Explore the intricate world within our lungs' alveoli and their crucial immune responses using "alveolus-on-chip" technology. This innovative model replicates the air-liquid interface and integrates key cellular components like human distal lung epithelial cells (H441), human umbilical vein endothelial cells (HUVECs), and primary monocyte-derived macrophages. This in vitro platform allows researchers to closely observe and analyze the complex interactions between pathogens and the host's immune system within the pulmonary environment. Discover how this cutting-edge tool is advancing our understanding of respiratory infections and facilitating the development of potential therapeutic interventions for pulmonary health.

Koceva, H., Amiratashani, M., Rennert, K. & Mosig, A. S. Immunocompetent Alveolus-on-Chip Model for Studying Alveolar Mucosal Immune Responses. J. Vis. Exp., (207), e66602 (2024)