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The Next Experiment
The Next Experiment
7 episodes
1 week ago
It's vital that we make progress in biology. Yet today, understanding complex living systems is hard. But does it have to be? We're Markus and Phil, a biologist and a statistician. We created this podcast for anyone who believes that there might be a better way. Together, we'll discuss the best experiments to cut through biological complexity. Join us to explore the shape of the next experiment.
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Life Sciences
Science
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It's vital that we make progress in biology. Yet today, understanding complex living systems is hard. But does it have to be? We're Markus and Phil, a biologist and a statistician. We created this podcast for anyone who believes that there might be a better way. Together, we'll discuss the best experiments to cut through biological complexity. Join us to explore the shape of the next experiment.
Show more...
Life Sciences
Science
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What the Past Teaches Us About Future Experiments
The Next Experiment
25 minutes 47 seconds
11 months ago
What the Past Teaches Us About Future Experiments

To explore what the future of multidimensional experiments might look like, we decided to look back.


In this episode, we explored how different multi-dimensional (aka Design of Experiments, or DOE) methods have come about to date. 


Then, we pondered how these different methods, together with tech and software innovations, have brought both opportunities to scale multidimensional experimentation, and exciting questions on the best way to go about it.


Conversation highlights

  • 00:00 - Introduction

  • 01:04 - The question mark around automation: what to do with 1000+ runs  

  • 10:15 - History of multidimensional (Design of Experiments / DOE) methods to date:

    • 10:58 - Era 1: Factorial designs came about, and benefited agriculture

    • 15:12 - Era 2: Response surface methods emerged in process industries

    • 18:17 - Era 3: Software packages helped design the “optimal” experiment  

    • 21:29 - “DOE 4.0”: Bayesian optimization, and the pros and cons for biology 

    The Next Experiment
    It's vital that we make progress in biology. Yet today, understanding complex living systems is hard. But does it have to be? We're Markus and Phil, a biologist and a statistician. We created this podcast for anyone who believes that there might be a better way. Together, we'll discuss the best experiments to cut through biological complexity. Join us to explore the shape of the next experiment.