Summary In this episode of The Learning Curve, host Irtaza Asar and Dr. Craig Brewster discuss the complexities of diagnostic uncertainty in medicine. They explore how clinicians can navigate situations where clear answers are not available, emphasizing the importance of teaching medical students and residents to embrace uncertainty without compromising their confidence or critical thinking skills. The conversation covers the cultural pressures in medical training, strategies for managing uncertainty, and the significance of creating a supportive learning environment for future healthcare providers.   Takeaways Diagnostic uncertainty is a natural part of patient care. It's important to model vulnerability and humility to learners. Creating a safe learning environment encourages open discussions about uncertainty. Shared decision making with patients enhances care and understanding. Utilizing dual process theory can aid in clinical decision making. Encouraging learners to trust their instincts can improve patient outcomes. Understanding the patient's context is crucial in decision making. Teaching learners to embrace uncertainty fosters resilience in clinical practice. Regular reflection on clinical decisions can enhance learning. Collaboration with specialists is key in managing complex cases.