Shantanu Singh is one of the principal investigators at the celebrated Broad Institute of MIT and Harvard. His research is centered around finding “fingerprints” of genes, chemicals and diseases from microscopy images of cells. Which has tremendous applications for drug discovery and curing diseases. I hope you enjoy this episode!

Also check out some more links about his work below:

About the Lab:

- Carpenter-Singh Lab: https://carpenter-singh-lab.broadinstitute.org/

- MIT Technology Review article on Cell Painting / JUMP Consortium: https://www.technologyreview.com/2023/03/03/1069261/a-technique-called-cell-painting-could-speed-drug-discovery/

- Recent review of Cell Painting applications: https://rdcu.be/d2vHH

Resources:

- Cell Painting Gallery (open image datasets): https://www.nature.com/articles/s41592-024-02399-z

- OASIS Consortium (liver toxicity prediction and reducing animal testing): https://oasisconsortium.org/

Additional Reading:

- On our two-PI lab model: https://www.asbmb.org/asbmb-today/people/083122/high-affinity-binding