For the latest episode of the Next ReGeneration podcast in 2024 hosts Anina and Elena are joined by Leonardo Trombelli. He shares his unique perspective on how periodontal treatments and implant surgery have evolved throughout the years to become less invasive for patients. Trombelli looks back on the serendipity moment when he came up with the idea of the single flap approach, that can be used to properly access many periodontal defects. He elaborates on taking advantage of the periosteum in peri-implant regenerative procedures and shares insights on how he came up with the Sub-periosteal peri-implant augmented layer (SPAL) technique to finally highlight his most recent idea of the pedicle periosteal flap. The connective tissue of Trombelli’s career as a researcher and clinicians is his lifelong mission on making surgical procedures less complex and more accessible to clinicians of various skill levels, while at the same time reducing the invasiveness of the interventions for the patients.