In this special edition of the St Emlyn’s podcast, Iain Beardsell and Simon Carley review the top medical papers of 2024, originating from Simon’s talk at The Big Sick conference in Zermatt. The discussion includes a comparison of non-invasive versus arterial pressure monitoring, the association of intra-arrest arterial blood pressure with ROSC, the efficacy of serratus anterior plane blocks for rib fracture management, and the evaluation of a micro axial flow pump in cardiogenic shock. They also delve into double sequential external defibrillation in refractory out-of-hospital cardiac arrest and provide a rapid-fire review of additional critical papers discussed at the conference. Notable mentions include the HEMOTION trial, PRE OXI trial, BLING III, and PARAMEDIC-3, among others. A must-listen for those passionate about evidence-based medicine in emergency and pre-hospital care. You can read more about all the trials, including links to all the papers here (part 1) and here (part 2) 00:00 Introduction and Conference Highlights 01:51 Non-Invasive vs. Arterial Pressure Monitoring 03:28 Intra-Arrest Blood Pressure and ROSC 05:34 Serratus Anterior Plane Blocks for Rib Fractures 08:38 Micro Axial Flow Pump in Cardiogenic Shock 10:49 Double Sequential Defibrillation in Cardiac Arrest 13:17 HEMOTION Trial 15:01 PRE OXI and BLING III Trials 17:08 Fluid Management in Septic Shock 18:37 Expedited Transfer vs. On-Scene Resuscitation 20:39 Intraosseous vs. Intravenous Access 21:48 Conclusion and Final Thoughts