June Sarpong serves as a director on the board of the Lunchbox Fund, a non-profit organisation that provides a daily meal to pupils of township schools in Soweto, South Africa. She is also an ambassador for the Prince's Trust, and campaigns for the Make Poverty History movement. In April 2005 she visited Ghana to make a film for Make Poverty History. She also hosted the major Make Poverty History event in London’s Trafalgar Square in summer 2005 on behalf of Nelson Mandela and Bob Geldof. On 7 July 2007 she presented at the UK leg of Live Earth at Wembley Stadium, London.

In August 2014, Sarpong was one of 200 public figures who were signatories to a letter to The Guardian opposing Scottish independence in the run-up to September's referendum on that issue.

In October 2015, she joined the board of the Britain Stronger in Europe campaign, lobbying for the United Kingdom to remain in the European Union.

In October 2019, June Sarpong was appointed as the BBC's first Director of Creative Diversity