This episode takes a deep dive into Ghana’s experience managing the escalating costs of the National Health Insurance Scheme, while creating incentives for quality and responsiveness to patients, through provider payment reform. Sister Eugenia Amporfu provides important insights into navigating provider resistance to payment reforms and the importance of political economy and stakeholder buy-in. Finally, Ms. Agnes Gatome-Munyua and Dr. Cheryl Cashin discuss global lessons that listeners can draw from this experience.