Ever wonder how our lungs defend themselves against the onslaught of infections like pneumonia, a leading cause of hospitalizations worldwide? This podcast dives deep into the intricate battle that unfolds within our respiratory system, exploring the crucial role of surfactant protein-A (SP-A) as a first line of immune defense. We unravel how a common bacterium, Staphylococcus aureus, can cleverly reduce the levels of this vital protein, potentially through its own proteases, and how this might weaken our lung's defenses. Discover the fascinating interplay between viruses like influenza and bacteria, and how their co-infection can impact SP-A expression, potentially contributing to more severe lung infections. Join us as we explore the complex interactions between our cells and these microscopic invaders, shedding light on the delicate balance that keeps our lungs healthy, informed by cutting-edge research using advanced models that mimic the human lung.