In this series, PathPod gathers pathologists and trainees Around The Scope to discuss their work in depth. Today, we hear about prostate pathology and how optimization of Gleason grading can improve prognostic information. Our hosts, Dr. Mike Arnold (@MArnold_PedPath) and Dr. Andrew Bellizzi (@IHC_guy) talk with Dr. Jesse McKenney, Dr. Jane Nguyen (@janenguyen44) and Dr. Sean Williamson (@Williamson_SR) of the Cleveland Clinic. Hear about how PSA screening changed the biopsies that pathologists see, and how the art and science of re-examining Gleason grading refined prognosis for patients with prostate cancer. Featured articles: Histologic Grading of Prostatic Adenocarcinoma Can Be Further Optimized Analysis of the Relative Prognostic Strength of Individual Architectural Patterns in 1275 Patients From the Canary Retrospective Cohort: https://pubmed.ncbi.nlm.nih.gov/27635949/ Correlation of large cribriform carcinoma and ”unfavorable histology” with other Gleason pattern 4 subtypes: A proof-of-principle study evaluating 485 radical prostatectomy specimens with proposal for the concept of ”borderline histology”: https://pubmed.ncbi.nlm.nih.gov/39644729/ Proposal for an optimised definition of adverse pathology (unfavourable histology) that predicts metastatic risk in prostatic adenocarcinoma independent of grade group and pathological stage: https://pubmed.ncbi.nlm.nih.gov/38828674/ Classification of prostatic adenocarcinoma as favourable/unfavourable histology has high interobserver agreement in prostate needle core biopsies: https://pubmed.ncbi.nlm.nih.gov/40762236/ Public domain music: Main Stem by US Army Blues