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Pun Name: PDAC in a Pod

Podcast Description: Journey into the fascinating realm of advanced cancer research, where tiny technologies are making a big impact on understanding the complexities of the disease, especially pancreatic ductal adenocarcinoma (PDAC). Listen as we explore how scientists are building sophisticated "lab-on-a-chip" models that recreate the intricate environment surrounding tumors, known as the tumor microenvironment (TME). Discover how these innovative systems allow researchers to study the crucial cross-talk between cancer cells and their surrounding stroma, including cancer-associated fibroblasts (CAF), various immune cells like tumor-associated macrophages (TAM), and even the vasculature. Learn about the exciting potential of these models for preclinical drug discovery, enabling the dynamic administration of drugs and the investigation of immune cell infiltration and polarization, offering a glimpse into the future of more effective cancer therapies.

Deipenbrock, A. et al. Modelling of the multicellular tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) on a fit-for-purpose biochip for preclinical drug discovery. Lab Chip (2025).

https://doi.org/10.1039/d4lc01016g