Persistent Changes to Hunger Neurons May Lead to Weight Regain

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The People's Scientist

Dr. Stephanie Caligiuri

158 episodes

1 month ago

The People's Scientist is a weekly podcast covering the latest scientific findings on Neuroscience, Physiology, and Nutrition. I, your host, Dr. Stephanie Caligiuri, hold a Bachelor and Master degree in Nutritional Science, a PhD in Physiology, and Fellowship in Behavioral Neuroscience. I am currently a Scientist (Research Fellow) at Mount Sinai Hospital in NYC. Every week, I will provide you scientific evidence on important topics pertaining to our brain, body, and nutrition. In the past I have covered intermittent fasting, CRISPR gene editing for cancer therapy, using our own neurobiology to create new habits and break old habits, nicotine and the risk for type 2 diabetes, apple cider vinegar, our diet and depression, bitter tastants as a way to modulate cravings, and far more. Become a part of The People's Scientist Army today by subscribing and becoming more knowledgeable every week.

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Mental Health

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Persistent Changes to Hunger Neurons May Lead to Weight Regain

The People's Scientist

24 minutes 16 seconds

2 years ago

Persistent Changes to Hunger Neurons May Lead to Weight Regain

In episode 148, I go through the details of two recent studies investigating the impact of fasting on hunger and craving circuits within the brain. After one bout of fasting, persistent amplification of excitatory activity was noted onto agouti-related protein neurons of the arcuate nucleus of the hypothalamus. I believe these studies provide an understanding as to why we may binge and re-gain weight after weight loss. Can we use this information to our advantage? Yes. I give some neuroscience based strategies to help us prevent weight re-gain. Tune in for details.

References:

Grzelka et al., 2023, Cell Metabolism 35, 1–16

Kerem et al., 2020, Physiological Reports 28(4).e14369.

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