While ANCA-associated vasculitis can be described, in short, as damage to small blood vessels, there is a whole raft of different manifestations and symptoms to unravel to get to a diagnosis. The skin may be involved, as may the heart, kidneys, lungs, sinuses, the eyes, ears and nervous system - with management strategies dictated by the extent and severity to which organs are involved. In part two of our episode on vasculitis Dr Tony Sammel and Dr Daman Langguth share their experiences and tips diagnosing and treating ANCA-associated vasculitis. Dr Daman Langguth is VMO at Wesley Hospital, Brisbane, Director of Immunology and Chair of Partners Sullivan Nicolaides Pathology and Treasurer of the Australian and New Zealand Vasculitis Society. Dr Tony Sammel is staff specialist in rheumatology at Prince of Wales Hospital in Randwick and Sydney Eye Hospitals, where he coordinates the rheumatology vasculitis service, he has teaching appointments at the University of NSW and is Director of the Australian and New Zealand Vasculitis Society.