In the first PD Exchange podcast episode of 2025, Dr. Nikhil Shah and Dr. Jeff Perl introduce a groundbreaking topic—the ELIXIR trial to evaluate Xylocore, an innovative glucose-sparing solution for peritoneal dialysis. They are joined by experts Dr. Arduino Arduini and Dr. Richard Corbett, who delve into the formulation, rationale, and design of Xylocore, detailing the incorporation of xylitol and carnitine to optimize dialysis outcomes while minimizing glucose exposure. The discussion covers the scientific, clinical, and logistical aspects of the ongoing phase three trial, implications for diabetic patients, and future research directions, emphasizing the potential cardiometabolic benefits and improved patient engagement in PD therapy. 00:00 Introduction to the PD Exchange Podcast 00:54 Meet the Experts: Dr. Arduino Arduini and Dr. Richard Corbett 03:01 The Genesis of Xylocore: A Revolutionary PD Solution 12:11 Clinical Trials and Research Insights 28:05 Patient Engagement and Future Research Directions 33:12 Conclusion and Final Thoughts PDI Original Article: Rationale and design of ELIXIR, a randomized, controlled trial to evaluate efficacy and safety of XyloCore, a glucose-sparing solution for peritoneal dialysis Mario Bonomini Simon Davies Werner Kleophas Mark Lambie Gianpaolo Reboldi Lorenzo Di Liberato Josè Carolino Divino-Filho Olof Heimburger Alberto Ortiz Johan Povlsen Massimo Iacobelli Tommaso Prosdocimi Arduino Arduini PDI Editorial : Will Xylocore® be the magic ELIXIR for peritoneal dialysis? Johann Morelle Carl M. Öberg