand what health related activities of residents living in transitional housing for the homeless increases their self-determination in managing their own health, what barriers exist, and what could nursing students do to increase their self-determination in managing their health. Methods: A qualitative approach using interviews, PhotoVoice, and observations was used. Twelve semi-structured interviews utilizing Critical Incident Technique, photos submitted by eight participants, and observation notes were used to learn more about the self-care health practices of people experiencing homelessness. Results: The themes that emerged from the interviews and PhotoVoice supported the Theory of Self-Determination, which states that in order for a person to be motivated to self-care, autonomy, competence, and relatedness must occur. Conclusions: Understanding the needs of the homeless is key to improving nursing care for this vulnerable population. This study fills the gap of understanding what health related activities of residents living in transitional housing for the homeless increases their self-determination in managing their own health, what barriers exist, and what nurses can do to increase their self-determination in managing their health.